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Cornell University 
Announcements 

Graduate School of 
Medical Sciences 
1984 • 1985 



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Cornell University 
Announcements 

Graduate School of 
Medical Sciences 
1984 • 1985 



Academic Calendar 1984-85 



1984 

Labor Day Holiday 

Registration for first trimester* and 

Fall semester**; orientation for 

new students 
First trimester and Fall semester begin 
First trimester ends 
Examinations for first trimester 

Thanksgiving recess 

Registration for second trimester* 

Instruction begins for second trimester 
Winter recess: Instruction suspended, 
5:00 p.m. 



Monday, September 3 

Tuesday and Wednesday, 

September 4 and 5 
Thursday, September 6 
Wednesday, November 14 
Thursday, November 15- 

Wednesday, November 21 
Thursday and Friday, 

November 22 and 23 
Wednesday, November 21, and 

Monday, November 26 
Monday, November 26 

Friday, December 14 



1985 

Winter recess: Instruction resumed, 

9:00 a.m. 
Last day for completing requirements 

for January degrees 
Conferral of January degrees 
Fall semester ends 
Spring semester begins 
Second trimester ends 
Washington's Birthday observed 
Examinations for second trimester 
Registration for third trimester 
Third trimester begins 
Spring recess: 

Instruction suspended, 5:00 p.m. 

Instruction resumed, 9:00 a.m. 
Fifth Annual Vincent duVigneaud 

Memorial Research Symposium 
Last day for completing requirements 

for May degrees 
Commencement Day; conferral of 

May degrees 
Third trimester and Spring semester end 
Memorial Day Holiday observed 
Examinations for third trimester 



Wednesday, January 2 

Wednesday, January 9 

Wednesday, January 23 

Friday, January 25 

Monday, January 28 

Friday, February 15 

Monday, February 18 

Tuesday, February 19-Friday, March 1 

Friday, March 1, and Monday, March 4 

Monday, March 4 

Friday, March 29 
Monday, April 8 

Tuesday, May 7 

Friday, May 17 

Wednesday, May 22 

Friday, May 24 

Monday, May 27 

Tuesday, May 28-Friday, May 31 



*for students enrolling in courses 
* *for students conducting research only, who are on leave of absence, or are in absentia 



IV 



Summer Term 1985 

Registration for summer research term Monday, June 3 

Summer research term begins Monday, June 3 
Last day for completing requirements 

for August degrees Monday, August 12 

Summer research term ends Friday, August 23 

Conferral of August degrees Monday, August 26 



Note: Courses are trimestral; degrees are granted at ends of the Fall and Spring semesters 
and of the summer term. The dates shown in the calendar are subject to change at any 
time by official action of Cornell University. 

In enacting this calendar, the Graduate School of Medical Sciences has scheduled classes 
on religious holidays. It is the intent of the school that students missing classes due to 
the observance of religious holidays be given ample opportunity to make up work. 



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Contents 



Calendar iv 



Graduate School of Medical Sciences 

Purpose 1 

History 1 

Facilities 2 

Organization 2 

Special Programs (M.D.-Ph.D., Ph.D.-M.D.) 4 



Faculty and Research Activities 

Medical College Division 9 

Sloan-Kettering Division 38 



Requirements and Course Offerings 

Admission 57 

Degree Requirements 59 

Tuition and Fees 64 

Financial Assistance 65 

Scholarships and Fellowships 66 

Awards and Prizes 66 

Student Health Services 67 

Residence Halls 68 

Special Programs (M.D.-Ph.D., Ph.D.-M.D.) 68 

Instruction at the Medical College Division 71 

Instruction at the Sloan Kettering Division 84 



Register 95 
Index 115 



The courses and curricula described in this Announcement, and the 
teaching personnel listed herein, are as of July 1, 1984 and are subject 
to change at any time by official action of Cornell University. 



Cornell Medical Center 




Cornell University 

Graduate School of Medical Sciences 



Purpose 

The Graduate School of Medical Sciences, a semi-autonomous component of 
the Graduate School of Cornell University, provides opportunities for advanced 
study and research training in specific areas of the biomedical sciences. Graduate 
programs leading to the degrees of Doctor of Philosophy are offered in bio- 
chemistry, biophysics, cell and developmental biology, developmental therapy, 
genetics, immunobiology, molecular biology, microbiology, neurobiology and 
behavior, pathology, pharmacology, physiology, and virology. Certain of these 
fields of study also offer programs leading to the degree of Master of Science. 
Collaborative programs with Cornell University Medical College lead to the 
combined degrees of Doctor of Philosophy and Doctor of Medicine. 

The faculty of the Graduate School of Medical Sciences recommends the 
award of advanced general degrees not only as the result of the fulfillment of 
certain formal academic requirements, but also as evidence of the development 
and possession of a critical and creative ability in science. Demonstration of this 
ability is embodied in a dissertation which the candidate presents to the faculty 
as an original research contribution in the chosen area of study. 

A close working relationship between student and faculty is essential to 
the program of the Cornell University Graduate School of Medical Sciences. 
Guidance for each student is provided by a Special Committee, a group of at 
least three faculty members selected by the student. This Special Committee is 
granted extraordinary independence in working with its student. Other than a 
broad framework of Graduate School of Medical Sciences requirements for 
residence, examinations, and a thesis, and additional requirements of the par- 
ticular field of study chosen by the student, the Special Committee is free to 
design an individualized program of study with its student. No overall course, 
credit-hour, or grade requirements are set by the Graduate School of Medical 
Sciences. A student is recommended for a degree whenever the Special Com- 
mittee judges the student qualified. 

History 

The opportunity for graduate study leading to advanced general degrees in the 
biomedical sciences was first offered at the Cornell University Medical College, 
in cooperation with the Graduate School of Cornell University, in 1912. In June 
of 1950, Cornell University, in association with the Sloan-Kettering Institute 
for Cancer Research, established additional opportunities for graduate study 



I 



by forming the Sloan-Kettering Division of the Medical College. The resulting 
expansion of both graduate faculty and research training opportunities on the 
New York City campus prompted the organization in January 1952 of the 
Graduate School of Medical Sciences, composed of two cooperative but separate 
divisions, known as the Medical College Division and the Sloan-Kettering 
Division. The Graduate School of Medical Sciences was given full responsibility 
for advanced general degrees granted for study in residence at the New York 
City campus of Cornell University. 

Facilities 

Despite the divisional structure of the Graduate School of Medical Sciences, the 
courses offered by the two Divisions are open to all students, as are the general 
facilities of the Divisions such as libraries, dining halls, and recreational resources. 

The Medical College Division. The buildings along York Avenue between 
68th and 70th Streets accommodate both Cornell University Medical College 
and the Medical College Division of the Graduate School of Medical Sciences. 
Facilities available to graduate students include the Samuel J. Wood Library 
with a collection of over 127,000 volumes and subscriptions to 1,970 current 
journals, lecture rooms, study laboratories, seminar rooms and libraries of the 
basic science departments. Extensive research facilities are provided for faculty 
and students. 

The Sloan-Kettering Division. Its facilities are located within the Sloan-Kettering 
Institute for Cancer Research, which consists of the Howard, Kettering, and 
Schwartz Laboratory buildings on East 68th Street. In addition, the Walker 
Laboratory is located in Rye, New York. Each provide lecture and seminar 
rooms, and together represent more than 100 laboratories, which are available 
for biomedical research training. The Lee Coombe Memorial Library with 
23,600 volumes of books and journals is located in the 68th Street complex. 

Organization 

The faculty of the Graduate School of Medical Sciences is composed of the 
faculties of the Medical College Division, consisting primarily of the profes- 
sional staff of the basic sciences departments of Cornell University Medical 
College, and of the Sloan-Kettering Division, consisting of those professional 
staff members of the Sloan-Kettering Institute for Cancer Research who hold 
faculty appointments. 

Within each of the Divisions are Fields (Medical College Division) and 
Units (Sloan Kettering Division) of graduate instruction which are formed by 



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the faculty members in the respective Divisions with similar research and teach- 
ing interests. These Fields and Units of the Graduate School of Medical Sciences 
represent areas of concentration in which advanced degrees are offered. 

Executive Committee 

The Executive Committee is both the administrative and judicial board of the 
Graduate School of Medical Sciences and its members have continuing respon- 
sibility for the academic affairs of the school. The Committee is composed of 
the Chairpersons of the basic science departments of the Medical College Divi- 
sion and of the Programs of the Sloan-Kettering Division, the Directors of the 
Interdisciplinary Fields, the Dean and Associate Dean, the Provost for Medical 
Affairs of Cornell University, the Director and Associate Director of the Sloan- 
Kettering Division, the Chairperson and Vice-Chairperson of the Faculty Advisory 
Committee (see below), and two non-voting, elected student representatives. 

The Executive Committee considers such matters involving the interests 
and policies of the Graduate School of Medical Sciences as are referred to it by 
the Faculty Advisory Committee, by individual members of the Faculty, or are 
generated upon its own initiative. The Committee approves the addition or 
deletion of fields of study, reviews the admission of students, approves student's 
major and minor fields, reviews the curriculum and requirements for degrees. 

The Executive Committee is chaired by the Dean, who is the academic 
administrative officer of the Graduate School of Medical Sciences and is also 
an Associate Dean of the Graduate School of Cornell University. The Secretary 
of the Executive Committee is the Associate Dean, who is also an Assistant 
Dean of the Graduate School of Cornell University. 

Faculty Advisory Committee 

The Faculty Advisory Committee is the primary body representing the views of 
the Faculty of the Graduate School of Medical Sciences. The Committee advises 
the Dean and the Executive Committee on the impact of educational and policy 
matters under their consideration and recommends changes in educational 
activities, procedures, and policy of the Graduate School of Medical Sciences. 

The Faculty Advisory Committee is composed of one elected faculty repre- 
sentative of each Field of the Medical College Division and of each Unit of the 
Sloan-Kettering Division, and one elected student representative from each 
Division. The Chairperson and Vice-Chairperson of the Committee are elected 
by its membership. Non-voting members are the Dean and Associate Dean, 
the Provost for Medical Affairs of Cornell University, and the Director and 
Associate Director of the Sloan-Kettering Division. 



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Special Programs 



Medical Scientist Training Programs (M.D.-Ph.D.) 

These programs are designed to expose a student to both medical and graduate 
disciplines duting a six-year course of study. The combination of skills in basic 
research and experience in a clinical setting will prepare graduates from this 
program to pursue investigative careers in the biomedical sciences or in clinical 
medicine. The student spends the first two years as a medical student studying 
the basic medical sciences and attending regular graduate seminars. The sum- 
mer months are spent in the laboratory learning experimental techniques and 
doing research. The third, fourth, and fifth years of the student's program are 
spent as a full-time graduate student and are devoted mainly to laboratory re- 
search and writing the thesis. The sixth yeat of the program is devoted to clini- 
cal clerkships. This six-year program represents the minimum time required to 
satisfy residence requirements of both the M.D. and Ph.D. degrees at Cornell 
University. Successful applicants to the program will become M.D.-Ph.D. 
Fellows and will receive a full tuition scholarship and a stipend covering living 
expenses for the six-year period. 

Separate Medical Scientist Training Programs are offered by the Medical 
College and Sloan-Kettering Divisions: 

M.D.-Ph.D. Program at the Medical College Division: Preclinical and clinical 
training are provided by the faculty of Cornell University Medical College, 
while graduate education in research is offered by the faculty of the Medical 
College Division of the Cornell University Graduate School of Medical Sciences. 

M.D-Ph.D. Program at the Sloan Kettering Division: This program is spon- 
sored collectively by the Sloan-Kettering Division, the Rockefeller University, 
and Cornell University Medical College. The program requirements include 
the research-based Sloan-Kettering Division Ph.D. curriculum, the Cornell 
University Medical College curriculum, and a number of tri-institutional special 
learning opportunities designed specifically for the Medical Scientist candidates. 

For application to these programs, see p. 68. 
Ph.D. -M.D. Program 

Students enrolled in the Graduate School of Medical Sciences may be eligible 
for admission into the Ph.D. -M.D. Program, jointly sponsored by the Medical 
College and the Graduate School of Medical Sciences. This program is designed 
for those graduate students who find that their teaching and research goals re- 
quire the acquisition of the M.D. degree in addition to the Ph.D. degree. The 
program is not designed as an alternate path for students who have the M.D. 



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degree as their primary goal, but who have not been accepted by a medical 
school. Those who know, at the time of application to Cornell, that they want 
to pursue a course of study leading to both degrees should apply to one of the 
M.D.-Ph.D. programs described above. 

See p. 69 for application and graduation requirements of the Ph.D.-M.D. 
program. 



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6 



Faculty and Research Activities 



7 



Medical College Division 



Field of Biochemistry 

Faculty 

John P. Blass 
Adele L. Boskey 
Esther M. Brcslow 
Arthur J. L. Cooper 
Gordon F. Fairclough 
Jerald D. Gass 
Helena Gilder 
Jack Goldstein 
Owen W. Griffith 
David Hajjar 
Rudy H. Haschemeyer 
Bernard L. Horecker 
Chun-Yen Lai 
Raymond E. Lockard 
Alton Meister 



Ursula Muller-Eberhard 
Abraham Novogrodsky 
Aaron S. Posner 
Julian R. Rachele 
Robert R. Riggio 
Albert L. Rubin 
Brij B. Saxena 
Edward T. Schubert 
Richard L. Soffer 
Kurt H. Stenzel 
Suresh S. Tate 
Sidney Udenfriend 
Daniel Wellner 
Kenneth R. Woods 
David Zakim 



Research Activities 

Members of the field of Biochemestry are engaged in research spanning a wide 
spectrum of scientific areas. Thus, the research in Dr. Meister 's laboratory is 
concerned with the study of enzymes, especially those involved in amino acid, 
peptide, and protein metabolism. It involves the isolation of enzymes, the 
determination of their structure and properties, and the use of techniques 
such as isolation of mRNA and cDNA. The research is basic in nature, but 
significant relationships between this research and human disease have been 
discovered and are also being explored. Current work involves the metabolism 
and function of glutathione, including the relationships of this tripeptide to 
transport, metabolism, radiation, and chemotherapy. 

Research in Dr. Haschemeyer s laboratory concentrates on the develop- 
ment of physical methods to study molecular structure and interactions, and 
on the application of such methods to ascertain structure-function relationships 
in selected systems. Current emphasis is directed toward computer modeling 
of biological flow methods and heterogeneous-phase reactions and on immuno- 
electron microscopy of human serum lipoproteins. 



9 



Dr. Breslow is concerned with understanding, in a quantitative sense, the 
forces that determine the specificity of protein-protein interactions. She has 
been studying the interactions of the pituitary peptide hormones, oxytocin 
and vasopressin, with their storage protein, neurophysin. These studies are 
directed towards elucidating the binding site regions of the hormones and of 
the protein and at quantitating the energies of different components of the in- 
teraction. A second research project concerns the mechanism by which proteins 
are degraded intracellularly during normal protein turnover. The aims of these 
studies are to understand the precise role of ubiquitin, a small protein known 
to be involved in this process, and to elucidate the mechanisms underlying the 
selection of proteins for degradation. 

Current interest in Dr. Tate's laboratory is focused on the isolation, char- 
acterization, and ultrastructural localization of enzymes responsible for the for- 
mation of modified N- and C-terminal residues of peptide hormones in the 
hypothalamus and the pituitary gland. Synthetic peptide substrates are being 
used to identify and isolate an enzyme from bovine pituitary glands which is 
responsible for the formation of the C-terminal amide group of several hor- 
mones. In another project, three brush-border enzymes are being used as model 
systems to gain an understanding of the processes involved in the assembly of 
the highly specialized microvillus membranes. The enzymes under study are 
7-glutamyl transpeptidase, a dipeptidase, and aminopeptidase M. Current 
work includes a study of structure-function relations in these enzymes, their 
biogenesis, post-translational processing and sorting, and achievement of their 
final intracellular location. 

Dr. Griffith's research involves the design, synthesis and utilization in vivo 
of enzyme-selective inhibitors and substrates. These compounds are used both 
to evaluate and to control the metabolite flux thiough various pathways in 
intact animals. Recent studies have focused on the manipulation of glutathione 
and cysteine metabolism. Enzyme-selective inhibitors were developed that 
allow both glutathione biosynthesis and utilization to be blocked; techniques 
allowing extracellular cystine formation to be controlled were also developed. 
The inhibitors were shown to be useful in treating animal trypanosomiasis, 
enhancing oxidative killing of tumor cells, and preventing the formation of 
leukotriene C. New inhibitors are now being developed to allow in vivo control 
of carnitine metabolism. Applications of these compounds include the investi- 
gation and therapy of inherited diseases of lipid metabolism and diabetes. 

Research in Dr. Wellners laboratory is concerned with the structure and 
function of enzymes involved in amino acid metabolism, such as L- amino acid 
oxidase and threonine deaminase. Amino acid analyses of urine and blood of 
patients with inherited and acquired defects in amino acid metabolism are car- 
ried out as part of an effort to improve the diagnosis and treatment of these 
diseases. 

Dr. Lockard's research is directed towards understanding cytoplasmic con- 



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trol of eukaryotic gene expression. He is investigating the role of messenger 
RNA conformation in translational control and mRNA turnover. He is also 
studying the primary structure of rabbit 18S ribosomal RNA and its topography 
within the 40S subunit. 

Dr. Cooper's laboratory is working in the area of a-keto acid biochemistry 
and pyridoxal phosphate enzymes. Another area of active research is the metab- 
olism of amino acids and ammonia in the brain. For this purpose, molecules 
labeled with short-lived radioisotopes are synthesized and their distribution in 
brain is analyzed by positron emission tomography. Cerebral energy metabo- 
lism, with particular emphasis on the malate-aspartate shuttle, and its disrup- 
tion in various disease states is also being investigated. 

Dr. Horecker is working on the isolation and characterization of peptides 
from the thymus gland and evaluation of their possible function as hormones 
that regulate cellular immunity. The cloning of the genes for thymosin (3 4 
and for prothymosin 7 is a major current objective. Another project concerns 
the role of intracellular proteinases in the regulation of cellular processes, in- 
cluding their function in the turnover of intracellular proteins and in the cyto- 
toxic effects of human lymphocytes. 

Dr. Stenzel and Dr. Novogrodsky are interested in determining the molec- 
ular mechanisms involved in lymphocyte activation induced by the mitogenic 
oxidizing agents, sodium periodate and galactose oxidase. They are studying 
structural and functional alterations in cells rendered stimulatory by the oxi- 
dizing mitogens. These investigations include an analysis of the membrane 
sites oxidized and the possible cross-linked structures formed. Attempts are 
made to determine the requirements for stimulatory activity by reconstruction 
of stimulatory structures using hybridization and fusion techniques. They are 
also investigating structural and functional alterations in cells responsing to 
aldehyde-modified stimulatory cells and cell fractions, and their requirements 
for soluble growth factors. 

Studies are currently in progress in Dr. Hajjar's, laboratory to investigate 
the interaction of endothelial cells which line blood vessels with the underlying 
smooth muscle cells in an attempt to define the role of the endothelium in the 
process of cholesterol accumulation during arteriosclerosis. In addition, the role 
of herpes viruses as an etiological agent in the pathogenesis of lipid accumula- 
tion and arteriosclerosis is under investigation by studying the virus' effects on 
intracellular cholesterol metabolism and lipoprotein binding and metabolism. 

The main objective of Dr. Soffer's research is to characterize the physical, 
chemical, and biochemical properties of angiotensin II receptor which has been 
purified to a nearly homogeneous state from rabbit hepatic membranes. 

Dr. Posner is studying bone mineral structure and properties with emphasis 
on the elucidation of the biochemical processes of tissue mineralization. Tech- 
niques such as x-ray diffraction, electron microscopy, and infrared absorption 
spectrophotometry are used in this project. The role in the mineralization pro- 



1 1 



cess of the organic constituents of bone, such as collagen and proteoglycans, is 
of prime interest. 

Dr. Boskey's research is concerned with elucidating the factors controlling 
physiologic and dystrophic calcification. Hydroxyapatite formation and growth 
is studied in solution, in collagen gels, and in animal tissues. Recent studies 
have concentrated on the mechanism of action of proteoglycans (a mineraliza- 
tion inhibitor) and acidic phospholipids (promoters of mineralization). Studies 
are also in progress on the role of vitamin D metabolites in bone lipid 
metabolism. 

Dr. Lai's research is concerned with the structure and function of cholera 
toxin. Work from his laboratory has shown that subunit Al of cholera toxin is 
fully responsible for the toxin's ability to stimulate adenylate cyclase in mam- 
malian cells. Isolated subunit Al was also shown to catalyze an efficient trans- 
fer of the ADP-ribose moiety from NAD to a membrane protein. In another 
project, evidence has been obtained for a two-domain structure of the 
angiotensin converting enzyme: the hydrophobic carboxy-terminal portion of 
the enzyme is anchored to the cell membrane and the amino-terminal half, 
with the active site, is exposed to the blood circulation. Structural analyses in- 
dicate that the lung and testis enzymes may be the products of two distinct 
genes, and experiments are in progress to explain the close similarities between 
the two enzymes. 

Dr. Muller-Eberhard is investigating the mechanisms of transport of iron 
protoporphyrin IX and its metabolic precursors by proteins in the blood stream 
as well as within hepatocytes. She is studying the exchange of porphyrins be- 
tween proteins purified from serum and from hepatocytes; developing methods 
which delineate the function of these proteins in the delivery of porphyrins to 
hepatocytes and their intracellular distribution; and assessing the interaction of 
these proteins with artificial and biological membranes to learn how they may 
facilitate ligand transport across cellular and intracellular barriers. 

Dr. Goldstein is studying the structure and function of erythrocyte sur- 
face antigens and is working on enzymatic methods for the removal of immuno- 
dominant sugars responsible for blood group A and B activity. 

Dr. B/ass' research concerns cell biologic-metabolic aspects of degenerative 
diseases of the nervous system and focuses on the role of the pyruvate dehydro- 
genase complex (PDHC). Among other findings, a decrease in apparently nor- 
mal PDHC antigen and activity was found in histologically normal areas of 
brain from patients with Alzheimer disease, and a structural abnormality in the 
E3 (LAD) component of PDHC in Leigh disease, which impairs the assembly 
of the complex. 



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Recent Publications 



Blass.J.P. (with Shcu, K.-F.R., and Lai, J.C.K.), Pyruvate dehydrogenase phosphate phos- 
phatase in brain: Activity, properties, and subcellular localization. J. Ncurochem. 
40:1366-1372, 1983. 

Blass.J.P. (with Sheu. K.-F.R., and Lai, J.C.K.), Properties and regional distribution of pyruvate 
dehydrogenase kinase in rat brain. J. Neurochem. 42:230-236, 1984. 

Boskey, A.L. (with Chen, C-C, and Rosenberg, L.C.), The inhibitory effect of cartilage proteo- 
glycans on hydroxyapatite growth. Calcif. Tissue Int. 36:285-290, 1984. 

Boskey, A.L, (with Timchak, D M.), Phospholipid changes in the bones of the vitamin D- 

deficient, phosphate-deficient, immature rat. Metab. Bone Dis. and Rel. Res. 5:81-85, 
1983. 

Breslow, E. (with Sardana, V.), Proton magnetic resonance and binding studies of proteolytically 
modified neurophysins. J. Biol. Chem. 259:3669-3679, 1984. 

Cooper, A.J.L. (with Fitzpatrick, S.M., Ginos, Z., Kaufman, C, and Dowd, P.), Inhibition of 
glutamate-aspartate transaminase bv ^-methylene-DL-aspartate. Biochem. Pharmacol. 
32:679-689. 1983. 

Cooper, A.J.L. (with Fitzpatrick. S.M., and Duffy, T.E.), Use of #-methylene-DL-aspartate to 
assess the role of aspartate aminotransferase in cerebral oxidative metobolism. J. Neuro- 
chem. 41:1370-1383, 1983. 

Goldstein, J. , Biochemical manipulation of blood groups. In: Clinics in Immunology and 

Allergy, van Rood, J.J. , de Vreis. R.R.P., eds., W.B. Saunders, London, Vol. 4, No. 3, 
in press. 

Goldstein, J. (with Kuo, K-Y.), or-D-galactosidase immobilized on a soluble polymer. Enzyme 
Microb. Technol. 5:285-290, 1983. 

Griffith, O.W., Cysteinesulfinate metabolism: Altered partitioning between transamination 
and decarboxylation following administration of tf-methylene-DL-aspartate. J. Biol. 
Chem. 258:1591-1598, 1983. 

Hajjar, D P. (with Weksler. B.B.), Metabolic activity of cholesteryl esters in aortic smooth muscle 
cells is altered by prostaglandins I 2 and E 2 . J. Lipid Res. 24:1176-1185, 1983. 

Hajjar, D P. (with Minick, C.R., and Fowler, S.D.), Arterial neutral cholesteryl esterase: A 

hormone-sensitive enzyme distinct from lysosomal esterase. J. Biol. Chem. 258:192-198, 
1983. 

Haschemeyer, R.H. (with Todd, G.P.), Generalized finite element solution to one-dimensional 
flux problems. Biophysical Chem. 17:321-336, 1983. 

Haschemeyer, R.H. (with Wall, J., Hainfeld.J., and Mossesson, M.W.), Analysis of human 
fibrinogen by scanning transmission electron microscopy. Annals N Y. Acad. Sci. 
408:164-179. 1983. 

Horecker, B.L. (with Pontremoli, S., Melloni, E., SaJamino, F., Sparatorc, B., and Michetti, M ), 
Cytosolic Ca J *-dependent neutral proteinases from rabbit liver: Activation of the proen- 
zymes by Ca 2 * and substrate. Proc. Natl. Acad. Sci. U.S.A. 81:53-56, 1984. 

Horecker, B.L. (with Wodnar-Filipowicz, A., Gubler, U., Furuichi, Y., Richardson, M., 

Nowoswiat, E.F., and Poonian, M.S.). Cloning and sequence analysis of cDNA for rat 
spleen thymosin B 4 . Proc. Natl. Acad. Sci. U.S.A. 81:2295-2297, 1984. 

Lai. C-Y. (with Xia, Q-C and Salotra. P.), Location and amino acid sequence around the 

ADP-ribosylation site in the cholera toxin subunit Ai. Biochem Biophys. Res. Commun 
116:341-348, 1983. 



13 



Lai, C-Y. (with Iwata, K., Blacher, R., and Soffer, R.L.), Rabbit pulmonary angiotensin- 

converting enzyme: The NH 2 -terminal fragment with enzymatic activity and its forma- 
tion from the native enzyme by NH4OH treatment. Arch. Biochem. Biophys. 
227:188-201, 1983. 

Meister, A. (with Anderson, M.E.), Glutathione. Ann. Rev. of Biochem. 52:711-760, 1983. 

Meister, A., Selective modification of glutathione metabolism. Science 220:471-477, 1983. 

Muller-Eberhard, U. (with Pasternack, R.F., Gibbs, E.F., Hoeflin, E., Kosar, W.P., Kubera, G., 
Skowroneck, C.A., and Wong, N.M.), Hemin binding to serum proteins and the 
catalysis of interprotein transfer. Biochemistry 22:1753-1758, 1983. 

Muller-Eberhard, U. (with Fooidart, M., Liem, H.H., Adornato, B.T., and Engel, W.K.), 
Hemopexin metabolism in patients with altered serum levels. J. Lab. Clin. Med. 

102:838-846, 1983. 

Posner, A.S. (with McGann, T.C.A., Kearney, R.D., Buchheim, W., Betts, F., and Blumenthal, 
N.C.), Amorphous calcium phosphate in casein micelles of bovine milk. Calcif. Tis. Int. 

35:821-823, 1983. 

Posner, A.S. (with Thompson, D.D., Laughlin, W.S., and Blumenthal, N.C.), Comparison of 
bone apatite in osteoporotic and normal eskimos. Calcif. Tis. Int. 35:392-393, 1983. 

Soffer, R.L. (with Sen, I., and Bull, H.G.), Isolation of an angiotensin Il-binding protein from 
liver. Proc. Natl. Acad. Sci. U.S.A. 81:1679-1683, 1984. 

Stenzel, K.H. (with Lipkowitz, S., Rubin, A.L., and Novogrodsky, A.), Cellular and growth 
factor requirements for activation of human T lymphocytes by neuraminidase and 
galactose oxidase-treated lymphoid cells. J. Immunol. 130:2702-2712, 1983. 

Stenzel, K.H. (with Lipkowitz, S., Greene, W.C., Rubin, A.L. and Novogrodsky, A.), Expres- 
sion of receptors for interleukin-2: Role in the commitment of T lymphocytes to prolifer- 
ate. J. Immunol. 132:31-41, 1984. 

Tate, S.S. (with Nash, B.), In Vitro translation and processing of rat kidney 7-glutamyl trans- 
peptidase. J. Biol. Chem. 259:678-685, 1984. 

Tate, S.S. (with Husain, I.), Formation of the COOH-terminal amide group of thyrotropin- 
releasing factor. FEBS Lett. 152:277-281, 1983. 

Wellner, D. (with Stoner, E., Starkman, H., Wellner, V.P., Sassa, S., Rifkind, A.B., Grenier, A., 
Steinherz, P.G., Meister, A., New, M.I., and Levine, L.S.), Biochemical studies of a 
patient with hereditary hepatorenal tyrosinemia: Evidence of glutathione deficiency. 
Pediatr. Res., in press. 



Field of Cell Biology and Genetics 
Faculty 



Fred H. Allen 



C. Richard Minick 
Ralph L. Nachman 
Joel D. Pardee 



Vincent G. Allfrey 
Rosemary F. Bachvarova 
David M. Bader 



David M. Phillips 



14 



Arthur Bank 


Enrique M. Rabellino 


Carl G. Becker 


Michael Risley 


J. Michael Bedford 


Toby C. Rodman 


T"\ _ 1 T~) 

Dorothea Bennett 


Enrique Rodriguez-Boulan 


Calso Bianco 


n LI T) L 

Pablo Rubenstein 


Adcle L. boskey 


iNurul H. Sarkar 


Dana C. Brooks 


Brij B. Saxena 


\Y/ TaA Rmn.n 

w . led Drown 


Edward T. Schubert 


Peter U. bullough 


Joan Rankin Shapiro 


Kaju S. Chaganti 


C 1 C II ' 

Selma Silagi 


Moses Chao 


Marcello Siniscalco 


r> ci_ T\ 

B. Shannon Danes 


T 1 ' T C* ' 1 ' 

Julio L. Sirhn 


Donald A. Fischman 


Gregory W. Siskind 


James L. German III 


Richard Sterner 


raknry U. Lrirgis 


Koy L. Swan 


Jack Goldstein 


Paula iraktman 


Lloyd H. Urar 


Steven S. Wacntel 


Hans-Peter Hoffman 


uons a. wan 


Barbara H. Hosein 


Babette B. Weksler 


Edward M.Johnson 


David Zakim 



Research Activities 

Research is conducted in virtually all major fields of cell biology and genetics 
with a broad range of methodologies and facilities available. Opportunities 
are often available for interested students to extend basic research to a clinical 
setting. 

Research in basic cell biology includes the analysis of muscle, both skeletal 
and cardiac, with respect to control of gene expression, development, and the 
organization of proteins into myofibrils. In addition, mechanisms of cell 
motility, including control of assembly of actin filaments, are being studied 
in the simple organism Dictyostelium . Other research programs include studies 
of the mechanism of receptor mediated endocytosis using as an example the 
uptake of yolk by amphibian oocytes, and analysis of epithelial cell polarity, 
in particular the mechanism by which viruses are vectorially directed within 
the cell. Most of the above projects use a variety of methods including bio- 
chemical, immunochemical, recombinant DNA, cytological, and ultra- 
structural approaches to the problem. 

Recombinant DNA techniques are particularly emphasized in projects 
involving the analysis of cell surface receptors, the mechanism of immuno- 
globulin heavy chain switching, replication of DNA in vaccinia virus as an 
example reflecting eukaryoric cell mechanisms, evolution of the multigene 



15 



immunoglobulin family, and regulation of gene expression and tumorigenicity 
in melanoma and neuroblastoma cell lines. 

Cytogenetics and somatic cell genetics are important parts of the program 
in Genetics. Both techniques are being used in the analysis of inherited diseases 
which predispose to cancer, as well as the expression of mutant genes in cultured 
cell lines carrying these diseases. Cytogenetic approaches to visualize the effects 
of toxic agents and chemotherapeutic agents on the chromosomes of male 
germ cells are being developed. Somatic cell genetics as well as recombinant 
DNA techniques are being used to map the human genome, particularly the 
X chromosome. 

Studies of mammalian development include an effort to understand the 
nature of mutations which affect embryonic development of the mouse using 
both classical genetics and recombinant DNA techniques. Storage of RNA 
transcripts in mouse oocytes and their fate during meiotic maturation and early 
development are being followed. 

Reproductive biology is represented by studies of the physiology of the 
reproductive tract, studies of spermatozoa using functional and ultrastructural 
approaches, organization of chromatin in spermatozoa and oocytes, in vitro 
studies of cell interactions during spermatogenesis, and comparative repro- 
ductive biology. 

Other areas represented in the field include immunology, transplantation 
and immunogenetics, structure and function of monocytes and platelets, 
analysis of the basis of cardiovascular disease, and gene amplificaiton as a 
mechanism of drug resistance in human tumor cells. 

Recent Publications 

Allen, F.H., Jr. (with Mayr, W.R., and Lee, C.L.), RMNE (Random Men not Excluded) calcula- 
tions fot two-locus system such as HLA. Chapter 24. In: Inclusion Probabilities in Par- 
entage Testing. R.H. Walker, ed. American Association of Blood Banks, pp. 297-304, 
1983. 

Allen, F.H., Jr., Paternity case analysis. Chapter 34 in Inclusion Probabilities in Parentage 
Testing. R.H. Walker, ed., pp. 489-490, 1983. 

Allfrey, V.G. (with Sterner, R., and Sun, I.Y.-C) Affinity probes for protein acetylation and 
phosphorylation. In: Post-translational Covalent Modificaiton of Proteins for Function. 
Conner Johnson, B., ed., Academic Press, N.Y., pp. 181-203, 1983. 

Allfrey, V.G. (with DiPaola, E., and Sterner, R.), Protein side-chain acetylations. In: Post- 
translational Modifications. Moldave, K. and Wold, F., eds., Methods in Enzymology 
Vol. 107, Academic Press, N.Y. 1983 

Bachvarova, R. (with DeLeon, V., and Johnson, A.), Half-lives and relative amounts of stored 
and polysomal ribosomes and poly (A) + RNA in mouse oocytes. Devel. Biol. 98: 
400-408, 1983. 



16 



Bachvarova, R. (with Moy, K ), Autoradiographic studies on the distribution of labeled maternal 
RNA in early mouse embryos. J. Exp. Zool. In press. 

Bader, D. (with Gonzalez- Sanchez, A.) Immunochemical analysis of myosin heavy chains in 
the developing chicken heart. Develop. Biol. 103:151-158, 1983. 

Bank. A.. The world of new genetics. In: Human Molecular Genetics. Ramirez, F., cd., Marcel 
Dekker. 1984. 

Bank, A (with Mears, J.G.), The genetic defects in the thalassemias. In: Current Topics in 
Hematology, Piomclli, S., ed. Alan R. Liss, ed., 1984. 

Becker, C.G. (with Minick, C.R.), Environment risk factors and vasculature disease. In: Environ- 
mentally Induced Chronic Health Effects, edited by Woodhead, A D. and Water, M., 
eds. U.S.A. Environmental Protection Agency. EPA, 600:136-174, 1983. 

Becker, C.G. (with Francus, T., and Siskind, G.W.), The role of antigen structure in regulation 
of IgE isotypc expression. Proc. Natl. Acad. Sci. 80:3430-3444, 1983. 

Bedford. J. M. (with Witkin, S.S.), Influence of complement depletion on sperm function in 
the female rabbit J Reproduct. Fertil. 69:523-528, 1983. 

Bedford, J. M. (with Rodger, J. C. and Breed, W.G.). Why so many mammalian spermatozoa — 
a clue from marsupials. Proc. Roy. Soc. B. 221:221-233, 1984. 

Bennett, D. (with Shin, H-S., McCormick, P., and Artzt, K.), Cis-trans test shows a functional 
relationship between non-allelic lethal mutations in the T/t-complex. Cell 3:925-929, 
1983. 

Bennett, D. (with Shin, H-S., Flaherty, L., Artzt, K., and Ravetch, J.), Inversion in the H2 
complex of t-haplotypes in mice. Nature 306:380-383, 1983. 

Bianco, C, Fibrin, fibronectin and macrophages. In: Molecular Biology of Fibrinogen and 

Fibrin, M.W. Mosesson & R.F. Doolittle, eds. Ann. NY Acad. Sci. 408:602-609, 1983. 

Bianco, C. (with Godfrey, H P., Channabasappa, V.A., and Wolstencroff, R.A.), Localization 
of macrophage (agglutination factor activity) to the gelatin binding domain of fibro- 
nectin. J. Immunol. 133:1417-1423, 1984. 

Boskey, A.L. (with Timchak, D M., and Vigorita, V.), Lipid involvement in non-osseous tissue 
repair. Proc. Soc. Exp. Biol. Med. 174:59-64, 1983. 

Boskey, A.L. (with Timchak, D M ), Phospholipid changes in the bones of the Vitamin D 
deficient, phosphate deficient, immature rats. Metabolic Bone Dis. & Related Res. 
5:81-84, 1984. 

Brown. W.T. (with Wisniewski. H.M.), Genetics of human aging. Rev. of Bio. Res. in Aging 
1:81-99, 1983. 

Brown. W.T. (with Devine, E.A., Nolin, S.L., Houck, G.E. , Jenkins, EC, and Miller, D.L.), 
Isolation and regional localization by in situ hybridization of a unique gene segment to 
chromosome 21. Biochem. & Biophys. Res. Comm. 121:380-385, 1984. 

Bullough. P.G. (with Vigorita, V.J.), In: An Atlas of Orthopaedic Pathology Gower Medical 
Publ.. Ltd.. London, 1984. Univ. Park Press. Baltimore. Md.. 1984. 

Bullough. P.G. (with Boskey, A.L., and Lewinson, D ), The effects of trifluoroperazine on 

calcifying tissues in the immature rat Proc. Soc. Exp. Bio. & Med. 176:154-163. 1984. 

Chaganti, R.S.K., Significance of chromosome change to hematopoietic neoplasms. Blood 
62:515-525, 1983. 

Chaganti R.S.K. (with Schneider, N R., Chaganti, SR., and German, J ), Familial predisposition 
to cancer and age at onset of disease in randomly selected cancer patients. Am. J. Hum 
Genet. 35:454-467, 1983. 



L7 



Chao, M.V. (with Mellon, P., Charney, P., Maniatis, T., and Axel, R.), The regulated 

expression of globin genes in mouse erythroleukemia cells. Cell 32:483-493, 1983. 

Chao, M.V. (with Mellon, P., Wold, B., Maniatis, T., and Axel, R.), Regulation of globin 

genes introduced into murine erythroleukemic cells. In: Cell Fusion: Gene Transfer and 
Transformation, Vol. 14, Beers, R. and Bassett, W., eds. Raven Press, N.Y. pp. 89-100, 
1984. 

Danes, B.S. (with Lynch, H.T.), Increased in vitro tetraploidy in dermal monolayer cultures 
derived from normals. Cancer Genet. Cytogenet. 8:81-87, 1983. 

Danes, B.S., Heritable colon cancer syndromes: Long-term B-lymphocyte suspension cultures 
derived from colonic mucosal biopsies. Carlsberg Res. Commun. 49:187-195, 1984. 

Fischman, D.A. (with Danto, S.I.), Immunochemical analysis of intermediate filaments in 

embryonic heart cells with monoclonal antibodies to desmin. J. Cell Biol. 98:2179-2191, 
1984. 

Fischman, D.A. (with Dennis, J. E., Shimizu, T., and Reinach, F.C.), Localization of C-protein 
isoforms in chicken skeletal muscles: Ultrastructural detection using monoclonal anti- 
bodies. J. Cell Biol. 98: 1514-1522, 1984. 

German, J., editor, Chromosome Mutation and Neoplasia. Alan R. Liss, Inc., New York, 1983. 

German, J., The embryonic stress hypothesis of tcratogenesis. Am. J. Med. 76:293-301, 1984. 

Goldstein, J., Enzymatic conversion of red cell ABO groups for transfusion. In: Recent Advances 
in Haematology, Immunology and Blood Transfusion, S.R. Hollan et al., eds. Pub. 
Hungarian Acad. Sci. Budapest, pp. 89-97, 1983. 

Graf, L.H.,Jr. (with Kaplan, P., and Silagi, S.), Efficient DNA-mediated transfer of selectable 
genes and unselected sequences into differentiated and undifferentiated mouse melanoma 
cells. Som. Cell & Mol. Gen. 10:139-151, 1984. 

Hosein, B. (with Palmer, G.), The kinetics and mechanism of oxidation of reduced spinach 

ferredoxin by molecular oxygen and its reduced products. Biochimica et Biophysica Acta 

723:383-390, 1983. 

Johnson, E M. (with Bergold, P.J., Campbell, G.R., and Littau, V.C.), Sequence and hairpin 
structure of an inverted repeat series at termini of the Physarum extrachromosomal 
rDNA molecule. Cell 32:1287-1299, 1983. 

Johnson, E.M. (with Bergold, P.J., and Campbell, G.R.), Functional architecture at telomeres 
of the linear DNA in eukaryotes. In: Recombinant DNA and Cell Proliferation, Stein 
G., and Stein, J., eds. Acad. Press, NY., pp. 303-334, 1984. 

Minick, C.R. (with Falcone, D.J., and Hajjar, D.P.), Lipoprotein and albumin accumulation 
in rcendothelialized and deendothelialized aorta. Amer. J. Pathol. 114:112-120, 1984. 

Minick, C.R. (with Falcone, D.J. and Hajjar, D.P.), Correlation of morphological and bio- 
chemical components of atherosclerotic plaques. In: Clinical Diagnosis of Athersderosis. 
Quantitative Methods of Evaluation. Bond, M.G., Insull, S., Glagov, Chandler, B., and 
Cornhill, F., eds. Springer Verlag, New York and Heidlberg, Berlin, pp. 369-388, 1984. 

Nachman, R.L. (with Polley, M.J.), Human platelet activation by C3a and C3a des arg. J. Exp. 
Med. 158:683-615, 1983. 

Nachman, R.L. (with Leung, L.L.K., KJoczewiak, M., and Hawiger, J.), Complex formation of 
platelet membrane glycoprotein lib and Ilia with fibrinogen D domain. J. Biol. Chem. 
259:8584-8588, 1984. 

Phillips, D.M. (with Kalay, D.), Observation on mechanisms of flagellar motility deduced from 
backwards swimming bull sperm. J. Exp. Zool. 231:109-116, 1984. 



18 



Phillips, D M., Problems in the analysis of mammalian fertilization. In: Ultrastructure of 
Reproduction and Early Development, Van Berkom and Motta, eds. pp. 166, 1984. 

Rabellino, F.M. (with Levene, R.B., Nachman, R.L., and Leung, L.L.K.), Human megakaryocytes 
III. Characterization in myeloproliferative disorders. Blood 63:615-622, 1984. 

Rabellino, E., Biology of human mcgakaryotes: Recent developments. In: Progress in Hemostasis 
and Thrombosis. Spaet, T., cd., Grunc and Stratton, New York, 1984 (vol. 7). In press. 

Risley, M.S., Spermatogenic cell differentiation in vitro. Gamete Research 4:331-346, 1983. 

Rodman, T.C. (with Pruslin, F.H.), Proteins of demembraned protamme-deplctcd mouse 

sperm. Homology with proteins of somatic cell nuclear envelope /matrix. Exp. Cell Res. 
144:115-126, 1983. 

Rodman, T.C. (with Pruslin, F.H., Chiorazzi, N., Michelis, M.A. and Winston, R.), pl5, A 
nuclear-associated protein of human sperm. Identification of four variants and their 
occurrence in normal and abnormal seminal cells. Gamete Res. 8:129-147, 1983. 

Rodriguez-Boulan, E. (with Paskiet, K., and Sabatini, D.D.), Assembly of enveloped viruses in 
Madin-Darby canine kidney cells: Polarized budding from single attached cells and from 
clusters of cells in suspension. J. Cell Biol. 96:866-874, 1983- 

Rodriguez-Boulan, E., Polarized assembly of enveloped RNA viruses from cultured epithelial 
cells. In: Methods in Enzymology. Fleischer, S. and Fleischer, B., eds. Academic Press, 
New York, pp. 486-500, 1983. 

Rubinstein, P. (with Walker, M., Mollen, N., Laubenstein, L., and Friedman -Kien, A.), 

Immunogenetic findings in patients with epidemic Kaposi's Sarcoma. In: The Acquired 
Immune Deficiency Syndrome and Infections of Homosexual Men. Armstrong, D. and 
Ma, P., eds.. Chapter 25, York Medical Books., U.S.A., N Y, pp. 362-380, 1983. 

Rubinstein, P. (with Rothman, W.M., and Friedman-Kien, A.), Immunologic and immuno- 
genetic findings in patients with epidemic Kaposi's Sarcoma. Antibiot. Chemother. 
32:87-98, 1984. 

Saxena, B.B. (with Dattatreyamurty, B., and Rathnam, P.), Isolation of the luteinizing 

hormone-chorionic gonadotropin receptor in high yield from bovine corpora lutca. J. 
Biol. Chem. 258:3140-3158, 1983. 

Saxena, B.B. (with Rathnam P.), A "sandwich" solid-phase enzyme immuno-assay for 
lutropin in urine. Clin. Chem. 30:665, 1984. 

Shapiro, J R. (with Shapiro, W.R.), Clonal tumor cell heterogeneity. In: Progressive Experimental 
Brain Tumor Research, M.L. Rosenblum and C.B. Wilson, eds. Vol. 27: 49-66, Karger, 
Basel, Switzerland, 1984. 

Shapiro, J. R. (with Pu, P.-Y. , and Shapiro, W.R.). Resistant cells in human gliomas. In: Human 
Tumor Cloning, Salmon, S.E., and Trent, J. M., eds. Gome & Stratton, Orlando, 1984. 
In press. 

Silagi, S. (with Graf, L.H., Jr., and Kaplan, P.) Mediated transfer of selectable genes and un- 
selected sequences into differentiated and undifferentiated mouse melanoma clones. 
Som. Cell & Molec. Gen. 10:139-151. 1984. 

Silagi, S. (with Graf, L.H., Jr.), 5-Azacytidine induces melanin and plasminogen activator in 

amelanotic melanoma cells in culture. Proc. Xllth Int'l Pigment Cell Conf. p. 206. 1983. 

Siniscalco, M., Molecular mapping of the human genome: A crossroad between basic and 
applied research. Banbury Report 014: Recombinant DNA Application to Human 
Disease. Cold Spring Laboratory, 1983. 

Siniscalco. M (Szabo, P.. and Grzeschik, K.H.), A human autosomal phosphoglycerate 

kinase locus maps near the HLA cluster. Proc. Natl. Acad. Sci. USA, 81:3167-3169, 1984. 



19 



Siskind, G.W. (with Goidl, E.A., Choy.J.W., Gibbons, J.J. , Weksler, M.E., and Thorbccke, 
G.J.), Production of auto anti-idiotypic antibody during the normal immune response. 
VII. Analysis of the cellular basis for the increased auto anti-idiotypic antibody production 
by aged mice. J. Exp. Med. 157:1635-1645, 1983. 

Siskind, G.W. (with Xue, B., Coico, R., Wallace, D., Perms, B., and Thorbecke, G.J.), 
Physiology of IgD. IV. Enhancement of antibody production in mice bearing IgD 
secreting plasmocytomas. J. Exp. Med. 159:103-113, 1984. 

Sterner, R. (with Allfrey, V.G.), Selective isolation of polypeptide chains bearing multiple types 
of postsynthetic modifications. Recovery of simultaneously acetylated and phosphorylated 
forms of histone H2A and high mobility group proteins 14 and 17. J. Biol. Chem. 
258:12135-12138, 1983. 

Sterner R. (with Allfrey, V.G., and Sun, I.Y.-C), Affinity probes for protein acetylation and 
phosphorylation. In: Posttranslational Covalent Modification of Proteins, Johnson, B.C., 
ed. Academic Press, New York, pp. 181-203, 1983- 

Traktman, P. (with Sridhar, P., Condit, R.C., and Roberts, B.E.), Transcriptional mapping of 
the DNA polymerase gene of vaccinia virus. J. Virology 49:125-131, 1984. 

Wachtel, S.S. (with Wachtel, G.M., Nakamura, D., and Gilmour, D.), H-Y antigen in the 
chicken. Differ. 23(Suppl.):Sl07-Sll5, 1983. 

Wachtel, S.S. (with Muller, U.), On the nature of the H-Y antigen. Differ. 23(Suppl.):Sl21, 
1983. 

Wall, D.A. (with Hubbard, A.L., and Dunn, W.A.), The intracellular pathway taken by asialo- 
glycoproteins and epidermal growth factor in rat hepatocytes. In: Falk Symposium, 
Popper, H., Reutter, W., Gudat, F., and Kottgen, E., eds. MIT Press Ltd., Boston, 
Vol. 34, pp. 265-275, 1983. 

Wall, D.A. (with Steer, C.J., and Ashwell, G.), Evidence for the presence of the asialoglyco- 
protein receptor in coated vesicles isolated from rat liver. Hepatology 3:667-672, 1983. 

Weksler, B. (with Pett, S., Alonso, D., Richter, R., Stelzer, P., Subramanian, V., Tack- 
Goldman, K., and Gay, W.), Differential inhibition by aspirin of vasculature and 
platelet prostaglandin synthesis in atherosclerotic patients. New Eng. J. Med. 308: 
800-805, 1983. 

Weksler, B. (with Lewin, M.), Role of the vasculature endothelium in hemeostasis. In: Hemeo- 
static Mechanisms and Metastasis, Honn, K.V., and Sloane, B.F., eds. Martinus Nijhoff, 
1984. 

Zakim, D. (with Hochman, Y. , and Kenney, W.C.), Evidence for an active site arginine in 
UDP-glucuronyltransferase. J. Biol. Chem. 258:6430-6434, 1983. 

Zakim, D. (with Hochman, Y), Studies of the catalytic mechanism of UDP-glucuronyltransferase. 
a-glucuronidase activity and its stimulation of phospholipids. J. Biol. Chem. 259: 
5521-5525, 1984. 



20 



Field of Microbiology 
Faculty 



Kenneth I. Berns 
Francis Barany 
Robert W. Dickerman 
Thomas C. Jones 
Jan S. Keithly 
Steven R. Meshnick 
William M. O'Leary 
Richard B. Roberts 



Charles A. Santos- Buch 
Laurence B. Senterfit 
Gregory W. Siskind 
Kurt H. Stenzel 
Dieter H. Sussdorf 
Paula Traktman 
Marc E. Weksler 
Micheal E. Wiebe 



Research Activities 

Emphasis is given to the molecular biology of microorganisms as it underlies 
their replication and the mechanisms of microbial pathogenesis. 

On one hand microbes are of interest because their simplicity renders 
them attractive model systems to study in order to understand the fundamental 
processes of life. On the other hand they are of intrinsic interest as subjects of 
study both as a distinctive life form and because of their impact on other 
forms of life as parasites and /or symbionts. Because of the rapid development 
of molecular biological techniques, in particular in genetic engineering, micro- 
biologists are now in a uniquely favorable position to ask ever more meaning- 
ful and sophisticated questions about basic mechanisms and to then apply the 
answers to practical problems of infectious diseases. The interests of the faculty 
in the program in microbiology span the broad spectrum inherent in such an 
area of science as well as a broadly based comprehensive graduate scientific 
education. The specific interests of the Field faculty are outlined below. 

Studies of viruses include genome structure, replication, recombination, 
and latent infection. Additionally, gene regulation and the dependence of 
defective viruses on helper virus functions are covered. Finally use of viruses as 
recombinant vectors for the insertion of specific genes into mammalian cells is 
also being studied. 

Similar types of studies are being carried out with bacteria. Particular at- 
tention is being given to the use of bacterial plasmids as vectors and cloning 
vehicles for genetic analyses. Also at the molecular level new methods of site- 
specific mutagenesis are being developed. Special studies are directed toward 
elucidation of the mechanism of bacterial transformation. Mycoplasma are the 
subjects of studies on antigenic structure and pathogenesis. At a more applied 



21 



level are projects in clinical microbiology, in particular the instrumental char- 
acterization of bacteria. 

Fundamental studies on recombination in fungi are ongoing. Fungi are 
among the simplest of the eukaryotes and thus offer an excellent opportunity 
to define basic genetic mechanisms in cells with true nuclei. Current investiga- 
tions are both genetical and enzymological in nature and will greatly enhance 
our understanding of the basic genetic process by which two DNA molecules 
exchange nucleotide sequences and thus genetic information. 

There is an extensive research program in parasitology. The three basic 
components of the program have to do with the mechanisms of intracellular 
survival, pathogenesis and virulence, design of antiprotozoal agents and anti- 
metabolites, and the immune response to protozoal infection. 

Finally part of the program involves the host reaction to infection in 
terms of the immune response. 



Recent Publications 

Barany, F. (with Kahn, M.E., and Smith, H.O.), Directional transport and integration of donor 
DNA in Haemophilus influenzae transformation. Proc. Natl. Acad. Sci. 80:7274-7278, 
1983. 

Barany, F. (with Kahn, M.E., and Smith, H.W.), Transformasomes: Specialized membranous 
structures that protect DNA during Haemophilus transformation . Proc. Natl. Acad. 
Sci. 80:6927-6931, 1983. 

Berns, K.I. (with LeFebvre, R.B., and Riva, S.) Conformation takes precedence over sequence 
in adeno-associated virus DNA replication. Mol. & Cell. Biol. 4: 1416-1419, 1984. 

Berns, K.I. (with Grossman, Z., and Winocour, E.), Recombination between simian virus 40 
and adeno-associated virus: Virion coinfection compared to DNA cotransfection. Virol. 
134:125-137, 1984. 

Dickerman, R.W. (with Scherer, W.F.), Equine herds as sentinels for Venezuelan equine 

encephalitis virus activity, Nicaragua 1977. Bull. Pan. Am. Health Org. 117:14-18, 
1983. 

Dickerman, R.W. (with Boyle, D.B., and Marshall, I.D.), Primary antibody responses of herons 
to experimental infection with Murray Valley encephalitis and Kunjin viruses. Aust. J. 
Exp. Biol. Med. Sci. 61:665-674, 1983. 

Jones, T.C. (with Ebrahimzadeh, A.), A comparative study of different Leishmania tropica 

isolates from Iran: Correlation between infectivity and cytochemical properties. Am. J. 
Trop. Med. Hyg. 32:694, 1983. 

Keithly, J.S. (with Langreth, S.G.), Inefficacy of metronidazole in experimental infections of 

Leishmania donovani, L. mexicana, and trypanosoma brucei brucei. Am. J. Trop. Med. 
Hyg. 32:485-496, 1983. 

Keithly, J.S. (with Fong, D., Wallach, M., Melera, P.W., and Chang, K.-P ), Differential 

expression of mRNA's for and tubulin during differentiation of a parasitic protozoan 
Leishmania mexicana . Proc. Natl. Acad. Sci. 81, 1984. 



22 



Meshnick, S R. (with Trang, N.L., Kitchener, K., Eaton, J. W., and Cerami, A.), Iron-containing 
superoxide dismutasc from Cnthidia fasciculata: Punfitation. characterization and 
similarity to leishmanial and trypanosomal enzymes. J. Biol. Chcm. 258:125-130, 1983. 

Meshnick, S.R. (with Fairfield, A.J., and Eaton, J. W), Malaria parasites adopt host cell super- 
oxide dismutasc. Science 221:764-766, 1983. 

Roberts, R.B. (with Francioli, P., Shio, H., and Muller, M ), Phagocytosis and killing of Neisseria 
gonorrhoeae by Trichomonas vaginalis.). Inf. Dis. 147:87-94, 1983. 

Roberts, R.B. (with Murray, H.W., Rubin, B.Y., and Masur, H.), Impaired production of 

lymphokincs and immune (gamma) interferon in the acquired immunodeficiency syn- 
drome. New Eng. J. Med. 310:883, 1984. 

Santos-Buch, C.A. (with Acosta, A.M., and Sadiqursky. M.), Anti-striated muscle antibody 
activity produced by Trypanosoma cruzi. Proc. Soc. Exp. Bio. & Med. 172:364-369, 
1983. 

Santos-Buch, C.A. (with Chess, Q., Acosta, A.M., and Sethi, J. K.), Reversible acquisition of 
host cell surface membrane antigen by Trypanosoma cruzi. Infect. Immun. 40(1): 
299-302, 1983. 

Senterfit, L.B., Tetrazolium Reduction Inhibition. In: Methods of Mycoplasmology. Razin, S. 
and Tully, J., cds. Academic Press, New York, pp. 419-422, 1983. 

Senterfit, L B. (with Lcith, D.K., Trevino, L.B., Tully, J. G., and Baseman, J. B.), Host 

discrimination of Mycoplasma pneumoniae proteinaceous immunogens. J. Exp. Med. 
157:502-514. 1983. 

Siskind, G.W. (with Goidl, E.A., Choy, J.W.. Gibbons, J.J. , Weksler, M.E., and Thorbecke, 
G.J.). Production of auto-anti-idiotypic antibody during the normal immune response. 
VII. Analysis of the cellular basis for the increased auto-anti-idiotype antibody produc- 
tion by aged mice. J. Exp. Med. 157:1635-1645, 1983. 

Siskind, G.W. (with Xue, B., Coico. R., Wallace, D., Pernis, B. and Thorbecke, G.J.), 
Physiology of IgD. IV. Enhancement of antibody production in mice bearing IgD 
secreting plasmacytomas. J. Exp. Med. 159:103-113, 1984. 

Stenzel, K.H. (with Lipkowitz, S., Green, W.C., Rubin, A.L., and Novogrodsky, A.), 

Expression of receptors for interleukin 2: Role in the commitment of T lymphocytes to 
proliferate. J. Immunol. 132:31, 1983. 

Stenzel, K.H. (with Suthanthiran, M., Solomon, S.D., William, P.S., Rubin, A.L., and 

Novogrodsky. A ), Hydroxy! radical scavengers inhibit human natural killer cell activity. 
Nature 307:276, 1984. 

Traktman, P. (with Sridhar, P., Condit, R.C., and Roberts, B.E.), Transcriptional mapping of 
the DNA polymerase gene of vaccinia virus. J. Virology 49: 125-131, 1984. 

Weksler, M E. (with Hausman, P.B. , Moody, C.E. , Innes, J.B. , and Gibbons, J. J.), Studies on 
the syngeneic mixed lymphocyte reaction. III. Development of a monoclonal antibody 
with specificity for autoreactive T cells. J. Exp. Med. 158:1307, 1983. 

Weksler, M E. (with Gutowski, J.K. , Innes, J., and Cohen, S ), Induction of DNA synthesis in 
isolated nuclei by cytoplasmic factors. II. Normal generation of cytoplasmic stimulatory 
factors by lymphocytes from aged humans with depressed proliferative responses. J. 
Immunol. 132:559, 1984. 

Wiebe, M E. (with Schcrer, W.F.. and Peick. W.J.). Marker characteristics of Venezuelan 

encephalitis virus strains isolated before and after epidemics and equine epizootics in 
Middle America. Am. J. Epidemiol. 117:201-212, 1983. 



23 



Wiebe, M.E. (with Nathan, C.F. , Murray, H.W. , and Rubin, B.Y.), Identification of interferon- 
gamma as the lymphokine that activates human macrophage oxidative metabolism and 
antimicrobial activity. J. Exp. Med. 158:670-689, 1983. 



Field of Neurobiology and Behavior 

Faculty 

Harriet D. Baker 
Ira B. Black 
Dana C. Brooks 
Arthur J. L. Cooper 
Cheryl Dreyfus 
Daniel Gardner 
Michael S. Gazzaniga 
James G. Gibbs, Jr. 
Gary E. Gibson 
Bernice Grafstein 
Wilbur D. Hagamen 
{Catherine A. Halmi 
Tong H. Joh 
David E. Levy 



Research Activities 

The Field emphasizes a multidisciplinary approach to the study of the nervous 
system since recent advances in the field of neuroscience have mainly required 
multiple approaches. The research interests of the faculty are diverse, but 
overlap and include the following. 

(1) Molecular neurobiology and neuronal plasticity during growth and 
development; this includes biochemical and molecular biological approaches 
to the development and phylogeny of the nervous system, and mechanisms 
governing differentiation and phenotypic expression of neurotransmitter 
enzymes and peptides in the central and peripheral nervous systems. 

(2) Growth of nerve and axonal transport of materials; this includes bio- 
chemical and physiological studies of optic nerve regeneration and axonal 
transport in non-mammalian systems. 



Hong M. Moon 
Michiko Okamoto 
Virginia M. Pickel 
Fred Plum 
Donald J. Reis 
Walter F. Riker, Jr. 
David A. Rottenberg 
David A. Ruggiero 
Jeri A. Sechzer 
Gerard P. Smith 
Peter E. Stokes 
Gladys N. Teitelman 
Robert Young 



24 



(3) Regeneration and degeneration in the central nervous system: the 
focus is on the molecular mechanisms governing retrograde reaction, regenera- 
tion, degeneration and neuronal cell death in the central nervous system. 

(4) Molecular genetics of neurospecific proteins, neurotransmitter enzymes 
and receptors; this includes structural analysis of genes coding for these pro- 
teins, gene regulation of autonomic neurons, including gene cloning, DNA 
sequencing, and quantitative analysis of transcription and translation. 

(5) Biochemistry of amino acids, alpha-keto acids and energy metabolism 
in the brain; the emphasis is on suicide inhibitors and mechanisms to trans- 
port reducing equivalents, as well as on the use of positron emitting com- 
pounds to assess brain metabolism in man. 

(6) Relation of oxidative, calcium and neurotransmitter metabolism dur- 
ing various disease states, including nutritional disorders, aging, hypoxia and 
Alzheimer's disease; these interactions are examined with rodent brains in 
vivo and in vitro, as well as with cultured skin fibroblasts from humans. 

(7) Positron emission tomography of the human central nervous system; 
the metabolism and physiology of the nervous system, intracellular pH and 
other measures of cerebral function as assessed with a variety of positron 
emitting compunds. 

(8) Central regulation of autonomic nervous system: central neuronal 
regulation of cerebral blood flow and metabolism, and neuroanatomical 
substrates of cardiovascular regulation. 

(9) Synaptic organization of networks of identified neurons: biophysics of 
synaptic transmission. 

(10) Neuropharmacology of sedative-hypnotic drug dependence. 

(11) Cytochemistry and histochemistry of neurons; the studies include 
ultrastructural identification of synaptic interactions of brain; immunocyto- 
chemistry of nervous specific protein, peptides and neurotransmitter enzymes, 
and quantitative analysis of enzyme expression by immunohistochemistry. 

(12) Neuroendocrine mechanisms of feeding behavior, motivated behavior, 
human disorders of eating, and of depression and psychiatric disorders; these 
studies include examination of the interaction of neurotransmitters and their 
relation to behavioral states. 

(13) Neural mechanisms of learning and memory and neurobehavioral 
toxicology. 

(14) Antidepressants; their effects on brain amine neurotransmitters and 
behavior in young adult and the elderly. 

(15) Neuropsychological approaches to behavior; these studies emphasize 
that human brain dysfunction provides a unique vantage point for studying 
mechanisms of preception, memory, attention and language. 



25 



Recent Publications 



Baker, H. (with Kawano, T., Albert, V.R., Joh, T.H., Reis, D.J., and Margolis, F.L.), Olfactory 
bulb dopamine neurons survive deafferentation -induced loss of tyrosine hydroxylase. 
Neuroscience 11:605-615, 1984. 

Cooper, AJ.L. (with Fitzpatrick, S.M., and Duffy, T.E.), Use of B-methylene-D, L-aspartate to 
assess the role of aspartate aminotransferase in cerebral oxidative metabolism. J. 
Neurochem. 41 (5): 1370-1383, 1983. 

Dreyfus, C. (with Markey, K.A., Goldstein, M., and Black, I.B.), Development of catechola- 
minergic phenotypic characters in mouse locus coeruleus in vivo and in culture. Dev. 
Biol. 97:48-58, 1983. 

Gardner, D. (with Ruff, R.L., and White, R.L.), Choline acts as agonist and blocker for Aplysia 
cholinergic synapses. J. Neurophysiol. 51:1-15, 1984. 

Gibbs, J. (with Smith, G.P.), The neuroendocrinology of postprandial satiety. In: Frontiers in 
Neuroendocrinology, Vol. 8, Martini, L., and Ganong, W.F., eds. Raven Press, New 
York, 1984, pp. 223-245. 

Gibbs, J. (with Kraly, F.S., and Miller L.A.), Diurnal variation for inhibition of eating by 
bombesin in the rat. Physiol. Behav. 31:395-399, 1983. 

Gibson, G.E. (with Peterson, C), Amelioration of Age-Related Deficit in Acetylcholine Release 
and Behavior with 3,4-Diaminopyridine. In: Aging of the Brain, Samuel, D., Algeri, S., 
Gershon, S., Grimm, V., and Toffano, G., eds. Raven Press, New York, pp. 337-348, 
1983. 

Gibson, G.E. (with Peterson, C), Synaptosomal calcium metabolism during hypoxia and 
3,4-diaminopyridine treatment. J. Neurochem. 42:248-253, 1984. 

Graftstein, B. (with Edwards, D.L.), Intraocular tetrodotoxin in goldfish hinders optic nerve 
regeneration. Brain Res. 269:1-14, 1983. 

Grafstein, B. (with Whitnall, M.H.), Changes in perikaryal organelles during axonal regenera- 
tion in goldfish retinal ganglion cells: an analysis of protein synthesis and routing. Brain 
Res. 272:49-56, 1983. 

Halmi, K.A. (with Owen, W.P., Lasley, E., and Stokes, P.), Dopamine regulation in anorexia 
nervosa. Psychopharmacol. Bull. 19:578-579, 1983. 

Joh, T.H. (with Baetge, E.E., Moon, H.M., Kaplan, B.B., Park, D.H., and Reis, D.J.), 
Identification of clones containing DNA complementary to phenylethanolamine 
N-methyltransferase mRNA. Neurochem. Intl. 5(5):6l 1-617, 1983. 

Joh, T.H. (with Baetge, E.E., Ross, M.E., and Reis, D.J.), Evidence for the Existence of 

Homologous Gene Coding Regions for the Catecholamine Biosynthetic Enzymes. In: 
Cold Spring Harbor Symposia on Quantitative Biology, Vol. 48, Watson, J. D., and 
McKay, R., eds. Cold Spring Harbor Laboratory, pp. 327-335, 1983. 

Levy, D.E. (with Caronna, J.J.), Clinical predictors of outcome in ischemic stroke. In: Sympo- 
sium on Cerebrovascular Disease, Vol. 1, Barnett, H.J.M., ed. W.B. Saunders Co., 
Philadelphia, pp. 103-117, 1983. 

Okamoto, M. (with Hinman, D.J.), Sleep patterns in cats during chronic low-dose barbiturate 
treatment and withdrawal. Sleep 7:69-76, 1984. 

Pickel, V.M. (with Joh, T.H., Chan, J., and Beaudet, A.), Serotonergic terminals: ultrastructure 
and synaptic interaction with catecholamine containing neurons in the medial nuclei of 
the solitary tracts. J. Comp. Neurol. 225:291-301, 1984. 



26 



Picket . V.M. (with Milncr, T.A., Joh. T.H . Miller, R.J.), Substance P. neurotensin, enkephalin, 
and catecholamine synthesizing enzymes: light microscopic localizations compared with 
autoradiographic label in solitary efferents to the rat parabrachial region. J. Comp 
Neurol. 226:434-444, 1984. 

Plum. F (with Duffy, T.E., and Cooper, A.J.L.), Cerebral ammonia metabolism in vivo. In: 

Metabolic Relationship between Glutamine, Glutamate and GABA in the CNS, Herz, L., 
el aJ., eds. Alan R. Liss, New York, pp. 371-388, 1983. 

Reis, D.J. (with Fink, J. S., and Baker, H.), Genetic control of the number of dopamine 

neurons in the brain: Relationship to behavior and responses to psychoactive drugs. In: 
Genetics of Neurological and Psychiatric Disorders, Assn. for Research in Nervous and 
Mental Diseases, Kcty, S.S., et a!., eds. Raven Press, New York, pp. 55-75, 1983. 

Reis, D.J., Central neural control of cerebral circulation and metabolism. In: Neurotransmitters 
and the Cerebral Circulation, Vol. 2, Bcs, A., McKenzie, E.T., and Seylaz, J., eds. 
Raven Press, New York. 1984, in press. 

Rottenberg, D.A. (with Ginos.J.Z., Kearfott, K.J.Junck, L.R., and Bigner, D.D.), In vivo 
measurement of regional brain tissue pH using positron emission tomography. Ann. 
Neurol. 15(Supl):S98-Sl02. 1984. 

Rottenberg, D.A., Intracranial hypotension, intracranial hypertension, pseudotumor cerebri, 

hydrocephalus. In: Cecil Textbook of Medicine, 17th Edition, Wyngaardcn, J.B. , Smith, 
L.H.. and Plum, F., eds. W.B. Saunders Co . Philadelphia, in press. 

Sechzer, J.A., The ethical dilemma of some classical animal experiments. (Role of Animals in 
Biomedical Research 406) Ann. NY Acad. Sci. pp. 5-12, 1984. 

Sechzer. J. A. (with Zola, J. C. Sieber.J.E., and Griffin, A ), Animal experimentation: Issues 
for the 1980s. In: Science, Technology and Human Values, Vol. 9, Issue 2, John Wiley 
& Sons, pp. 40-50. 1984. 

Smith, G.P., Gut hormone hypothesis of postprandial satiety. In: Eating and Its Disorders, 
Stunkard, A.J., and Stellar, E., eds. Raven Press, New York, pp. 67-75, 1984. 

Smith, G.P. (with Gibbs, J ), The neuroendocrinology of postprandial satiety. In: Frontiers in 
Neuroendocrinologv, Vol. 8, Martini, L., and Ganong, W.F., eds. Raven Press, New 
York, pp. 223-245, 1984. 

Stokes, P.E. (with Bossom, J., Natelson, B.H., and Levin, B E ), Ultradian rhythms in cognitive 
functions and their relationship to visceral processes. Physiol. Bchav. 31:119-123, 1983. 

Stokes, P.E. (with Stoll. P.M.. Koslow, S.H.. Maas.J.W., Davis, J. M., Swann AC, and 

Robins. E ), Prctreatment DST and hypothalamic-pituitary-adrenocortical function in 
depressed patients and comparison groups. Arch. Gen. Psychiatry 41:257-267. 1984. 

Teitelman, G. (with Iacovitti. L..Joh, T.H., and Reis. D.J.), Ontogenesis of fetal catecholamine 
biosynthesis. Excerpta Medica. 1984, in press. 

Young, R C. (with Alexopoulos. G.S.. Shamoian, C.A.. Manley, M.W.. Dhar, A.K., and 
Kutt, H ), Plasma 10-hydroxynortriptyline in elderly depressed patients. Clin. Phar- 
macol. Ther. 35 (4):540-544, 1984. 

Ruggiero, D.A. (with Baker. H ..Joh. T.H., and Reis. D.J.), Distribution of catecholamine 
neurons in the hypothalamus and preoptic region of mouse. J. Comp. Neurol. 223: 
556-582, 1984. 



11 



Field of Pathology 



Faculty 

Daniel R. Alonso 
Carl G. Becker 
Peter G. Bullough 
John T. Ellis 
David Hajjar 
Aaron Kellner 
C. Richard Minick 



Carol K. Petito 
Margaret J. Polley 
Alfred M. Prince 
Charles A. Santos-Buch 
Laurence B. Senterfit 
Marc E. Weksler 



Research Activities 

Research activities in the Field of Pathology include both basic and clinical 
research into the mechanisms and natural history of disease. 

The principal research activities of the department are directed to the 
study of cardiovascular disease and how basic pathophysiologic processes such 
as inflammation, blood coagulation and perturbation of the immune system 
and its regulation contribute to arteriosclerosis and its complications and the 
pathogenesis of Chagas' Disease, or South American trypanosomiasis. Together, 
these diseases are the major causes of cardiovascular deaths worldwide. 

Much of the research is carried out within the Department of Pathology, 
but involves extensive collaboration with investigators in other disciplines, in- 
cluding especially immunology and hematology. We are convinced that this 
interdisciplinary approach is essential to understanding disease mechanisms 
and also provides a unique opportunity to graduate students by increasing 
the intellectual diversity of the research program. 

Because the Department of Pathology is also responsible for the clinical 
laboratory services of The New York Hospital, most of the faculty also have 
clinical responsibilities. We regard this as a major research resource because 
problems relating to the diagnosis, etiology, and mechanisms of progression 
of disease processes arise constantly. Presentation and discussion of these make 
up an important part of the educaitonal conferences within the department 
and of the course in Pathology. They also provide a never ending source of 
subjects and ideas for both basic and applied research. 



28 



Recent Publications 

Alonso, D.R. (with Fernandes, G., Tanaka, T., ct al.). Influence of diet on vascular lesions in 
autoimmune-prone mice. Proc. Natl. Acad. Sci. 80:874-877, 1983. 

Alonso, D.R. (with Weksler, B.B., Pett, S.B., et al.), Differential inhibition by aspirin of 
vascular and platelet prostaglandin synthesis in atherosclerotic patients. N.J. Med. 
308:800-808, 1983. 

Becker, C.G. (with Francus, T., and Siskind, G.W.), The role of antigen structure in the 
regulation of IgE isotype expression. Proc. Natl. Acad. Sci. 80:3430-3434, 1983 - 

Bullough, P.G. (with Nakata, K.), The injury and repair of human articular cartilage: A 

morphological study of 192 cases of coxarthrosis. J. Rheumatol. 10(S9):72-73, 1983. 

Bullough, P.G. (with Jagannath, A ), The morphology of the calcification front in articular 
cartilage. J. Bone Joint Surg. 65-B:72-78, 1983. 

Ellis, J. T. (with Peterson, P.) Myelofibrosis in the myeloproliferative disorders. In: Myelofibrosis 
and the Biology of Connective Tissue, Berk, P.D., Casto-Malaspina, H., and Wasserman, 
L.R., eds. Alan R. Liss, Inc., New York, 19-42, 1983. 

Hajjar, D P. (with Weksler, B.B.), Metabolic activity of cholesteryl esters in aortic smooth 

muscle cells is altered by prostaglandins I 2 and E 2 . J. Lipid Res. 24:1176-1185, 1983. 

Hajjar, D P. (with Minick, C.R., and Fowler, S.D.), Arterial neutral cholesteryl esterase: A 

hormone-sensitive enzyme distinct from lysosomal cholesteryl esterase. J. Biol. Chem. 
258:192-198, 1983. 

Minick, C.R. (with Becker, C.G.), Environmental risk factors and vascular disease. U.S. E.P.A. 
600.8/83/002:136-174, 1983. 

Santos-Buch, C.A. (with Chess, Q., Acosta, A.M., and Sethi, J. K.), Reversible acquisition of a 
host cell surface membrane antigen bv Trypanosoma cruzi. Infection and Immunity 
40:299-302, 1983. 

Santos-Buch, C.A. (with Acosta, A.M., and Sadigursky, M.), Anti-striated muscle antibody 

activity produced by Trypanosoma cruzi. Proc. Soc. Exp. Biol, and Med. 172:364-369, 
1983. 

Senterfit, L B. (with Leith, D.K., Trevino, L.B., Tully.J.G., and Baseman, J. B.), Host deter- 
mination of Mycoplasma pneumoniae proteinaceous immunogens. J. Exp. Med. 157: 
502-515, 1983. 

Senterfit, L B. (with Toth, A., and Ledger, W.J.), Secondary amenorrhoea associated with 
Chlamydia trachomatis infection. Brit. J. Ven. Dis. 59:105-108, 1983. 



Field of Pharmacology 



Faculty 



Walter W.Y. Chan 
Diane F. Felsen 
Owen W. Griffith 



Michiko Okamoto 
Gavril W. Pasternak 
Marcus M. Reidenberg 



29 



Raymond W. Houde 
Charles E. Inturrisi 
Robert F. Kaiko 
Roberto Levi 



Arlene Rifkind 
Walter F. Riker, Jr. 
Hazel H. Szeto 



Research Activities 

The faculty in the Field of Pharmacology engage in a diverse range of 
research. This affords an unusual breadth of opportunity for training. The 
principal research areas are: 

Analgesic and Opioid Pharmacology : Research on narcotic and non- 
narcotic analgesic drugs extends from the molecular (receptor) level to the 
clinical level. Analgesics under investigation include the opioids, the 
cannabinoids, nonsteroidal antiinflammatory drugs and endorphins. Ongoing 
projects include development of new and sensitive methods for pharmacokinetic 
studies of parent drugs and their metabolites, characterization of subclasses of 
opioid binding sites and clinical trials of novel analgesics. 

Biochemical Pharmacology and Toxicology : Polyhalogenated hycrocarbon 
toxicities are the focal point of study. Susceptibility of organisms to chemical 
toxicity during embryonic development, the role of cytochrome P-450 
mediated mixed function oxidase and the arachidonate metabolites in the 
production of toxicity are being investigated. 

Cardiovascular Pharmacology: The research in cardiovascular pharma- 
cology covers two areas. One is on the role of cardiovascular dysfunctions in 
immediate hypersensitivity reactions and the other is on the clinical pharma- 
cology of antiarrhythmic drugs. The heart is studied as a target organ in 
immunologic hypersensitivity reactions. The role of chemical mediators such 
as histamine, platelet activating factors, prostaglandins, leukotrienes and 
other arachidonate metabolites in immunologic hypersensitivity reactions are 
investigated in both human and sub-human cardiac tissues. Clinical trials of 
antiarrhythmic drugs include procainamide and its metabolite N-acetyl- 
procainamide, quinidine and lidocaine metabolites. Pharmacokinetics of these 
drugs and their principal metabolites are determined. Therapeutic efficacy 
and safety of these antiarrhythmics are evaluated in cardiac patients of various 
ages. 

Endocrine and Renal Pharmacology: The research activities center on the 
interactions between the neurohypophysial hormones and prostaglandins in 
the uterus and the kidney. The role of oxytocin and prostaglandins in the 
genesis of preterm labor and the development of specific oxytocin antagonists 
as potential agents for the prevention of preterm labor are the major foci of • 
research. Ongoing projects also include the study of the physiology of prosta- 



30 



glandins in primary dysmenorrhea and the pharmacology of nonsteroidal 
antiinflammatory drugs in the treatment of this menstrual dysfunction. 

The pharmacology of natriuretic neurohypophysial peptides and their 
ability to release intrarenal prostaglandins are also being studied to evaluate 
their potential as antihypertensive agents. The metabolism and function of 
arachidonic acid and its metabolites in the kidney and the liver, and the role 
of thromboxane A2 in the pathology of unilateral ureteral obstruction are 
being actively pursued. Other current projects include investigation of the 
role of arachidonic acid metabolites in hypertension and in salt and water 
balance and studies of the function of hepatic enzymes and various hepatic 
cell types in the metabolism of arachidonic acid. 

Neuropharmacology: Studies on the neuropharmacology of nerve endings 
center on the mechanisms of drug action on neurones, neuronal processes and 
synaptic systems in both the peripheral and central nervous system. Current 
work is concerned with the pharmacologic and functional characterization of 
motor nerve terinals innervating tonic and phasic skeletal muscle. Pharma- 
cologic probes are employed for the definition of cholinergic sites on these 
motor nerve terminals and for the testing of the hypothesis that the primary 
anticurate and anti-myasthenic actions of facilitatory drugs are exerted pre- 
junctionally by an action on slow current channels. The role of flucocorticoids 
in motor nerve ending function is being investigated. The possibility that 
steroids play a role in maintaining presynaptic function in the nervous system 
will be a focal point of study. 

Another major area of study is the pharmacologic and neuropharmacologic 
bases of the physical dependence and withdrawal caused by general CNS de- 
pressants. Barbiturates and alcohol are the prototypes for study. A quantitative 
methodology for the pharmacologic characterization of physical dependence 
on these CNS depressants in animal models has been perfected in this labora- 
tory. The approach to research is multidisciplinary involving a wide range of 
laboratory techniques including modern chromatographic methods for deter- 
mination of drugs in biofluids and electrophysiologic techniques for monitor- 
ing central and peripheral neuronal responses. 

Pre- and Neonatal Pharmacology: The primary research interest is the 
study of maternal-fetal pharmacokinetics and pharmacodynamics. The 
pregnant sheep provides a model for studying, throughout the last trimester, 
the relative roles of the placenta and the fetus in determining the extent of 
fetal exposure of maternally administered drugs. The research involves 
mathematical modeling of the maternal-fetal unit, the determination of drug 
clearances by the placenta and by the fetus in utero, and the ontogenesis of 
the fetal drug-metabolizing capacity. 



31 



Recent Publications 



Chan, W.Y. , Uterine and placental prostaglandins and their modulation of oxytocin sensitivity 
and contractility in the parturient uterus. Biol. Reprod. 29:680-688, 1983. 

Chan, W.Y. (with Powell, A.M.), Differential effects of ibuprofen and naproxen sodium on 
menstrual prostaglandin release and on prostaglandin production in the rat uterine 
homogenate. Prostaglandins, Leukotrienes and Medicine 13:129-137, 1984. 

Felsen, D. (with Vaughan, E.D., Jr.), Endocrine function of the renal parenchyma. In: Urologic 
Endocrinology, ed. byj. Rafer, 1983. 

Houde, R.W. (with Kaiko, R.F., Wallenstein, S.L., and Rogers, A.G.), Sources of variation in 
analgesic responses in cancer patients with chronic pain receiving morphine. Pain 15: 
191-200, 1983. 

Houde, R.W. (with Inturrisi, C.E., Max, M.B., Foley, K.M., Schultz, M., and Shin, S.U.), The 
pharmacokinetics of heroin in patients with chronic pain. N. Eng. J. Med. 310 (19): 
1213-1217, 1984. 

Inturrisi, C.E. (with Schultz, M., Shin, S., Umans, J., Angel, L., and Simon, E.J.), Evidence 
from opiate binding studies that heroin acts through its metabolites. Life Sci. 33: 
Suppl. 1, 773-776, 1983. 

Inturrisi, C. (with Dixon, R., Crews, T., and Foley, K.), Levorphanol: Pharmacokinetics and 
steady-state plasma concentrations in patients with pain. Res. Comm. Chem. Path. 
Pharmacol. 41:3-17, 1983. 

Kaiko, R.F. (with Foley, K.M., Grabinski, P.Y., Heidrich, G., Rogers, A.G., Inturrisi, C.E., 
and Reidenberg, M.M.), Central nervous system excitatory effects of meperidine in 
cancer patients. Ann. Neurol. 13:180-185, 1983. 

Kaiko, R.F. (with Wallenstein, S.L., Rogers, A.G., and Houde, R.W.), Sources of variation in 
analgesic responses in cancer patients with chronic pain receiving morphine. Pain 
15:191-200, 1983. 

Levi, R. (with Guo, Z.-G., Aaronson, L.M., and Gay, W.A.), The isolated human pectinate 
muscle: A reliable preparation of human cardiac tissue. J. Pharmacol. Methods 
9:127-135, 1983. 

Levi, R. (with Trzeciakowski, J.P.), Antihistamines. In: Allergy: Principles and Practice. 2nd 
Edition, E. Middleton, Jr. , C.E. Reed, and E.F. Ellis, eds. St. Louis: Mosby, pp. 575- 
592, 1983. 

Okamoto, M. (with Aaronson, L.A., and Hinman, D.J.), Comparison of effects of diazepam on 
barbiturate and on ethanol withdrawal. J. Pharmacol. Exp. Ther. 225: 589-594, 1983. 

Okamoto, M. (with Hinman, D.J.), Sleep patterns in cats during chronic low-dose barbiturate 
treatment and withdrawal. Sleep 7:69-76, 1984. 

Pasternak, G.W. (with Gintzler, A.R., Houghten, R.A., Ling, G.S.F., Goodman, R.R., 

Spiegel, K., Nishimura, S., Johnson, N., and Recht, L.D.), Biochemical and pharma- 
cological evidence for opioid receptor multiplicity in the central nervous system. Life Sci. 
Suppl. I. 33:167-173, 1983. 

Pasternak, G.W. (with Nishimura, S.L., and Recht, L.D.), Biochemical characterization of high 
affinity 3H-opioid binding: further evidence for mui sites. Mol. Pharmacol. 25: 29-37, 
1984. 

Reidenberg, M.M., Aromatic amines and the pathogenesis of lupus erythematosus. Amer. J. 
Med. 75:1037-1042, 1983. 



32 



Rcidenberg, M M. (with Draycr, D.E., Lorenzo, B., and Werns. S ), Plasma level, protein- 
binding, and elimination data for lidocaine and active metabolites in cardiac patients of 
various ages receiving lidocaine Clin Pharmacol. Ther. 34: 14-22, 1983. 

Rifkind, A.B. (with Muschick, H ), Bcnoxaprofen protects against polychlorinated biphenyl 
toxicity without altering mixed function oxidase function. Nature 303:524-526, 1983- 

Rikc r. W.F. . Beneficial action of glucocorticoid treatment on neuromuscular transmission 
during early motor nerve degeneration. Exp. Neurol. 79:488, 1983. 

Szeto, H.H., Effects of narcotic drugs on fetal behavioral activity: Acute methadone exposure. 
Am. J. Obstet. Gynecol. 146:211-217, 1983. 

Szeto, H.H. (with Umans, J.G.), Effects of opiates on fetal behavioral activity in utero. Life 
Sciences 33:639-644, 1983. 



Research Activities 

Dr. Erich Windhager 's studies are centered on the elucidation of mechanisms 
of transport of ions by renal epithelial cells. Recently, he found that cytosolic 
Ca ion activity modulates membrane permeability to Na ions and that the 
level of this ion in the cell may be an important regulator of overall Na trans- 
port by kidney cells. The techniques used in Dr. Windhager's laboratory in- 
clude: isolated perfused renal tubule segments, intracellular measurement of 
ions by ion selective electrodes, electrophysiological techniques, isolated 



Field of Physiology and Biophysics 
Faculty 



Olaf S. Andersen 
William A. Briscoe 
Walter W.Y. Chan 
Colin Fell 
Gustavo F. Frindt 
Daniel Gardner 
Marvin C. Gershengorn 
Bernice Grafstein 
Roger L. Greif 



Martin Lipkin 
Thomas M. Maack 
Daniel Nachshen 
Lawrence Palmer 
Thomas G. Pickering 
Enrique M. Rabellino 
Barbara Rayson 
Henry Sackin 
John L. Stephenson 
Bernd W. Urban 
Allan M. Weinstein 
Erich E. Windhager 



Chin Ok Lee 
Roberto Levi 
Chiann-Tso Lin 



33 



membrane techniques and renal physiological techniques. Collaborating with 
Dr. Windhager are Drs. Heinz, Frindt and Lin. 

Dr. Grafstein investigates nerve regeneration and transport of material in 
nerve axons. She is presently studying regeneration of goldfish optic nerve. 
Some of the conclusions reached in the past years are: drugs that disrupt 
microtubules produce metabolic effects in axons which resemble those pro- 
duced by axotomy; application to the nerve cell body of a drug that increases 
cyclic nucleotide synthesis promotes regeneration; increased synthesis of most 
transported proteins occurs during regeneration. Among others, Dr. Grafstein 
uses the following techniques: isotope tracer studies, electronmicroscopy, high 
resolution autoradiography, and biochemical techniques for identification of 
substances present in the nerve. 

Dr. Maack studies quantitative aspects and mechanisms of renal handl- 
ing of proteins. Main recent findings conclude that the disposal of absorbed 
proteins is dependent on an appropriate acid pH of lysosomes and that the 
absorption of albumin is a high capacity-low affinity endocytic transport pro- 
cess. In addition, he determined the functional characteristics of atrial 
natriuretic factor (ANF), a substance present in the heart which decreases 
blood pressure and increases salt excretion by the kidney. The techniques 
used in Dr. Maack's laboratory include: isolated perfused rat kidney, isolated 
tubule segments, and biochemical and physiological techniques. 

Dr. Andersen is interested in the mechanisms by which ions cross mem- 
branes. His studies entail analysis of single channel permeability in lipid 
bilayers, with emphasis on the physical and chemical properties of proteins 
which serve as channels. Recently, Dr. Andersen succeeded in reconstituting 
Na channels obtained from brain tissue into lipid bilayers. Techniques used in 
Dr. Andersen's laboratory include: single channel analysis, electrophysiological 
measurements, and physio-chemical analysis. 

Dr. Fell studies vasomotility and the action of drugs such as norepi- 
nephrine and acetyl choline in this process. He uses the technique of intravital 
microscopy of small arteries of the ear of rabbits and rats. 

Neurophysiological studies of Dr. Gardner center on synaptic transmis- 
sion. Recent discoveries were: 1) choline activates inhibitory acetylcholine re- 
ceptors of Aplysia buccal ganglia, and 2) in one class of neurons, cholinergic 
postsynaptic potentials have dual-function, with early excitatory and late in- 
hibitory phases. Techniques used in Dr. Gardner's laboratory include: electro- 
physiological methods and computer analysis. 

Dr. Lee investigates mechanisms of cardiac conduction and contractility. 
He recently discovered that cardiac glycosides increase cardiac contractility by 
changing activities of calcium ions in isolated cardiac cells. Techniques used in 
Dr. Lee's laboratory include: isolated Purkinje fibers and intracellular record- 
ings with ion selective electrodes. 

Dr. Palmer's research focuses on the mechanism of transepithelial Na re- 



34 



absorption by tight epithelia. and the control of this process by hormones and 
other factors. The nature of the transport system facilitating sodium move- 
ment across the apical membrane of epithelial cells is being elucidated using 
the toad urinary bladder as a model epithelium. Techniques used in Dr. 
Palmer's laboratory include: current-voltage analysis, flux ratio analysis, patch- 
clamping, and electrophysiological techniques. 

Dr. Nachshen's laboratory studies fundamental properties of presynaptic 
nerve terminals. Since calcium entry into the nerve terminal triggers the 
release of neurotransmitter substances. Dr. Nachshen is studying the detail of 
this process and how internal pH and intracellular calcium are related to 
neurosecretion. Techniques used in Dr. Nachshen's laboratory include: use of 
pinched-off nerve endings (synaptosomes), measurements of intracellular 
calcium with optical indicator substances. 

Dr. Ray son's research activities center on the investigation of the regula- 
tion of Na-K/ ATPase (Na pump) in kidney cells. Recent discovery include the 
finding that intracellular Na levels regulate the number of active Na-K/ 
ATPase enzyme sites in outer medullary tubular segments of the kidney. 
Techniques used in Dr. Rayson's laboratory include: suspension of tubular 
segments of the kidney, biochemical techniques, and NMR. 

Dr. Urban studies the effects of general anesthetics on peripheral nerve 
(squid giant axon). He is investigating the mechanism by which anesthetics 
change sodium and potassium currents in nerves and in this manner alter 
nerve conductivity. Techniques used in Dr. Urban's laboratory include: patch- 
clamping, electrophysiological techniques and lipid bilayers. 

Dr. Weinstein is developing a mathematical model of proximal tubular 
function. He uses mathematical modeling and computer techniques. 



Recent Publications 

Andersen, O.S., Ion movement through gramicidin A Channels. Interfacial polarization effects 
on single-channel current measurements. Biophys. J. 41:135-146, 1983. 

Andersen, O.S., Ion movement through gramicidin A channels. Studies on the diffusion- 
controlled association step. Biophys. J. 41:147-165, 1983 

Frindt. G. (with Windhager, E E ), The role of cytosolic Ca J * in renal tubular transport. Pro- 
ceedings of the IX International Congress of Nephrology, Los Angeles, Calif., 1984, 
in press. 

Frindt, G. (with Windhager. E E ), Role ofCa** as a regulator of Na * permeability in 
epithclia. In: Biological Membranes — Information and Energy Transduction in 
Biological Membranes. Vienna, 1984, in press. 

Gardner, D. (with White, R.L.), Physostigmine prolongs the elementary event underlying decay 
of inhibitory postsynaptic currents in Aplysu. J. Neurosci. 3 2607-2613, 1983. 



IS 



Gardner, D., Choline blocks inhibitory receptors of Aplysia, revealing a voltage-dependent 
synaptic conductance. Biophys.J. 4 1 : 135a, 1983. 

Grafstein, B. (with Whitehall, M.H.), Changes in perikaryl organelles during axonal regenera- 
tion in goldfish retinal ganglion cells: an analysis of protein synthesis and routing. 
Brain Res. 272:49-56, 1983. 

Grafstein, B., Chromatolysis reconsidered: a new view of the reaction of the nerve cell body to 
axon injury. In: Nerve, Organ and Tissue Regeneration. F.O. Seil, ed. Academic 
Press, New York, 37-50, 1983. 

Heinz, E., (with Grassl, S.M., and Kinne, R.), Effect of K and H on Na-Citrate cotransport in 
renal brush border vesicles. Biochim. Biophys. Acta 736:178-188, 1983. 

Heinz, E., Ion pumps as energy transducers. ACS Symposium Series 207: 323-331, 1983. 

Lee, CO. (with Vassalle, M.), Modulation of intracellular Na + activity and cardiac force by 
norepinephrine and Ca 2+ . Am. J. Physiol. 244:C110-Cll4, 1983. 

Lee, CO. (with Vassale, M.), The relationship among intracellular sodium activity, calcium, 
and strophanthidin inotropy in canine cardiac Purkinje fibers. J. Gen. Physiol. 

83:287-307, 1984. 

Lin, J.T. (with Hahn, K.D.), Synthesis of ( 3 H)phlorizin and its binding behavior to renal brush 
border membranes. Anal. Biochem. 129:337-344, 1983. 

Lin, J.T. (with DaCruz, M.E.M., and Kinne, R.), Temperature dependence of D-glucose trans- 
port in reconstituted liposomes. Biochim. et Biophys. Acta 732:691-698, 1984. 

Maack, T. (with Park, C.H.), Albumin absorption and catabolism by isolated perfused proximal 
tubules of the rabbit. J. Clin. Invest. 73:767-777, 1983. 

Maack, T. (with Camargo, M.J.F., Kleinert, H.D., Atlas, S.A., Sealey,J.E., and Laragh, J.H.), 
Ca-dependent hemodynamic and natriuretic effects of atrial extract in the isolated rat 
kidney. Am. J. Physiol. 246:F447-F456, 1983. 

Nachshen, D.A. (with Drapeau, P.), Manganese fluxes and manganese-dependent neuro- 
transmitter release in presynaptic nerve endings isolated from rat brain. J. Physiol. 

348:493-510, 1984. 

Nachshen, D.A., Selectivity of the Ca binding site in synaptosome Ca channels: Inhibition of 
Ca influx by multivalent metal cations. J. Gen. Physiol. 83:941-967, 1984. 

Palmer, L. G., (with Lorenzen, M.), Antidiuretic hormone-dependent membrane capacitance 
and water permeability in the toad urinary bladder. Am. J. Physiol. 244:F195-F204, 
1983. 

Palmer, L.G. (with Speez, N.), Modulation of ADH-dependent capacitance changes and water 
flow in toad urinary bladder. Am. J. Physiol. 246:F501-F508, 1984. 

Rayson, B.M. (with Nichols, N.R., Khalid, B.A.K., Fuller, P.J., and Funder, J.W.), A com- 
mon 43K protein induced by glucocorticoids in a variety of cells and tissues. 
Submitted to Molecular and Cellular Endocrinology, 1983. 

Rayson, B.M. (with Lowther, S.O.), Steroid regulation of kidney Na + /K + -ATPase: Differential 
sensitivities in the nephron. Am. J. Physiol. 246:F656-F662, 1984. 

Sackin, H. (with Boulpaep, E.L.), Rheogenic transport in the renal proximal tubule. J. Gen. 
Physiol. 82:819-851, 1983. 

Sackin, H. (with Boron, W.F.), Measurement of intracellular ionic composition and activities in 
renal tubules. Ann. Rev. Physiol. 45:483-496, 1983. 

Stephenson, J. L., Renal concentrating mechanism: Fundamental theoretical concepts. FASEB 
Symposium, Fed. Proc. 42:2386-2391, 1983. 



36 



Stephenson, J. L., (with Garner, J. , and Kellogg, B .), Mathematical analysis of a model for the 
renal concentrating mechanism. Mathematical Biosciences 65:125-150, 1983. 



Urban, B.W , (with Haydon, D.A.), The action of alcohols and other nonionic surface active 
substances on the sodium current of the squid giant axon. J. Physiol. 341:411-427, 
1983. 

Urban, B.W. (with Haydon, D A ), The effects of some inhalation anaesthetics on the sodium 
current of the squid giant axon. J. Physiol. 241:429-439, 1983. 

Weinstein, A.M., A non-equilibrium model of the rat proximal tubule epithelium. Biophys. J. 
44:153-170, 1983. 

Weinstein, A.M. (with Windhager, E.E.), Sodium transport along the proximal tubule. In: 
Physiology and Pathology of Electrolyte Metabolism, G. Giebisch, and D. Seldin, 
eds. Raven Press, in press. 

Windhager, E.E. (with Taylor, A.), Regulatory role of intracellular calcium ions in epithelial 
Na transport. Ann. Rev. Physiol. 45:510-532, 1983. 

Windhager, EE. (with Taylor, A., and Lorenzen, M), pH effect on osmotic response of collect- 
ing tubules to vasopressin and 8-CTP-cAMP. Am. J. Physiol. 245:F188-F197, 1983. 




37 



Sloan-Kettering Division 



Unit of Cell Biology and Genetics 

Faculty 

Karen Artzt 
M. Earl Balis 
Dorothea Bennett 
June L. Biedler 
Richard S. Bockman 
Ellen Borenfreund 
Raju S. Chaganti 
Zbigniew Darzynkiewicz 
Eleanor E. Deschner 
David B. Donner 
Magdalena Eisinger 
Jorgen E. Fogh 
Eileen A. Friedman 



Research Activities 

Research in this program encompasses the areas of molecular genetics, cyto- 
genetics, somatic cell genetics and developmental cell biology, including endo- 
crinology. These studies are being pursued using the most modern cellular 
biologic, genetic, molecular biologic and immunologic methodologies. 

Specific study is aimed at understanding cellular and molecular 
mechanisms that control coordinated gene expression and cell proliferation 
during induced cell differentiation, changes in DNA and chromatin structure 
that accompany cell differentiation, and regulatory interactions involved in 
the proliferation and differentiation of normal and neoplastic hematopoietic 
and lymphoid cells. Laboratories in this program are now identifying the 
specific genes and gene products responsible for the control and arrest of cell 
proliferation. This has led to the isolation, characterization and purification 
of growth factors (the interleukins, human granulocyte-macrophage colony- 
stimulating factor, melanocyte growth promoting activity) which may play 
crucial roles in regulating the growth and /or differentiation of cells. 

The regulation of cell growth and function by extracellular agents such 
as peptide hormones, growth factors and neurotransmitters is under investi- 



Paul J. Higgins 
DorrisJ. Hutchison 
lone A. Kourides 
Paul A. Marks 
Myron R. Melamed 
Malcolm A. S. Moore 
Louis M. Pelus 
Richard A. Rifkind 
Allan S. Schneider 
Merry R. Sherman 
Allen E. Silverstone 
Marcello Siniscalco 
Martin Sonenberg 



38 



gation. This involves characterization of: plasma membrane structure and 
function; the relationship between peptide hormone receptor structure and 
transmembrane signalling; structure and regulation of glycoprotein hormone 
gene expression; structure of intracellular receptors for steroid hormones; and 
the properties, functions and hormonal regulation of intracellular peptidase 
activities. 

The genetic control of both normal and abnormal cell differentiation 
during embryogenesis is being characterized by analysis of an extensive set of 
mutations in the T/t complex of the mouse. Mechanisms leading to gene 
amplification and the expression of drug resistance in cultured cells are being 
examined. The role of homogeneously staining regions, double minute 
chromosomes and overproduced gene products in drug resistant cells and as 
related to expression of the malignant neuronal phenotype by human neuro- 
blastoma cells is therefore being investigated. The human genome is being 
mapped. Other research focuses on hereditary factors in the etiology of cancer 
and leukemia in humans as well as the identification of individuals with in- 
herited susceptibility to cancer through understanding mechanisms leading to 
the initiation and progression of neoplasia. In the area of human tumor cell 
biology, the protein products of cellular oncogenes are being identified and 
characterized. The relationship between the expression of these unique gene 
products and cellular transformation is now under intensive investigation. 



Recent Publications 

Artzt. K... Relationship of the murine t-haplotypes and the H-2-complex. , Surv. Immunol. 
Res. 2:278-280, 1983. 

Artzt, K. (with Shin, H-S., Flaherty, L., Bennett, D., and Ravetch.J.), Inversion in the 
H-2-complex of t-haplotypes in mice. Nature, 306:380-383, 1983. 

Balis, M E. (with Dunzendorfer, U., Relyca, N.M., Kleincrt, E., and Whitmore, W.F. Jr.), 
Antigrowth effect of some inhibitors of polyamine synthesis on transplantable prostrate 
cancer. Oncology, 40:57-62, 1983. 

Bennett, D. (with Shin, H-S., McCormick, P., and Artzt, K ), Cis-Trans test shows a functional 
relationship between non-allellic lethal mutations in the T/t -complex. Cell 33:925-929, 
1983. 

Bennett, D. (with Shin, H-S., Flaherty, L., Artzt, K., and Ravetch.J ), Inversion in the H-2 
complex of t-haplotypes in mice. Nature, 306:380-383, 1983. 

Biedlcr, J.L. (with Chang, T-D.. Peterson, R.H.F.. Melcra. P.W., Meyers, M B., and Spcngler, 
B.A.), Gene amplification and phenotypic instability in drug-resistant and revertant 
cells. In: Rational Basis for Chemotherapy. B.A. Chabner, ed. UCLA Symposia on 
Molecular and Cellular Biology. New Series, Vol. 4, New York: Alan R. Liss, Inc., 
pp. 71-92, 1983. 



39 



Biedlcr, J.L. (with Melera, P.W. and Spengler, B.A.), Chromosomes abnormalities and gene 

amplification: Comparison of antifolate-resistant and human neuroblastoma cell systems. 
In: Chromosomes and Cancer: From Molecules to Man. J.D. Rowley andJ.E. Ultmann, 
eds. Bristol-Myers Cancer Symposia, Vol. 5, New York: Academic Press, pp. 117-138, 
1983. 

Bockman, R.S., Prostaglandins in cancer: a review. Cancer Invest. 1:485-493, 1983. 

Bockman, R.S. (with Bellin, A., Repo, M.A., Hickok, N.J., and Kameya, T.), In vivo and 

in vitro biological activities of two human cell lines derived from anaplastic lung cancers. 
Cancer Res. 43:4511-4516, 1983. 

Chaganti, R.S.K., Significance of chromosome changes to hematopietic neoplasms. Blood 
62:515-524, 1983. 

Chaganti, R.S.K. (with Jhanwar, S.C., Koziner B., Arlin, Z. Mertelsmann, R. and Clarkson, 

B. D.), Specific translocations characterize Burkitt's-like lymphoma of homosexual men 
with the acquired immunodeficiency syndrome. Blood 61:1265-1268, 1983. 

Darzynkiewicz, Z. (with Williamson, B., Carswell, E.A., and Old, L.J.), Cell cycle-specific 
effects of tumor necrosis factor. Cancer Res. 44:83-90, 1984. 

Darzynkiewicz, Z. (with Evenson, D., Kapuscinski, J. , and Melamed, M.), Denaturation of 
RNA and DNA in situ induced by Acridine orange. Exp. Cell Res. 148:31-46, 1983. 

Deschner, E.E. (with Alcock, N., Okamura, T., DeCosse, JJ. , and Sherlock, P.), Tissue con- 
centrations and proliferative effects of massive doses of ascorbic acid in the mouse. Nutri- 
tion and Cancer 4:241-246, 1983. 

Deschner, E.E. (with Long, F.C., Hakissian, M., and Cupo, S.H.), Differential susceptibility of 
inbred mouse strains forecast by acute colonic proliferative response to methylazoxy- 
methanol.J. Nat. Cancer Inst. 72:195-198, 1984. 

Donner, D., Covalent coupling of human growth hormone to its receptor on rat hepatocytes. 
J. Biol. Chem. 258:2736-2743, 1983. 

Donner, D. (with Yonkers, K.), Hormone-induced conformational changes in the hepatic 
insulin receptor. J. Biol. Chem. 258:9413-9418, 1983. 

Eisinger, M. (with Marko, O., and Weinstein, I.B.), Stimulation of growth of human melano- 
cytes by tumor promotors. Carcinogenesis 4:779-781, 1983. 

Eisinger, M. (with Tai, T., Ogata, S., and Lloyd, K.O.), Glycoprotein as differentiation mark- 
ers in human malignant melanoma and melanocytes. Cancer Res. 43:2773-2779, 1983. 

Fogh, J.E. (with Drocopoli, N.), Loss of heterozygousity in cultured human tumor cell lines. 
J. Natl. Cancer Inst. 70:83-87, 1983. 

Fogh, J.E. (with Shiu, M.H., Cahan, A., and Fortner, J.G.), Sensitivity of xenografts of human 
pancreatic adenocarcinoma in nude mice to heat and heat combined with chemotherapy. 
Cancer Res. 43:4014-4018, 1983. 

Friedman, E.A., Promotion of human premalignant epithelial cells. In: Human Carcinogenesis. 

C. C. Harris, and H.N. Autrup, eds. New York: Academic Press, pp 325-368, 1983. 

Higgins, PJ. (with Darzynkiewicz, Z., and Melamed, M.R.), Secretion of albumin and alpha- 

foetoprotein by dimethylsulphoxide-stimulated hepatocellular carcinoma cells. Br. J. 

Cancer 48:485-493, 1983. 
Higgins, P.J., Alterations in cellular morphology, proliferation rate and peptide composition 

accompany dimethylsulfoxide-enhanced liver protein synthesis by hepatoma cells. Cell. 

Mol. Biol. 28:299-305, 1983. 

Hutchison, D.J., Modes of acquiring resistance to antineoplastic agents. In: Clinical Chemo- 
therapy. Vol. 3, Antineoplastic Chemotherapy, H.P. Leummerle, ed. New York: 
Thieme-Stratton Inc., pp. 368-383, 1984. 



40 



Hutchison, D.J. (with Schmid, F.A.), Experimental cancer chemotherapy with folate antag- 
onists. In: Folate Antagonists as Therapeutic Agents. Vol. 2, F.M. Sirotnak, J J. Burchall, 
W.B. Ensmiger [sic], and J. A. Montgomery, eds. New York: Academic Press, pp. 1-22, 
1984. 

Kourides, I. A. (with Gurr, J. A., and Catterall, J.F.), Cloning of cDNA encoding the pre-beta 
subunit of mouse thyrotropin. Prox. Natl. Acad. Sci. 80:2122-2126, 1983. 

Kourides, I. A. (with Schorr-Toshav, N.L., Gurr, J. A., and Catterall, J. F.), Thyrotropin and 

alpha-subunit in the brain: evidence for biosynthesis within the pituitary. Endocrinology 
112:1434-1440, 1983. 

Marks, P. A. (with Mutate, T.. Kaneda, T., and Rifkmd, R.A.), Inducer-mcdiated commit- 
ment of murine crythrolcukemia cells to terminal cell division: The expression of com- 
mitment. Proc. Natl. Acad. Sci. 81:3394-3398. 1984. 

Marks, P. A. (with Sheffcry. M., and Rifkind, R.A.), Gene expression in murine erythroleu- 
kemia cells; Transcriptional control and chromatin structure of the ai-globin gene. J. 
Mol. Biol. 172:417-436, 1984. 

Mclamed. M R. (with Klein, F.A.), Flow cytometry of urinary bladder irrigation specimens. 
Human Path. 15:302-305, 1984. 

Melamcd. M R. (with Cordon-Cardo, C, Bander, N.H., Finstad, C.L., Whitmore, W.F., 

Lloyd, K.O., Oettgen, H.F., and Old, L.J.), Immunoanatomic dissection of the human 
urinary tract by monoclonal antibodies. J. Histochem. & Cytochem. 32:1035-1040, 1984. 

Moore, M.A.S. (with Gabrilove, J. , and Sheridan, A. P.), Therapeutic implications of serum 
factors inhibiting proliferation and inducing differentiation of myeloid leukemic cells. 
Blood Cells 9:125-137, 1983. 

Moore. M.A.S. (with Yung, Y-P, and Wang, S-Y), Characterization of mast cell precursors by 
physical means: dissociation from T cells and T cell precursers. J. Immunol. 
130:2843-2848. 1983. 

Pelus, L.M., CFU-GM expression of la-like HLA-DR antigen. An association with the humoral 
control of human granulocyte and macrophage production. Exp. Hematol. 10:219-231. 
1983. 

Pelus, L.M. (with Gold. E., Saletan, S., and Coleman. M ), Restoration of responsiveness of 
of chronic myeloid leukemia granulocyte-macrophage colony -forming cells to growth 
regulation tn vitro following preincubation with prostaglandin E. Blood 62:158-165 
1983. 

Rifkmd, R.A. (with Shen. D.W., Real. F., DeLeo, A., Old. L.J., and Marks. P. A.). Protein 
p53 and inducer-mcdiated erythrolcukcmia cell commitment to terminal cell division. 
Proc. Natl. Acad. Sci. 80:5919-5922, 1983- 

Rifkind, R.A. (with Profous-Juchelka. H.R., Reuben, R.C., and Marks, P. A.), Transcriptional 
and post-transcriptional regulation of globin gene expression in murine erythrolcukcmia 
cells. Mol. and Cell Biol. 3:229-232, 1983. 

Schneider, A.S. (with Herz, R., and Soncnbcrg. M ), Chlortetracycline as a probe of mem- 
brane-associated calcium and magnesium: interaction with red cell membranes, 
phospholipids, and proteins monitored by fluorescence and circular dichroism. Biochem. 
22:1680-1686, 1983. 

Sherman. M R. (with Moran, M.C., Tuazon, F.B.. and Stevens, Y.-W ), Structure, dissocia- 
tion, and proteolysis of mammalian steroid receptors. Multiplicity of glucocoticoid recep- 
tor forms and proteolytic enzymes in rat liver and kidney cytosols. J. Biol. Chcm. 
258:10366-10377. 1983. 



41 



Sherman, M.R. (with Tuazon, F.B., Stevens, Y.-W., and Niu, E.-M.), Oligomeric steroid re- 
ceptor forms and their dissociation and proteolysis. In: Steroid Hormone Receptors: 
Structure and Function. Proceedings of the 57th Nobel Symposium, Karlskoga, Sweden, 
1983, Eriksson, H. and Gustafsson, J.-A. , eds. Amsterdam, Elsevier, 3-24, 1983. 

Silverstone, A.E. (with Dorner, M.H., De Sostoa, A., Munn, G., and De Sousa, M.), Relative 
subunit composition of the ferritin synthesized by selected human lymphomyeloid cell 
populations. Exp. Hematol. 11:866-872, 1983. 

Siniscalco, M. (with Filippi, G., Mannucci, P.M., Coppola. R., Farris, A., and Rinaldi, A.), 

Studies on hemophilia A in Sardinia bearing on the problems of multiple allelism, carrier 
detection, and differential mutation rate in the two sexes. Am. J. Hum. Genet. 
36:44-71, 1984. 

Sinsiscalco, M. (with Szabo, P., and Grzeschik, K.-H.), A human autosomal phosphoglycerate 
kinase locus maps near the HLA cluster. Proc. Natl. Acad. Sci. 81:3167-3169, 1984. 

Sonenberg, M. (with Friedhoff, L.T.), The membrane potential of human platelets. Blood 
61:180-185, 1983. 

Sonenberg, M. (with Corin, R.E., and Haspel, H.C.), Transport of the folate compound 

methotrexate decreases during differentiation of murine erythroleukemia cells. J. Biol. 
Chem. 259:206-211, 1984. 



Unit of Developmental Therapy and Clinical Investigation 

Faculty 

Nancy W. Alcock 
Lowell L. Anderson 
Ting-Chao Chou 
Martin Fleisher 
Jerrold Fried 
Jack J. Fox 
Allan S. Gelbard 
Nancy L. Geller 
Susan Groshen 
Raymond W. Houde 
Jae Ho Kim 
John S. Laughlin 



Research Activities 

The metabolism of normal and cancerous tissue in situ is being studied. This 
research program includes the innovative operation of the first isochronous 



Bipin M. Mehta 
Jerome S. Nisselbaum 
Brian A. Otter 
Joseph Roberts 
Morton K. Schwartz 
Francis M. Sirotnak 
Stephen S. Sternberg 
Howard T. Thaler 
Kyoichi Watanabe 
George Y. Wong 
Louis Zeitz 



42 



cyclotron to be used in a medical research institution, resulting in the capaci- 
ty to visualize tumors as well as specific organs and tissues. 

Studies of the pharmacology and pharmacokinetics of analgesic drugs in 
animal models and cancer patients are being carried out to provide a rational 
basis for the management of pain due to cancer. Pilot studies have begun on 
the role of serotonin in cancer associated anorexia. 

Development of more selective therapeutic strategies based on differ- 
ences in membrane transport and metabolic activation or inactivation of new 
agents versus normal proliferative cells continues to be the major focus of 
other research studies. Methods are also under study for chemical modifica- 
tion of antitumor enzymes to increase biological half-life, abolish immuno- 
genicity, and alter tissue specificity. The effects of selected cytotoxic drugs 
and regulators of cell growth on differentiation of normal and neoplastic 
human hematopoietic cells are being explored. 

Studies are also being carried out to determine whether or not various 
tumor promotors could affect the expression of previously identified cell sur- 
face antigens on normal human melanocytes or melanoma cells. Satisfactory 
procedures have been developed for autologous transplantation of frozen and 
stored hematopoietic stem cells. Also under investigation are improved 
methods for purging marrow of residual tumor cells and the phenotypic 
characterization of human leukemias and lymphomas. 

Investigators have been working with flow cytometry to detect cell sur- 
face membrane light chain expression in minimal numbers of B-lymphocytes. 
This technique, which is called clonal excess and requires a mathematical 
calculation, allows the detection of less than 5 percent of malignant cells in 
cell suspension. 

Other research objectives of this Unit are to characterize the effects of 
various substances on the proliferation, differentiation, and identification of 
biochemical substances produced by selected childhood tumors and skin tumor 
tissue fibroblasts. 

Additional projects include the mode of action of antitumor and antiviral 
agents, the toxic actions of these agents in normal host tissues and mechanisms 
of acquired resistance of tumors and viruses to these agents. The latter studies 
also focus on the phenomenon of polydrug resistance. Preclinical and clinical 
evaluation of new analgesic, anticancer and antiviral drugs in terms of their 
distribution, metabolism and pharmacologic behavior are also being under- 
taken. These findings are correlated with observed toxic and therapeutic ef- 
fects in controlled trials incorporating novel biostatistic approaches. 

There are studies which seek to identify plciotypic tumor-associated bio- 
chemical properties which might be exploited for greater antitumor selectivity. 
Some properties already identified as tumor-specific include certain nutrient 
transport mechanisms which mediate accumulation of cytotoxic drugs and 
DNA repair deficiencies. 



43 



Recent Publications 



Alcock, N.W. (with Casper, E.S., Kelsen, D.P., and Lewis, J. L., Jr.), Ip cisplatin in patients 
with malignant ascites: pharmacokinetic evaluation and comparison with the iv route. 
J. Cancer Treat. Rep. 67:235-238, 1983. 

Anderson, L.L., Remote afterloading in cancer management, Part 1: After-loader design and 
optimization potential. In: Brachytherapy Oncology-1983. B.S. Hilaris, and M.A. 
Batata, eds. New York: Memorial Sloan-Kettering Cancer Center, pp. 93-100, 1983. 

Anderson, L.L., Brachytherapy dose calculations. In: Computerized Treatment Planning 

Systems. RJ. Morton, and F. Bagne, eds. HHS Publication FDA 84-8223, Rockville, 
MD: Bureau of Radiological Health, U.S. Department of Health and Human Services, 
pp. 150-156, 1984. 

Chou, T.-C. (with Schmid, F.A., Feinberg, A., Phillips, F.S., and Han, J.), Uptake, initial 

effects, and chemotherapeutic efficacy of harringtonine in murine leukemic cells sensi- 
tive and resistant to vincristine and other chemotherapeutic agents. Cancer Res. 
43:3074-3079, 1983. 

Fleisher, M. (with Bradlow, H.L., Schwartz, M.K., Rosenfeld, R.S., Kream,J., Schwartz, D., 
Breed, C.N., and Fracchia, A. A.), Hormone levels in human breast cyst fluid. In: 
Endocrinology of Cystic Breast Disease. A. Angeli, H.L. Bradlow, and L. Dogliotti, eds. 
New York: Raven Press, pp. 59-75, 1983. 

Fleisher, M. (with Bradlow, H.L., Skidmore, F.D., Schwartz, M.K., and Schwartz, D.), 

Cations in breast cyst fluid. In: Endocrinology of Cystic Breast Disease. A. Angeli, H.L. 
Bradlow, and L. Dogliotti, eds. New York: Raven Press, pp. 197-201, 1983. 

Fried, J. (with Perez, A.G., Doblin, J.M., and Clarkson, B.D.), Factors modifying the syner- 
gistic toxicity of deoxycytidine in combination with thymidine plus 5-fluorouracil in 
HeLa cells. Cell Tissue Kinet. 16:539-548, 1983. 

Fox, J.J. (with Young, C.W., Schneidet, R., Leyland-Jones, B., Armstrong, D., Tan, C.T.C., 
Lopez, C, Watanabe, K.A., and Philips, F.S.), Phase 1 evaluation of 2 '-fluoro-5-iodo- 
1-beta-D-atabinofuranosylcytosine in immunosuppressed patients with herpesvirus in- 
fection. Cancer Res. 43:5006-5009, 1983. 

Fox, J.J. (with Pankiewicz, K.W., Matsuda, A., and Watanabe, K.A.), Nucleosides-126. 

Selective methylation of the C-nucleoside, psi-isocytidine and its 2 '-deoxy analog. Syn- 
thesis of 1-methyl, 3-methyl and 4-0-methyl derivatives. Tetrahedron 40:33-38, 1983. 

Geller, N.L. (with Bosl, G.J., Carrincione, C, Vogelzang, N.J., Kennedy, B.J., Whitmore, 
W.F., Jr., Vugrin, D., Scher, H., Nisselbaum, J. , and Golbey R.B.), Multivariate 
analysis of prognostic variables in patients with metastatic testicular cancer. Cancer Res. 
43:3403-3407, 1983. 

Geller, N.L. Statistical strategies for animal conservation. Ann. N.Y. Acad. Sci. 406:20-31, 
1983. 

Groshen, S. (with Dinsmore, R., Kirkpatrick, D., Flomenberg, N., Gulati, S., Kapoor, N., 
Shank, B., Reid, A., and O'Reilly, RJ ), Allogeneic bone marrow transplantation for 
patients with acute lymphoblastic leukemia. Blood 62:381-388, 1983. 

Groshen, S. (with Li, W.K., Lane, J. M., Rosen, G., Marcove, R.C., Caparros, B., and 
Huvos, A.), Pelvic Ewing's sarcoma. Advances in treatment. J. Bone Joint Surg. 

65A:738-747, 1983. 

Houde, R.W. (with Grabinski, P.Y., Kaiko, R.F., Walsh, T.D., and Foley, K.M.), Morphine • 
radioimmunoassay specificity before and after extraction of plasma and cerebrospinal 
fluid. J. Pharm. Sci. 72:27-30, 1983. 



44 



Houdc, R.W. (with Kaiko, R.F., Wallcnstcin, S.I., and Rogers, A.G.), Sources of variation in 
analgesic responses in cancer patients with chronic pain receiving morphine. Pain 
15:191-200, 1983. 

Kim, J.H (with Leepcr, R.D.), Treatment of anaplastic giant and spindle cell carcinoma of the 
thyroid gland with combination adriamycin and radiation therapy. A new approach. 
Cancer 52:954-957, 1983. 

Kim, J.H (with Kim, S.H., and He, S ), Modification of thermosensitivity of Hela cells by 
sodium butyrate, dibutyryl cyclic adenosine 3 :5 -monophosphate, and retinoic acid. 
Cancer Res. 44:697-702, 1984. 

Laughlin, J.S. (with Nath, R., Epp, E.P., Swanson, W.P., and Bond, V P ), Neutrons high 
energy X-ray medical accelerators: An estimate of risk to the radiotherapy patient. 
Medical Physics 11:231-241, 1984. 

Laughlin. J.S. , Development of quality assurance in radiation therapy in North America. Int . J. 
Radiation Oncology Biol. Phys. 10: No. 1, 1984. 

Mehta. B.M. (with Glass, J. P., and Shapiro, W.R.), Serum and cerebrospinal fluid distribution 
of 5-methyltetrahydrofolate after intravenous calcium leucovorin and intra-Ommaya 
methotrexate administration in patients with meningeal carcinomatosis. Cancer Res. 
43:435-438, 1983. 

Nissclbaum, J.S. (with Bosl, G.J., Geller, N.L., Cirrincione, C, Vurgin, D., Whitmore, E.F.Jr., 
and Golbey, R.B.), Serum tumor markers in patients with metastatic germ cell tumors 
of the testis: A 10-year experience. J. Am. Med. 75:29-35, 1983. 

Otter, B.A. (with Lim, M-I., Ren, W-Y., and Klein, R.S.), Synthesis of "9-deazaguanosine" 
and other new pyrrolo[3,2-d] pyrimidine C-nucleosides. J. Org. Chem. 48:780-788, 
1983. 

Otter, B.A. (with Sasson, I., and Gagnier, R.P.), The chemistry of 5-hydroxy-6- (hydroxyalkyl) 
uracils. Synthesis of spiro[pyrimidinc-4,2 '-pyrano[3,2-d] pyrimidines] J. Heterocyclic 
Chem. 20:753-757, 1983. 

Roberts, J. (with Ammon, H.. Murphy, K., Sjolin, L., Wlodawer, A., and Holcenberg, J.), The 
molecular symmetry of glutaminase-asparaginases: Rotation function studies of the 
Pseudomonas 7 A and Aanetobacter enzymes. Acta. Crystallogr. B39:250-257, 1983. 

Roberts, J. (with Steckel, J., Philips. F.S., and Chou, T.C.), Kinetic properties and inhibition 
of Aanetobacter glutaminase-asparaginase. Biochem. Pharmacol. 32:971-977, 1983 . 

Schwartz, M.K. (with Osborne, M P., Rosen, P.P., Lesser, M L., Menendez-Botet, C.J., 

Fishman. J.H. . Kinne, D.W . and Beattie, E.J . , Jr.) , The relationship between family 
history, exposure to exogenous hormones, and estrogen receptor protein in breast 
cancer. Cancer 51:2134-2138, 1983. 

Schwartz, M.K., Immunoassay of enzymes — an overview. Clin. Biochem. 16:4-9, 1983. 

Sirotnak, F.M. (with Dembo, M., and Moccio, D M ), Effects of metabolic deprivation on 

methotrexate transport in LI 2 10 leukemia cells: Further evidence for separate influx and 
efflux systems with different energetic requirements. J. Membrane Biol. 78:9-17, 1983. 

Sirotnak, F.M. (with Chello, PL., Dorick, DM., and Montgomery , J. A.), Specificity of systems 
mediating transport of adenosine, 9-B-D-arabinofuranosyl-2-fluoroadenine, and other 
purine nucleoside analogues in L1210 cells. Cancer Res. 43:104-109, 1983. 

Sternberg, S.S. (with Morrow, R., Wong, B.. Finkelstein, W.E., and Armstrong, D ), 

Aspergillosis of the cerebral ventricles in a heroin abuser: case report and review of the 
literature. Arch. Intern. Med. 143:161-164, 1983. 

Sternberg, S.S. (with Witt, T.R., and Shah, J. P.), Juvenile nasopharyngeal angiofibroma. A 30 
year clinical review. J. Am. Surg. 146:521-525, 1983- 



45 



Thaler, H.T. (with Lu, L., Broxmcyer, H.E., Meyers, P. A., and Moore, M.A.S.), Association 

of cell cycle expression of la-Like antigenic determinants on normal human multipoten- 
tial (CFU-GEMM) and erythroid (BFU-E) progenitor cells with regulation in vitro by 
acidic isoferritins. Blood 61:250-256, 1983. 

Thaler, H.T. (with Straus, D.J., Filippa, D.A., Lieberman, P.H., Koziner, B., and Clarkson, 
B.D.), The non-Hodgkin's lymphomas. 1. A retrospective clinical and pathologic 
analysis of 499 cases diagnosed between 1958 and 1969. Cancer 51:101-109, 1983. 

Watanabe, K.A. (with Su, T.L., Pankiewicz, K.W., and Harada, K.), Novel ring transforma- 
tion reactions and their applications to the syntheses of potential anticancer heterocyclic 
compounds. Heterocycles 21:289-307, 1984. 

Watanabe, K.A. (with Su, T-L., Reichman, U., Greenberg, N., Lopez, C, and Fox, J.J. ), 
Nucleosides. 129. Synthesis of antiviral nucleosides: 5-Alkenyl-l-(2-deoxy-2-fluoro- 
B-D-arabinofuranosyl) uracils. J. Med. Chem. 27:91-94, 1984. 

Wong, G.Y., Rank-one round robin designs. J. American Stat. Assn. 79:136-144, 1984. 

Zeitz, L. (with Laughlin, J.S. , Ma, I., and Pipman, J.), "Non-isolated-sensor" solid tissue 
equivalent A-150 plastic absorbed dose measurements. Radiation Res. 94:578, 1984. 



Unit of Immunobiology 

Faculty 

Edward A. Boyse 

Yvon Cayre 

Yong Sung Choi 

Charlotte Cunningham-Rundles 

Bo Dupont 

Robert L. Evans 

Ulrich Hammerling 

Michael K. Hoffmann 

Genevieve S. Incefy 

Gloria C. Koo 

Janet Lee 

Gary W. Litman 



Kenneth O. Lloyd 
Carlos Lopez 
Herbert F. Oettgen 
Lloyd J. Old 
Richard J. O'Reilly 
Chris D. Platsoucas 
Bijan Safai 
Margrit P. Scheid 
Fung-Win Shen 
Osias Stutman 
Jwu-Shen Tung 



Research Activities 

This program comprises the development, general properties, function and 
regulation of the cellular components of the immune response, as well as of 
the secreted products of such cells. The program's research is in three main 



46 



areas: 1) immunogenctics, especially the cell surface determinants involved in 
the differentiation and function of normal and malignant lymphoid cells; 

2) cellular immunology and immunoregulation, especially the cellular interac- 
tions and soluble factors that are required for effective immune responses; 

3) tumor immunology, particularly the analysis of the immunological proper- 
ties of the transformed cancer cells and the interactions between tumor and 
host, aimed at designing possible diagnostic or therapeutic strategies. Re- 
search in these three main areas is done both using experimental models as 
well as human cells. In vitro technology in particular has allowed the con- 
tinuous growth and cloning of most of the relevant lymphoid cells and the 
testing of their immunological functions. Some research projects, such as 
bone marrow transplantation for the correction of immunological and hema- 
tological abnormalities or the treatment of lympho-hcmopoietic malignancies 
in patients bridge the three main areas of research, both at the clinical level 
and with the animal models. Since immunology is multidisciplinary in its ap- 
proaches to a given problem, it not only has generated its own technology 
(such as the production of monoclonal antibodies) but uses the methods of 
other disciplines, such as biochemistry, for the isolation of a given membrane 
surface antigen, and molecular biology for the characterization of the gene(s) 
coding for such a determinant (and its own in vitro technology for the assess- 
ment of the function of such a determinant). The main aims of the research 
in the program are to define immunological events at the biological, struc- 
tural, biochemical and molecular level. 

The Unit offers the opportunity for obtaining a Ph.D. degree with em- 
phasis on various sub-diciplines of immunology such as immunochemistry, 
immunogenetics, immunopathology, serology, transplantation immunology, 
tumor immunology, and clinical immunology. 



Recent Publications 

Boysc, E.A. (with Beauchamp, G.K., and Yamazaki, K ), The sensory perception of genotypic 
polymorphism of the major histocompatibility complex and other genes: some 
physiological and phylogenetic implications. Human. Immunol. 6:177-183, 1983. 

Boyse, E.A. (with Yamazaki. K., Beauchamp, G.K.. Egorov, I.K., Bard, J., and Thomas, L.), 
Sensory distinction between H-2 h and H-2 hml mutant mice. Proc. Natl. Acad. Sci. 
80:5685-5688. 1983. 

Cayre. Y. (with Daniel, F., Morello, D., Le Bail, O., Chambron, P., and Kourilsky, P.), 

Structure and expression of the mouse ^2-microglobulin gene isolated from somatic and 
non-expressing teratocarcinoma cells. EMBOJournal 2:1061-1065, 1983. 

Choi, Y.S. (with Wrigley, D M ). Characterization of the subpopulations of human peripheral 
blood B lymphocytes which react to Staphylococcus aureus Cowan I and T-cell help. 
Cell. Immunol. 78:130-143. 1983. 



47 



Choi, Y.S. (with Lee, M.S., and Rosenspire, AJ.), A novel method to radio-iodinate antigen- 
binding receptors of B lymphocytes. Molec. Immunol. 30:1249-1257, 1983. 

Cunningham-Rundles, C. (with Carr, R.I.), Dietary protein anti-genemia in humoral immuno- 
deficiency disease: correlation with splenomegaly. Am. J. Med. 70:181-185, 1984. 

Dupont, B. (with Flomenberg, N., Kazuyuki, N., Duffy, E., Knowles, R.W., and Evans, R.L.), 
Allocytotoxic T cell clones: Both Leu 2 + 3- and Leu 2-3 + T cells recognize class I histo- 
compatibility antigens. Eur. Jr. Immunol. 13:905-911, 1983. 

Dupont, B. (with Broxmeyer, H.E., Juliano, L., Lu, L., and Platzer, E.), HLA-DR human 

histocompatibility leukocyte antigens-restricted lymphocyte-monocyte interactions in the 
release from monocytes of acidic isoferritins that suppress hematopoietic progenitor cells. 
J. Clin. Invest. 73:939-953, 1984. 

Evans, R.L. (with Engelman, E.G., Benike, C.J., Metzler, C, and Gatenby, P. A.), Blocking of 
human T lymphocytes functions by anti-leu-2 and anti-leu-3 antibodies: differential in- 
hibition of proliferation and suppression. J. Immunol. 130:2623-2628, 1983. 

Evans, R.L. (with Rinnooy, K.E., Wang, C.Y., and Wang, L.C.), Noncovalently bonded sub- 
units of 22 and 28 kd are rapidly interalized by T cells reacted with anti-leu-4 antibody. 
J. Immunol. 131:536-539, 1983. 

Hammerling, U. (with Chan, M.M., Tada, N., Kimura, S., Hoffmann, M.K., Miller, R.A., 

and Stutman, O.), Characterization of T lymphocyte subsets with monclonal antibodies: 
discovery of a distinct marker, Ly-m22, of T suppressor cells. J. Immunol. 

130:2075-2078, 1983. 

Hammerling, U. (with Tada, N., Kimura, S., and Liu-Lam, Y.), Exchange of cell-associated 
beta 2 -microglobulin in mouse chimeras. Immunogenetics 18:173-175, 1983. 

Hoffmann, M.D. (with Chan, M M., Tada, N., Kimura, S., Miller, R.A., Stutman, O., and 

Hammerling, U.), Characterization of T lymphocyte subsets with monoclonal antibodies: 
discovery of a distinct marker, Ly-m22, of T suppressor cells. J. Immunol. 

130:2075-2078, 1983. 

Hoffmann, M.K. (with Gilbert, K.M.), Supressor B lymphocytes. Immunol. Today 4:253-255, 
1983. 

Incefy, G.S., Effect of thymic hormones on human lymphocytes. Clin. Immunol. Allergy 

3:95-117, 1983. 

Incefy, G.S. (with Yamanaka, R., and Good, R.A.), Functional maturation difference between 
splenocytes that form autologous rosettes in adult thymectomized and aged mice. 
Thymus 5:35-42, 1983. 

Koo, G.C. (with Reidy, J.A., Hammerling, U., and Cederqvist, L.L.), Fetal H-Y typing using 
human amniotic fluid. Am. J. Reprod. Immunol. 3:59-60, 1983. 

Koo, G.C. (with Reidy, J. A., and Nagamine, CM.), H-Y antigen in XO mice. Immuno- 
genetics 18:37-44, 1983. 

Litman, G.W. (with Berger, L., Murphy, K., Litman, R., Hinds, K., Jahn, C.L., and Erickson, 

B. W.), Complete nucleotide sequence of an immunoglobin in VH gene homoloque 
from Caiman, a phylogenetically ancient reptile. Nature 303:349-352, 1983. 

Litman, G.W., Phylogeny of immunoglobulins. In: Molecular Immunonology. M.Z. Atassi, 

C. J. Van Oss, and D.R. Absolum, eds. New York: Marcel Dekker, pp. 215-230, 1983. 

Lloyd, K.O. (with Larson, G., Stromberg, N., Thruin, J., and Karlsson, K.-A.), Mouse mono- 
clonal antibody F-3 recognizes the difucosyl type-2 blood group structure. Immuno- 
genetics 17:537-541, 1983. 



48 



Lloyd, K.O. (with Fradct. Y., Cordon-Cardo, C, Thomson, T., Daly, M.E., Whitmorc, W.F., 
Mclamed. MR, and Old, L.J.), Cell surface antigens of human bladder cancer defined 
by mouse monoclonal antibodies. Proc. Natl. Acad. Sci. 81:224-228, 1984. 

Lopez, C. (with Colacino, J.M.), Efficacy and selectivity of some nucleoside analogs as anti- 
human cytomegalovirus agents. Antimicrob. Agents Chemother. 24:505-508, 1983. 

Lopez, C. (with Fitzgerald, P. A., and Sicgal F.P.), Severe acquired immune deficiency syn- 
drome in male homosexuals: diminished capacity to make intcrferon-alpha in vitro 
associated with severe opportunistic infections. J. Infect. Dis. 148:962-966, 1983. 

Oettgen, H.F. (with Houghton, A.N., Brooks, H., Cote, R.J., Taormina, M.C., and Old, L.J.), 
Detection of cell surface and intracellular antigens by human monoclonal antibodies. 
Hybrid lines derived from lymphocytes of patients with malignant melanoma. J. Exp. 
Med. 158:53-65, 1983. 

Oettgen, H.F. (with Knuth, A., Danowski, B., and Old, L.J.), T-cell mediated cytocoxicity 
against autologous malignant melanoma: Analysis with interleukin 2-dcpcndent T-cell 
cultures. Proc. Natl. Acad. Sci. 81:3511-3515, 1984. 

Old. L.J. (with Albino, A. P., Lloyd, K.O.. and Ikeda, H.). Biochemical analysis of a 130,000 
molecular weight glycoprotein on human melanoma cells. J. Immunol. 131:1595-1599, 
1983. 

Old, L.J. (with Fradet, Y., Cordon-Cardo, C, Thomson, T., Daly M.E., Whitmore, W.F., Jr., 
Lloyd, K.O., and Mclamed, M R ), Cell surface antigens of human bladder cancer de- 
fined by mouse monoclonal antibodies. Proc. Natl. Acad. Sci. 81:224-228, 1984. 

O'Reilly, R.J., Allogeneic bone marrow transplantation: Current status and future directions. 
Blood 62:941-964, 1983. 

O'Reilly, R.J. (with Kapoor, N., Kirkpatrick, D., Cunningham-Rundles, S., Pollack, M.S., 
Dupont, B., Hodes, M.Z., Good, R.A., and Reisner, Y ), Transplantation for severe 
combined immunodeficiency using histocompatiblc parental marrow fractionated by soy- 
bean agglutination and sheep red blood cells: experience in six consecutive cases. 
Transplant Proc. 15:1405-1411, 1983. 

Platsoucas, CD., Immunomodulation of human lymphocytes by E. colt- derived human 

gamma interferon. In: The Biology of the Interferon System 1983. E. De Maeyer, and 
H. Schellekens, eds. Amsterdam: Elsevier, pp. 305-310, 1983. 

Platsoucas, CD. (with Hansen, H.J.. Redman, J. R., Bercnson, S., Lee, B.J. Ill, and Clarkson, 
B.D.), T-cell imbalances in patients with multiple myeloma: an analysis 11 by mono- 
clonal antibodies. J. Clin. Immunol. 3:277-284, 1983. 

Safai, B. (with Coibanu, N., Welte, K., Kruger, G., Vcnuta., Gold, J., Feldman, S.P., 
Wang, C.Y.. Koziner, B., Moore, M A S., and Mertelsmann, R ), Defective T-cell 
response to PHA and mitogenic monoclonal-antibodies in male homosexuals with ac- 
quired immunodeficiency syndrome and its in vitro correction by intcrlcukin-2. J. Clin. 
Immunol. 3:332-340, 1983. 

Safai, B. (with Myskowski. P L., Dupont, B., and Pollack, M.S.), Association of HLA-DR5 with 
mycosis fungoides. J. Invest Dermatol. 80:395-397, 1983. 

Scheid, M P (with Landreth, K.S., Tung, J. S., and Kincade. P.W.), Preferential but non- 
exclusive expression of macromolecular antigens on B-lincage cells. Immunol Rev. 
69:141-159, 1983. 

Scheid, M P. (with Tung, J.S. , and Palladino, M. A ), Different forms of Ly-5 within the cell 
lineage Immunogcnet. 17:649-654, 1983. 



49 



Shen, F.-W. (with Michaelson, J., Boyse, E.A., Chorney, M., Flaherty, L., Fleissner, 

Hammerling, U., Reinisch, C, and Rosenson, R.), The biochemical genetics of the Oa- 
Tla region. Transplant Proc. 15:2033-2038, 1983. 

Shen, F.-W. (with Yakura, H., Bourcet, E., and Boyse, E.A.), On the function of Ly-5 in the 
regulation of antigen-driven B cell differentiation. J. Exp. Med. 157:1077-1088, 1983. 

Stutman, O. (with Miller, R.A.), Limiting dilution analysis of T helper cell heterogeneity: a 
single class of T cell makes both IL-2 and IL-3.J. Immunol. 130:1749-1753, 1983. 

Stutman, O. (with Carnaud, C, and Ishizaka, S.T.), Early loss of precursors of CTL and IL-2 
producing cells in the development of neonatal tolerance to alloantigens. J. Immunol. 

133:45-51, 1984. 

Tung, J. -S. (with Scheid, M.P., and Palladino, M.A.). Different forms of Ly-5 within the T-cell 
lineage. Immunogenet. 17:649-654, 1983. 



Unit of Molecular Biology and Virology 

Faculty 

F. Carter Bancroft 
Licbe F. Cavalieri 
Sclina Y. Chen-Kiang 
Nancy G. Famulari 
Erwin Fleissner 
Mark E. Furth 
Sohan Lai Gupta 
William W. Hardy Jr. 
William S. Hayward 
Jerard Hurwitz 
Robert M. Krug 
Elizabeth Lacy 
Kenneth J. Marians 
Peter W. Melera 



Research Activities 

The major areas of research training in this Unit are in cellular and viral gene 
expression, DNA replication, control mechanisms in cellular metabolism and 
growth, and the molecular basis of oncogenesis. Investigators utilize modern 
biochemical and molecular genetic methods in experimental systems ranging 



Mukund J. Modak 
Norma Neff 
Paul V. O'Donnell 
Allen I. Oliff 
Abraham Pinter 
Jeffrey V. Ravetch 
Ora M. Rosen 
Barbara H. Rosenberg 
Nural H. Sarkar 
Ganes C. Sen 
Michael Sheffery 
Edward Stavnezer 
Janet Stavnezer 



50 



from prokaryotes and simple eukaryotes to transgenic mice and human tumor 
cells. 

The control of gene expression is studied in a variety of viral and cellular 
systems, in vitro, in cell culture, and in the intact organism. Influenza virus 
and adenovirus serve as models for the control mechanisms involved in the 
synthesis, processing and translation of RNA, both in the cell and in cell-free 
systems. Various eukaryotic virus expression vectors are being constructed for 
these studies. Virus-infected cells are also being employed for molecular 
studies of interferon action. Cells responsive to specific inducing agents are 
used to elucidate the regulation of gene transcription by peptide hormones, 
by interferon, and by chromatin structure. The gene amplification or rear- 
rangement events frequently observed in tumor cells reveal the profound 
effects of such DNA alterations on gene transcription. Mice carrying new 
genes introduced by injection of DNA into early embryos provide novel ex- 
amples of tissue-specific control of gene expression. 

Research on the mechanism of both prokaryotic and eukaryotic DNA 
replication employs cell-free replication systems. Cell-free synthesis of adeno- 
virus DNA is being employed as the model system to elucidate control 
elements and specific protein-nucleic acid interactions involved in eukaryotic 
DNA replication. 

Much of the research on the control of cellular metabolism and growth 
focuses on crucial regulatory proteins involved in the transmission of signals 
at the cell membrane, including various cell surface receptors, protein 
kinases, and the calcium binding protein calmodulin. In addition to 
biochemical and physiological studies, substantial effort is being made to 
isolate and determine the nucleotide sequences of the genes encoding these 
important proteins. 

A large area of research centers on viral and cellular genes directly im- 
plicated in neoplasia. Studies have shown that retroviruses in birds, rodents, 
and cats transduce a number of oncogenes encoding proteins that vary greatly 
in their cellular localization, biochemical function, and mechanism of activa- 
tion. Other retroviruses do not carry oncogenes, but alter the expression of 
cellular oncogenes, leading to the development of specific cancers, such as 
lymphomas, thymomas and erythroleukemia. Activated oncogenes have also 
been identified in the DNA of animal and human tumors with no known 
viral etiology. The study of the mechanism of activation of these cellular 
genes and of their gene products may provide insight into the molecular basis 
of human cancer. 



51 



Recent Publications 



Bancroft, F.C. (with Gick, G.G., Zcytin, F.N., Brazeau, P., Ling, N.C., and Esch, F.S.), 
Growth hormone-releasing factor regulates growth hormone mRNA in primary 
cultures of rat pituitary cells. Proc. Natl. Acad. Sci. 81:1553-1555, 1984. 

Bancroft, F.C. (with Gerhard, D.S., Szabo, P., and Kawasaki, E.), The prolactin gene, but 
not the growth hormone gene, is located on chromosome 9 in the rat. DNA 
3:139-145, 1984. 

Besmer, P. (with Hardy, W.D.Jr., Zuckerman, E.E., Bergold, P., Lederman, L., and Snyder, 
H.W. Jr.), The Hardy-Zuckerman 2-FeSV, a new feline retrovirus with oncogne 
homology to Abelson-MuLV. Nature 303:825-828, 1983. 

Besmer, P. (with Snyder, H.W. Jr., Murphy, J. E., Hardy, W.D.Jr., and Parodi A.), The 
Parodi-Irgens feline sarcoma virus and simian sarcoma virus have homologous on- 
cogenes, but in different contexts of the viral genomes. J. Virol. 46:606-613, 1983. 

Chen-Kiang, S. (with Maderious, A.), Pausing and premature termination of human RNA 

polymerase II during transaction of adenovirus in vivo and in vitro. Proc. Natl. Acad. 
Sci. 1984, in press. 

Chen-Kiang, S. (with Mok, M., and Maderious, A.) Premature termination by human RNA 
polymerease II occurs temporally in the adenovirus major late transcriptional unit. 
Mol. Cell. Biol. 1984, in press. 

Famulari, N.G. (with Cieplensky, D.), A time-course study of MuLV env gene expression in the 
AKR thymus: qualitative and quantitative analysis of ecotropic and recombinant virus 
gene products. Virology 132:282-291, 1984. 

Famulari, N.G., Murine leukemia viruses with recombinant env genes: A discussion of their 
role in leukemogenesis. J. Cur. Top. in Microbio. and Immu. 130:75-108, 1983. 

Fleissner, E. (with Boccara, M., Souyri, M., Magarian, C, and Stavnezer, E.), Evidence for 

a new form of retroviral env transcript in leukemic and normal mouse lymphoid cells. 
J. Virol. 48:102-109, 1983. 

Fleissner, E. (with Souyri, M.), Identification by transfection of transforming sequences in DNA 
of human T-cell leukemias. Proc. Natl. Acad. Sci. 80:6676-6679, 1983. 

Furth, M. (with Fasano, O, Aldrich, T., Tamanoi, F., Taparowsky, E., and Wigler, M.), 

Analysis of the transforming potential of the human H-ras gene by random muta- 
genesis. Proc. Natl. Acad. Sci. 81:4008-4012, 1984. 

Gupta, S.L. (with Raziuddin, A., and Sarkar, F.H.), Interferon receptors on human cells. 

In: The Biology of the Interferon System. E. DeMaeyer, and H. Schellekens, eds. 
Amsterdam: Elsevier, pp. 175-181, 1983. 

Hardy, W.D.Jr., A new package for an old oncogene. Nature 308:775, 1984. 

Hardy, W.D.Jr. (with Besmer, P., Zuckerman, E.E., Bergold, P., Lederman, L., and Snyder, 
H.W. Jr.), The Hardy Zuckerman 2-FeSV, a new feline retrovirus with oncogene 
homology to Abelson-MuLV. Nature 303:825-828, 1983. 

Hayward, W.S. (with Jhanwar, S.C., Neel, B.G., and Chaganti, R.S.K.), Localization of c-ras 
oncogene family on human germ-line chromosomes. Proc. Natl. Acad. Sci. 
80:4794-4797, 1983. 

Hayward, W.S. (with Saito, H., Hayday, A.C., Wiman, K., and Tonegawa, S.), Activation 
of the c-myc gene by translocation: a model for translocational control. Proc. Natl. 
Acad. Sci. 80:7476-7480, 1983. 



52 



Hurwitz, J. (with Nagata, K., and Guggenheimer, R.A.), Specific binding of a cellular DNA 
replication protein to the origin of replication of adenovirus DNA. Proc. Natl. Acad. 
Sci. 80:6177-6181, 1983. 

Hurwitz, J. (with Guggenheimer, R.A., Stillman, B.W., Nagata, K., and Tamanoi, F.), DNA 
sequences required for the in vitro replication of adenovirus DNA. Proc. Natl. Acad. 
Sci. 81:3069-3073, 1984. 

Krug, R.M. (with Braam, J., and Ulmanen, I.), Molecular model of a eucaryotic transcription 
complex: functions and movements of influenza P. proteins during capped RNA- 
primed transcription. Cell 34:609-618, 1983. 

Krug, R.M. (with Ulmanen, [., and Broni, B.), Influenza virus temperature-sensitive cap 
(m7GpppNm)-depcndent endonuclease. J. Virol. 45:27-35, 1983. 

Lacy, E. (with Roberts, S., Evans, E.P., Burtenshaw, M.D., and Costantini, F ), A foreign 

B-globin gene in transgenic mice: Integration at abnormal chromosomal positions and 
expression in inappropriate tissues. Cell 34:343-358, 1983. 

Marians, K.J., (with Grccnbaum, J.H.), The interaction of Escherichia colt replication factor Y 
with complementary strand origins of DNA replication. J. Biol. Chem. 
259:2594-2601, 1984. 

Marians, K.J., (with Abarzua, P.), Enzymatic techniques for the isolation of random single-base 
substitutions in vitro at high frequency. Proc. Natl. Acad. Sci. 81:2030-2034, 1984. 

Melera, P.W. (with Bicdler.J., Chang, T-D., Peterson, R.H.F., Myers, M.B., and Spenglcr, 
A.B.), Gene amplification and phenotypic instability in drug-resistant and revertant 
cells. In: Rational Basis for Chemotherapy. B.A. Chabner, cd. New York: A.R. Liss. 
71-92, 1983- 

Melera, P.W. (with Montgomery, K.T., Biedler. J.L. , and Spengler, B.A.), Specific DNA 
sequence amplification in human neuroblastoma cells. Proc. Natl. Acad. Sci. 
80:5724-5728, 1983. 

Modak, M.J. (with Abraham. K.I., and Haley, B ), Biochemistry of terminal deoxynucleotidyl- 
transferase: characterization and properties of photoaffinity labeling with 8- 
azadoadenosine 5 -triphosphate. Biochemistry 18:4197-4203, 1983. 

Modak, M.J. (with Srivastava, S.K., and Abraham, K.I.), The mechanism of inhibition of 
avian myeloblastosis virus reverse transcriptase by a dialdehyde derivative of ATP. 
Biochem. Biophys. Acta. 745:194-201, 1983. 

Oliff, A. I. (with Mirenda, C, and Collins, L.), Molecular cloning of Friend mink cell focus 

inducing virus: Identification of MCF-like messages in normal and transformed cells. 
J. Virol. 48:542-546, 1983. 

Oliff, A.I. (with Ruscctti, S.), A 2.4 kilobase-pair fragment of the F-MuLV genome contains 
the sequences responsible for the F-MuLV induced erythroleukemia. J. Virol. 
46:718-725, 1983. 

Pinter, A. (with Honnen, W.J.), Comparison of structural domains of gp70s of ecotropic Akv 
and dualtropic MCF-247 MuLVs. Virology 129:40-50, 1983. 

Pinter, A. (with Honnen, W.J.), Topography of murine lukemia virus envelope proteins: 
characterization of transmembrane components. J. Virol. 46:1056-1060, 1983. 

Ravctch.J.V. (with Korsmeycr, S.J., Arnold, A., Bakhshi, A., Siebcnlist, U., Hieter, P. A., 
Sharrow. S.O., Lebien, T.W., Kersey, J. H., Poplack, D C, Leder, P., and 
Waldmann, T.A.), Immunoglobulin gene rearrangement and cell surface antigen ex- 
pression in acute lymphocytic leukemias of T cell and B cell precursor origins. J. Clin. 
Invest. 71:301-313. 1983. 



53 



Rosen, O.M. (with Herrera, R. Olowc, Y., Petruzzelli, L.M., and Cobb, M.H.), Phosphory- 
lation activates the insulin receptor tyrosine protein kinase. Proc. Natl. Acad. Sci. 
80:3237-3240, 1983. 

Rosen, O.M. (with Petruzzelli, L., and Herrera, R.), Insulin receptor is an insulin-dependent 
tyrosine protein kinase: Copurification of insulin-binding activity and protein kinase 
activity to homogeneity from human placenta. Proc. Natl. Acad. Sci. 81:3327-3331, 
1984. 

Rosenberg, B.H. (with Lockhart, M.L.), Inhibition of DNA synthesis, independent of DNA 
adduct formation, by benzo[a] pyrene diol epoxide in mammalian cells. Carcino- 
genesis 4:125-130, 1983. 

Sarkar, N.H. (with Racevskis, J.), Expression and disposition of the murine tumor virus 
(MuMTV) envelope gene products by murine mammary tumor cells. Virology 

126:279-300, 1983. 

Sarkar, N.H. (with Telang, N.T.), Long-term survival of adult mouse mammary glands in 
culture and their response to a retinoid. Cancer Res. 43:4891-4900, 1983. 

Sen, G.C. (with Herz, R.E.), Differential antiviral effects of interferon in three murine 
cell lines. J. Virol. 45:1017-1027, 1983. 

Sen, G.C. (with Pinter, A.), Interferon-mediated inhibition of production of Gazdar murine 
sarcoma virus, a retrovirus lacking env proteins and containing an uncleaved gag 
precursor. Virology 26:403-407, 1983. 

Stavnezer, E. (with Boccara, M., Souyri, M., Magarian, C, and Fleissner, E.), Evidence for a 

new form of retroviral env transcript in leukemic and normal mouse lymphoid cells. J. 
Virol. 48:102-109, 1983. 

Stavnezer, J., Molecular genetics of immunoglobulin heavy chain switching. Surv. Immunol. 
Res. 2:267-270, 1983. 



54 



Requirements and Course Offerings 



55 



Admission 



Applications 

For admission to the Graduate School of Medical Sciences an applicant must 
(1) have a baccalaureate degree or the equivalent from a college or university 
of recognized standing, (2) have adequate preparation in the chosen field of 
study, and (3) show promise of ability to pursue advanced study and research, 
as judged by his or her previous record. 

Inquiries about graduate study should be addressed to the Associate Dean 
of the Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 
10021 or to the Associate Director of the Sloan-Kettering Division, 1275 York 
Avenue, New York, NY 10021. 

Candidates may be admitted in September, February, or July, although 
places in the graduate program for February and July may not be available be- 
cause of prior commitments to applicants for September admission. Applicants 
for February or July admission should correspond directly with the respective 
Field Director in the Medical College Division or the Associate Director of the 
Sloan-Kettering Division regarding the availability of places. 

Application material must be completed and returned to the Office of 
the Dean together with (1) official transcripts of records from all colleges and 
universities attended, (2) a statement of purpose of graduate study, and (3) two 
letters of recommendation from individuals in academic positions who know 
the applicant professionally. In addition, scores from the Graduate Record 
Examinations are usually required to aid in the evaluation of an applicant. 
Application for taking the Graduate Record Examinations (GRE's), the Aptitude 
(Verbal, Quantitative, and Analytical) Test and the Advanced Test, must be 
made directly to the 

Educational Testing Service 
Graduate Record Examinations 
Box 955 

Princeton, NJ 08541 

The proper Institution Code Number to use in your GRE application for 
the Cornell University Graduate School of Medical Sciences (New York City) is 
R 2119-6. 

Applications for September or July admission and all credentials, includ- 
ing official transcripts of records from all colleges and universities attended, 
must be received by the deadline date of February I. 

Applications and credentials for February admission must be received by 
November 1 . 

Application fee. A nonrefundable charge of $25 is made for filing an 
application for admission. 

The completed application and all supporting documents are reviewed by 



57 



by the Division Credentials Committee. Applicants who are considered poten- 
tially acceptable are usually called for a personal interview. At the time of in- 
terview, after discussing his or her interests with the members of the Field or 
Unit, the applicant may tentatively select a major sponsor. If accepted by the 
Field or Unit, an application is returned to the Dean who may refer it to the 
Executive Committee for final review and decision. A student is formally 
notified of acceptance for study in the Graduate School of Medical Sciences by 
a letter from the Dean. An applicant accepted for admission is requested to 
inform the Graduate School of Medical Sciences of her or his plan to either 
accept or refuse the offer of admission within one month after the Dean's 
acceptance letter has been received. 

It is the policy of Cornell University to actively support equality of educa- 
tional and employment opportunity. No person shall be denied admission to 
any educational program or activity or be denied employment on the basis of 
any legally prohibited discrimination involving, but not limited to, such factors 
as race, color, creed, religion, national or ethnic origin, sex, age, or handicap. 
The University is committed to the maintenance of affirmative action programs 
which will assure the continuation of such equality of opportunity. 

Admission policies are also in conformity with the policy of New York 
State in regard to the American ideal of equality of opportunity as embodied 
in the Education Practices Act. 

Categories 

An applicant is accepted by the Graduate School of Medical Sciences (1) as a 
degree candidate for the M.S. or Ph.D., or (2) as a provisional candidate. 

Provisional candidacy provides opportunity for a prospective degree can- 
didate, whose educational preparation is difficult to evaluate, to begin graduate 
studies. On the basis of the record of accomplishment in the first half of the 
academic year, the adviser or temporary Special Committee of a provisional 
candidate may recommend to the Dean that (1) provisional candidacy be 
changed to degree candidacy, (2) provisional candidacy be continued for the 
remainder of the academic year, or (3) provisional candidacy be terminated. A 
maximum of one academic year in the status of provisional candidacy is per- 
mitted and credit of a maximum of one residence unit may be allowed on 
petition, provided there is convincing evidence that performance has been of 
the same quality as that required of degree candidates. 

Special Students 

Special students are students who are not degree candidates in either the 
Graduate School of Medical Sciences or the Medical College and who are given 
permission by the respective dean to take courses at either school. Special stu- 
dents must be degree candidates at other institutions and the courses taken at 



58 



Cornell must be essential to their degree programs and are not offered by the 
institutions at which they are matriculated as degree candidates as certified by 
the institutions. Enrollment as a special student is not intended as preparation 
for admission to degree programs at Cornell or elsewhere. 

In the case of the Graduate School of Medical Sciences, special students 
are accepted only with the approval of the appropriate Field Director in the 
Medical College Divission or of the appropriate Chairperson in the Sloan - 
Kettering Division. Special students must demonstrate special qualifications in 
terms of preparation and ability. They must register with the appropriate office 
in the Graduate School of Medical Sciences or in the Medical College and must 
pay all tuition and fees before being permitted to attend lectures or laboratory 
sessions. Tuition is computed on the basis of the ratio of course hours taken to 
the total hours of instruction for the academic year (33 weeks of 40 hours). 
There is a registration tee of $25. 

Degree Requirements 

Major and Minor Fields* 

A candidate for the degree of Master of Science is required to register for study 
in one major and one minor field. Each field decides whether the Special 
Committee of a candidate for the Ph.D. degree must have two or three fields 
represented. Accordingly, a candidate for the degree of Doctor of Philosophy 
is required to register for study in one major and one or two minor fields. At 
least one of the minors must be outside the area of the major field. 

The Special Committee 

The general degree requirements of the Graduate School of Medical Sciences 
are minimal in order to give maximum flexibility in choosing a desirable pro- 
gram of study. The student's program is determined with the aid and direction 
of a Special Committee, consisting of at least three faculty members chosen by 
the student from those fields that best fit his or her areas of interest. Satisfac- 
tory progress toward a degree is judged by the committee rather than by ar- 
bitrary standards imposed by the Graduate School of Medical Sciences. There 
are no regulations of the Faculty of the Graduate School of Medical Sciences 
governing the specific content of instruction, courses, or grades to which the 
Special Committee must subscribe, except those imposed by the fields. The 
committee is primarily responsible for the candidate's development as an inde- 
pendent scholar and scientist. 

"Areas of concentration towards a degree at the Cornell University Graduate School of Medical 
Sciences are referred to as Fields in the Medical College Division and as Units in the Sloan- 
Kettering Division. Both these terms are intended to be covered by the term field m this and 
subsequent sections. 



59 



No later than four weeks after enrollment, a candidate must file a state- 
ment of the major and minor fields elected for study, after which the student 
must choose faculty members to represent the fields and to serve on a Special 
Committee. The faculty member representing the major field usually advises 
the student concerning the other selections and chairs the committee. At least 
one member of the committee must represent a field different from the candi- 
date's major field. Members may agree to serve temporarily during the candi- 
date's first year of residence until the candidate has had the opportunity to 
become acquainted with areas of research in the fields of his or her choice. On 
completion of this year of residence, a permanent Special Committee will be 
formed, the membership of which can be changed with agreement of all 
members of the old and newly formed committees and the approval of the 
Dean. The members of the Special Committee decide on the student's pro- 
gram of study and research, and judge whether progress toward a degree is 
satisfactory. After consulting the other members, the chairperson of the 
Special Committee prepares term reports on the candidate for submission to 
the Dean. The members of the committee serve on all the candidate's examin- 
ing committees and they approve his or her thesis. 

Registration and Course Grades 

No student in the Graduate School of Medical Sciences may double-register 
for an advanced general or professional degree with any other school or college 
except the Cornell University Medical College. 

At the beginning of each term, students are required to register with the 
Office of the Graduate School of Medical Sciences and to file a registration of 
courses form indicating all courses they will take. A fee of $10 is charged for 
late registration. 

At the beginning of each course in which the student is enrolling, the 
student will complete a separate course registration form for the instructor. All 
courses for which the student registers for credit will be entered in the official 
record. Grades of graduate students are reported as: Excellent (E), Satisfactory 
(S), Unsatisfactory (U), Incomplete (I), Absent (Abs.), or Unofficially With- 
drawn (W). A grade of Incomplete or Absent cannot be changed later than 
one term following the one in which the course was taken. 

Registration for the summer is required of graduate students who will be 
engaged in research. 

Residence 

The Faculty of the Graduate School of Medical Sciences regards study in resi- 
dence as essential. Each candidate for an advanced general degree is expected 
to complete the residence requirements with reasonable continuity. A student 
must register each term from the time of his or her first registration in the 



60 



Graduate School of Medical Sciences until the student cither withdraws or 
completes a degree (unless a leave of absence has been granted). Full-time 
study for one-half academic year with satisfactory accomplishment constitutes 
one residence unit. Two units of residence are the minimal requirement for 
the master's degree and six units arc the minimum for the doctoral degree 
However, the time necessary to obtain the degree generally exceeds the mini- 
mal requirements. A candidate for the Ph.D. degree must spend two of the 
last four units of required residence in successive terms on the New York City 
or the Ithaca campus of Cornell University. No more than seven years may 
intervene between the time of first registration and the completion of all re- 
quirements for the doctoral degree. A student must complete all requirements 
for the master's degree in four years. 

Part-time graduate study, if it is necessitated by off-campus employment 
noncontributory to the major field of study, is not encouraged. Requests for 
part-time study must be reviewed by the Executive Committee. If permission is 
granted for part-time study, the student must be in residence at least half-time. 

The legislation with respect to eligibility of part-time students for residence 
units is as follows: 



Employment 


Residence Units All 


owable Per Half Academic Year 


Total 

clock hours 
per week 


Contributory in 
major field; 
on campus 


Noncontributory ; 
on campus 


Off Campus 


0-10 hours 
11-20 hours 
21-30 hours 


1 unit 
1 unit 

3 /4 unit (teaching) 
3 /4-l unit (research)* 


1 unit 
3 /4 unit 
l /i unit 


3 /4 unit 
3 /4 unit 


"Time spent assisting in research, if it is contributory to the major field 
credited toward allowance of a full residence unit. 


of study, shall be 



Transfer of Residence Credit 

No residence credit will be granted for study outside the Graduate School of 
Medical Sciences to fulfill the requirements of the M.S. degree. No commit- 
ment can be made about granting residence credit toward the Ph.D. require- 
ments for previous study in another graduate school until after the candidate 
has entered into residence at the Graduate School of Medical Sciences. At that 
time, the student's Special Committee may recommend acceptance of study 
outside the Graduate School of Medical Sciences to the Executive Committee, 
which will determine the number of residence units to be awarded. No credit 
can be transferred for study undertaken as an undergraduate or as a special 



61 



student even in courses designed for graduate students. 

A student who has satisfactorily completed two or more academic years of 
study toward the degree of M.D. at the Cornell University Medical College, or 
another accredited medical school in the United States with a curriculum 
equivalent to that of the Cornell University Medical College, may transfer a 
maximum of two units of residence credit after passing an evaluation examina- 
tion administered by a committee appointed by the Executive Committee of 
the Graduate School of Medical Sciences. 

Summer Research 

Registration is required for the summer research term whether or not this ef- 
fort will be credited toward residence unit accumulation. Students registered 
for summer research pay prorated tuition only if they are obtaining residence 
credit. However, no degree candidate is eligible for more than two residence 
units in any period of twelve consecutive months. 

Study In Absentia 

A candidate for the degree of Doctor of Philosophy may petition for permission 
to earn residence units for study away from Cornell University while regularly 
registered in the Graduate School of Medical Sciences. A candidate to whom 
this privilege has been granted, must register as a Candidate in absentia and 
may work temporarily under the immediate supervision of an individual desig- 
nated by his or her Special Committee although the candidate's program will 
continue to be directed by the Committee. For study in absentia, not more 
than two residence units may be earned toward fulfillment of the minimal 
residence requirements for the Ph.D. degree. 

Leave of Absence 

A candidate who finds it necessary to interrupt the continuity of his or her 
residence must petition the Dean for an official leave of absence. This written 
petition must specify the term of absence, state the reason for the requested 
leave of absence, and be approved by the student's Special Committee. 

A student who will not be in residence but will return to the Graduate 
School of Medical Sciences to present and defend a thesis at the final examina- 
tion, having completed all requirements for a degree except for the final ex- 
amination, must petition for a leave of absence. 

Examinations 

Three examinations are required by the Faculty of the Graduate School of 
Medical Sciences: (1) Final Examination for the M.S. degree, (2) Examination 
for Admission to Doctoral Candidacy, and (3) Final Examination for the Ph.D-. 



62 



degree. Examinations are administered by an Examining Committee consisting 
of a chairperson appointed by the Dean, the members of the candidate's 
Special Committee, and, in the case of the Admission to Doctoral Candidacy 
Examination, three additional members selected from the Faculty of the 
Graduate School of Medical Sciences and /or of other institutions. In addition 
to these examinations, the candidate's major field may require a qualifying ex- 
amination as part of its evaluation of the candidate after two units of residence 
have been completed. 

For the M.S. degree: The Final Examination may be oral or both oral and 
written. 

For the Ph.D. degree: The Admission to Doctoral Candidacy Examination 
is both oral and written and certifies that the student is eligible to present a 
thesis to the Faculty of the Graduate School of Medical Sciences. The examina- 
tion should be taken after course work is largely finished but before significant 
thesis research has begun. Accordingly, the usual examination time will be at 
the end of the second year of residence. The examination may not be taken 
until two units of residence credit have been accumulated and a minimum of 
two units of residence credit is required after passing this examination before 
the final examination can be scheduled. The final examination for the Ph.D. 
degree is an oral defense of the candidate's thesis. It must be passed within 
four years after completion of the required residence units, or within seven 
years from the date of first registration, whichever is earlier. 

Foreign Language Requirements 

Each field of study has its own foreign language requirements. The student's 
Special Committee may require knowledge of foreign languages beyond the 
requirements of the fields listed in this Announcement . 

Arrangements for a foreign language examination will be made on appli- 
cation to the Office of the Dean. As an alternative to this examination, the 
candidate may demonstrate proficiency by having passed the reading part of the 
language qualification tests administered by the College Entrance Examination 
Board. 

Thesis 

A principal requirement for both the M.S. and the Ph.D. degrees is the pre- 
sentation of a thesis constituting an imaginative contribution to knowledge. 
Ordinarily, the thesis is written on a research topic in the candidate's major 
field of study, under the direction of the chairperson of his or her Special 
Committee. The faculty requires that the Ph.D. thesis be published in abstract 
and be recorded on microfilm. 



63 



Tuition and Fees 



Tuition 

Tuition for a student regularly matriculated in the Graduate School of Medical 
Sciences is $9,600 for the academic year 1984-85 and is payable in two equal 
parts, the first of which is due at initial registration. Tuition includes fees for 
matriculation, hospitalization insurance, graduation, and miscellaneous thesis 
expenses. 

For students who (1) have been in continuous residence at Cornell in the 
same doctoral program and have accumulated four units of residence credit, 
(2) have passed their Admission to Doctoral Candidacy Examination, and (3) are 
not taking courses in the Medical College curriculum, a reduced charge of $1800 
per annum ($900 per semester) will be made for tuition and fees for the terms 
subsequent to the Admission to Doctoral Candidacy Examination. For those 
students who are accepted in the Ph.D.-M.D. Program (see p. 69) and will 
continue to take courses in the medical curriculum, an additional tuition 
charge, based on the Medical College tuition ($13,660 per annum), will be 
made for the medical course hours taken. 

A student who is to receive partial residence credit (see p. 61) because of 
employment should apply for proration of tuition on forms obtainable at the 
Office of the Dean. Proration of tuition does not apply to the special reduced 
tuition of $900 per semester. 

Other Fees 

In Absentia A student registered in absentia pays a fee of $200 each term 
and may continue hospitalization insurance by payment of the annual premium 
directly to the Student Accounting Office. If students in absentia take advan- 
tage of local privileges, such as the use of the library, desk space, Student 
Health Service, and Cornell housing, the fee is $400 per semester. The latter 
fee also covers hospitalization insurance. 

Leave of Absence Students on leave of absence will be required to pay an 
active-file fee of $200 for each semester, up to a maximum of six semesters, 
during which they are not registered with the Graduate School. This fee will 
not be subject to finance charges but must be paid before the student can 
receive an advanced degree. Petition for waiver of this fee will be considered 
for students who have not completed the required number of residence units. 

Candidate for Degree Only A graduate student who has previously fulfilled 
all other degree requirements, who has been granted a leave of absence, and 
who returns to the Graduate School of Medical Sciences to present a thesis and 
to take the final examination must register as a Candidate for Degree Only. 



64 



Any individual who owes money to the University will not be allowed to 
register or reregister in the University, receive a transcript of his or her record, 
have his or her academic credits certified, be granted a leave of absence, or 
have a degree conferred. 

The amount, time, and manner of payment of tuition, fees, or other 
charges may be changed at any time without notice. 

Refunds 

Part of the amount personally paid for tuition will be refunded if the student 
obtains official certification of leave of absence or withdrawal from the Grad- 
uate School of Medical Sciences during the semester. Students who terminate 
t licit registration during a regular term in this manner will be charged tuition 
from the registration day to the effective date of the certificate as follows: first 
week, 10 percent; second week, 20 percent; third week, 30 percent; fourth 
week, 40 percent; fifth week, 60 percent; sixth week, 80 percent; seventh 
week, 100 percent. No charge will be made if the effective date of leave or 
withdrawal is within the first six days of the term, including registration day. 

Financial Assistance 

All applicants to the Graduate School are requested to submit a Graduate and 
Professional School Financial Aid Service (GAPSFAS) form providing an esti- 
mate of financial need. The information will be used in two ways: The num- 
ber of students with documentable need will allow the University to obtain 
maximum federal funding for loans and work-study purposes, and the specific 
need of an applicant may be used to determine that individual's graduate sup- 
port. Please obtain the necessary form, available at your college or university 
financial aid office and from the Educational Testing Service. File the form 
with the Educational Testing Service, Box 2614, Princeton, Newjersey 08541, 
and request that the information be sent to Cornell-Code 2267. 

Financial assistance is available to qualified applicants. Individual fields 
may offer predoctoral research fellowships, research assistantships, or teaching 
assistantships. These positions may provide a stipend in addition to tuition. 
Information about these positions may be obtained directly from the Field or 
Unit at the time of application. 

Nationwide competitive predoctoral fellowships are available from the 
National Science Foundation and the National Research Council. Information 
about these fellowships should be requested directly from the appropriate 
governmental agency. 

New York State residents are eligible for several predoctoral fellowships 
and the Tuition Assistance Program, which assists in tuition payments. Appli- 



65 



cation forms may be obtained from the New York Higher Education Services 
Corporation, Student Financial Aid Section, Tower Building, Empire State 
Plaza, Albany, NY 12255. 

Several loan programs are available to graduate students. Under these 
programs, repayment of the principal amount of the loan together with the 
interest on the loan may be deferred until after graduation. Complete infor- 
mation regarding loan programs may be obtained from the Graduate School 
Office. 

Opportunity for part-time employment is often available in departmental 
research projects or other activities. Applications should be made directly to 
individual departments. 

The Graduate School of Medical Sciences participates in the Work-Study 
Program of Cornell University. For the 1984-85 academic year, the maximum 
contribution to a student's salary is $2,800. 

Scholarships and Fellowships 

Full fellowships are provided for graduate students by both the Medical College 
and Sloan-Kettering Divisions of the Graduate School of Medical Sciences. 
Recipients of this award become Ph.D. Fellows and will receive a full tuition 
scholarship and a stipend covering living expenses. 

In addition, a number of tuition scholarships are available for students in 
the Medical College Division who are not covered by one of the above fellow- 
ships. This scholarship fund is administered by the Office of the Dean of the 
Graduate School of Medical Sciences. 

The Vincent Astor Scholarship Fund. Funds for limited tuition assistance are 
also derived from the income from a generous gift by the Vincent Astor Foun- 
dation to the Graduate School of Medical Sciences and to the Medical College. 
Allocation of these funds for graduate student tuition assistance is made at the 
discretion of the Dean of the Graduate School of Medical Sciences on the 
recommendations of the Field Directors in the Medical College Division and of 
the Associate Director of the Sloan-Kettering Division. 

The Frank R. and Blanche A. Mowrer Memorial Fund. Limited financial 
assistance is available from the income of this fund to one student per year 
enrolled in the Ph.D.-M.D. or M.D.-Ph.D. program. 

Awards and Prizes 

The Frank Lappin Horsfall Jr. Award is endowed by funds provided in 
memory of Dr. Horsfall by his many friends and family. It is continued evi- 
dence of his concern for students manifest during his directorship of the Sloan- . 



66 



Kettering Division. 

The award is made annually to a student of the Sloan-Kcttering Division, 
who in the opinion of the Committee of the Faculty of the Sloan-Kcttering 
Division, has heen most distinguished, especially in the Admission to Doctoral 
Candidacy Examination. 

Recipient of the award in 1984 was Janet Braam. 

The Julian R. Rachele Prize. The income of a fund established by Dr. Julian 
R. Rachele, former Dean of the Cornell University Graduate School of Medical 
Sciences, provides for an annual prize to be awarded to a candidate for the 
Ph.D. degree for a research paper of which the candidate is the sole or the 
senior author. This paper must have been accepted during the twelve-month 
period ending 30 April for publication in a scientific journal representing one 
of the fields of the Graduate School of Medical Sciences. In order to qualify 
for the prize, a student must have passed the Admission to Doctoral Candidacy 
Examination. 

A candidate for the prize must submit a copy of the manuscript to the 
Dean by 30 April for evaluation by an ad hoc committee appointed by the 
Dean. Manuscripts received after 30 April will be considered for the award in 
the subsequent year. 

Recipient of the prize in 1984 was Susan M. Fitzpatrick. 

Student Health Services 

The Student Health Plan of Cornell University Medical College provides hos- 
pitalization and major medical insurance for all registered graduated students. 
In addition, the Plan provides for ambulatory care at the Personnel Health 
Service of The New York Hospital-Cornell Medical Center. Physicians at the 
Health Service will refer students who require specialized care to clinics of the 
Hospital and to attending physicians of the staff. 

The cost of medical services provided by the Plan are included in the tui- 
tion and fee structure announced by the Graduate School of Medical Sciences 
each academic year. Students will be issued Plan membership cards and will 
receive courtesy privileges at The New York Hospital Pharmacy. 

Entering students are requested to have a physical examination, chest 
X-ray and laboratory tests performed by their personal physicians prior to 
matriculation. The hours of the Personnel Health Service and a complete state- 
ment of Plan benefits will be provided to each graduate student. 

It is recommended that students purchase insurance coverage for eligible 
dependents who do not have other insurance available to them. Insured de- 
pendents are not eligible for care at the Personnel Health Service but they will 
be referred to appropriate members of the Hospital staff for medical treatment. 

A student studying in absentia may continue hospitalization insurance by 



6" 



payment of the annual fees directly to the Student Accounting Office. 

A student on leave of absence is not eligible to receive student health 
benefits. 

Residence Halls 

F. W. Olin Hall, a student residence, is at 445 East Sixty-ninth Street directly 
across from the Medical College entrance on York Avenue. Olin Hall contains 
a gymnasium, lounges, and 245 residence rooms. Each residence room is fur- 
nished as a single bedroom-study, but since two rooms share a connecting 
bath, they may be used as a suite for two students. The rooms are completely 
furnished. The student housing fee is $1,750 for the 10-month academic year, 
$2,100 for the calendar year, or $175 per month for shorter periods. 

Livingston Farrand Apartments, also located on East Sixty-ninth Street, just 
beyond Olin Hall, have furnished apartments of Wz, 2, 3, and 4 rooms. Cook- 
ing facilities are provided in these apartments. Housing fees range from 
$222— $4 14 per month (utilities not included). Apartments in these facilities 
are available to married and upper-class students. 

Jacob S. Lasdon House, an apartment residence, is located at 420 East Seventieth 
Street. This building contains studio, one-bedroom, and two-bedrooom apart- 
ments and two squash courts. Apartments are fully furnished, and housing fees 
range from $380-$690 per month including utilities. Single, first-year students 
cannot be accommodated in this building. 

The fees listed above may be changed at any time without previous notice. 

Special Programs 

Application to the Medical Scientist Training Program 
(M.D.-Ph.D.) 

Successful applicants must demonstrate a strong undergraduate science prep- 
aration, and an early commitment to a career combining both clinical and 
laboratory research. They must simultaneously satisfy the separate requirements 
for admission to Cornell University Medical College and to the Divisions of the 
Graduate School of Medical Sciences. 

Applications must show whether admission is sought to the M.D.-Ph.D. 
program of the Medical College Division, the Sloan-Kettering Division, or 
both (see p. 4 for a description of the programs). Only one set of documents 
is required for applications to either or both programs. All documents must be 
forwarded to the Office of Admissions, Cornell University Medical College, 
445 East 69th Street, New York, NY 10021. (Telephone 212, 472-5673). 



68 



The following items are required, by November 30, for an application to 
be considered complete: 

1. AMCAS application. (The personal data and academic record presented 
in this application are suitable for evaluation by both the medical and 
graduate schools.) 

2. MCAT scores; GRE scores, if available. 

3. A personal statement summarizing the applicant's background, inter 
ests, and reasons for pursuing the combined program. 

4. Evaluation by the pre-medical advisory committee or two letters from 
members of the undergraduate science faculty addressing themselves 
to the applicant's suitability for a career in medicine. 

5. Evaluations by at least two faculty members addressing themselves to 
the applicant's research potential. 

6. A check for $45 to cover the application fee, made out to "Cornell 
University Medical College." 

After screening, selected applicants to the program will be invited to visit 
the Cornell Medical Center and meet with members of the faculty of the 
medical and graduate programs. These interview visits will be coordinated by 
the Medical College Admissions Office. 

Application to the Ph.D.-M.D. Program 

Applications to this program (see p. 4 for description) are ordinarily made 
after the completion of the first year of study in the Graduate School of Medical 
Sciences, although more advanced students may be considered. The deadline 
for application is February L. 

To apply, the student must submit to the Office of the Dean of the 
Graduate School of Medical Sciences: 

1. A completed application for admission with advanced standing to 
Cornell University Medical College (obtainable from the Medical 
College Admissions Office). 

2. A plan of graduate study incorporating all required course work of the 
first two years of the Medical College curriculum and endorsed by the 
student's Special Committee. 

3. Evidence of successful completion of at least two major medical school 
basic science courses (anatomical sciences, biochemistry, microbiology, 
pathology, pharmacology, physiology). 

4. Two letters of evaluation from faculty of the Graduate School of 
Medical Sciences. 

The Office of the Dean of Graduate School of Medical Sciences will review 
the student's credentials and make a recommendation to the Committee on 
Admissions of Cornell University Medical College. Only applicants who are 



64 



found to be acceptable by this committee, after review of the application and 
personal interviews, can enter the Ph.D.-M.D. Program. Final decisions will 
be made before June 1 . 

Students in this program must meet the following requirements before 
admission to the third-year clinical curriculum of the Medical College: 

1. Complete all required graduate courses and the remainder of the first 
two years of the medical school curriculum. 

2. Pass the Admission to Doctoral Candidacy Examination, required by 
the Graduate School of Medical Sciences. 

3. Complete the dissertation research; present and successfully defend an 
original thesis at the final examination for the Ph.D. degree 

After satisfactory fulfillment of the required clinical rotations of the 
Cornell third-year medical school curriculum, these students may receive credit 
for their graduate studies to satisfy the elective requirements of the fourth-year 
medical school curriculum and will then be recommended for award of the 
M.D. degree by Cornell University. 

While registered as a graduate student in the Ph.D.-M.D. Program, the 
student is subject to the tuition schedule of the Graduate School of Medical 
Sciences. Upon completion of the requirements for the Ph.D. degree, the stu- 
dent is registered in the Medical College and is subject to its tuition schedule. 



70 



Instruction at the Medical College Division 



Field of Biochemistry 

Field Director 

A. Meister, Department of Biochemistry, Room E-106, Medical College, 
(212) 472-6212 

Faculty Representative 

D. Wellner, Department of Biochemistry, Room E-219, Medical College, 
(212) 472-6197 

Graduate instruction is offered leading the the Ph.D. degree. Within the 
framework of degree requirements and in consultation with the student, the 
course of study is planned to fit the need of the individual. Although formal 
course work is required, emphasis is placed on research. Research opportunities 
exist in various areas of biochemistry including enzymology, structure and func- 
tion of proteins and nucleic acids, molecular biology, physical biochemistry, 
and the intermediary metabolism of amino acids, carbohydrates, nucleic acids, 
and lipids. Entering graduate students usually work for short periods in several 
of the laboratories of the faculty members of the Field before beginning their 
thesis research. Students are encouraged to choose challenging fundamental 
research problems that are on the frontiers of biochemistry. 

The laboratories of the faculty members are equipped with virtually all of 
the instruments and facilities required for modern biochemical research; thus, 
graduate students are instructed in such methodology as chromatography, 
countercurrent distribution, radioactive and stable isotope techniques, spectro- 
photometry, electrophoresis, and analytical ultracentrifugation. 

Students who undertake graduate study in biochemistry must have a suf- 
ficiently comprehensive background in chemistry to pursue the proposed 
course of study and must present evidence of knowledge of biology, general 
experimental physics, mathematics (including differential and integral calculus). 
Students may remedy deficiencies in these areas during the first year of 
graduate study. The Graduate Record Examinations (the Aptitude Test and 
the Advanced Test in chemistry) are ordinarily required. 

The student is required to demonstrate proficiency in one modern foreign 
language acceptable to the student's Special Committee. Proficiency in a com- 
puter programming language, as demonstrated by executing a meaningful 
program, may substitute for proficiency in a foreign language. 



'1 



Courses 



Graduate Biochemistry Offered jointly by the faculties of the Medical College 
and Sloan-Kettering Divisions. This course is designed to provide the student 
with a knowledge of the fundamentals of biochemistry and an appreciation of 
the molecular basis of biological phenomenia. Graduate students in the Field 
of Biochemistry are required to pass this course (or its equivalent). First and 
second trimesters. Drs. Haschemeyer and Lloyd. 

Advanced Biochemistry This course consists of one or more lecture series 
(minicourses) covering selected areas of current interest at an advanced level. 
The topics change from year to year and may be repeated after 2 or 3 years. 
The subjects offered include: 1) nucleic acids and protein synthesis; 2) inter- 
mediate metabolism and its regulation; 3) kinetics and enzyme mechanisms; 
4) protein and peptide microchemistry; 5) membrane structure and function; 
6) hormones; 7) computer programming for the biochemist; 8) physical 
methods in the study of macromolecular and cellular structure; 9) design of 
inhibitors of enzymes and transport systems. Prerequisite: Graduate Bio- 
chemistry. See below for courses offered in 1984-85. 

Membrane Biochemistry Third trimester. Dr. Hajjar. 

Protein and Peptide Microchemistry Third trimester. Dr. Udenfriend. 

Design of Inhibitors of Enzymes and Transport Systems First, second, 
and third trimesters. Dr. Griffith. 

Other Academic Offerings 

Introduction to Research Experimental biochemistry dealing with the isolation, 
synthesis, and analysis of substances of biochemical importance (enzymes, co- 
enzymes, various metabolites and intermediates), and study of their properties 
by various chemical and physical techniques. The student obtains this varied 
research experience by spending approximately two months in the laboratory 
of each of four faculty members of his or her choice. For incoming graduate 
students majoring in biochemistry. 

Biochemistry Seminars A seminar series in which students, faculty, and 
invited scientists from this and other institutions present on progress in their 
laboratories. 



72 



Field of Cell Biology and Genetics 
Field Director 

D.A. Fischman, Department of Cell Biology and Anatomy, Room E- 1 16, 
Medical College, (212) 472-6400 

Faculty Representative 

J.L. German III, New York Blood Center, 310 E. 67 St., New York, NY 10021, 
(212) 570-3075 

The Field of Cell Biology and Genetics offers a program of advanced study 
leading to the Ph.D. degree. The program is intended to prepare students for 
a career in basic research and teaching in cell, developmental and molecular 
biology, genetics, anatomical sciences, or related health sciences. Administra- 
tion of the Field is based in the Department of Cell Biology and Anatomy in a 
recently renovated research wing of Cornell University Medical College. Addi- 
tional laboratories are located in various departments of Cornell University 
Medical College, the Sloan-Kettering Institute, and the New York Blood 
Center. 

For graduate study in the Field, adequate undergraduate preparation in 
biology, chemistry (including organic chemistry), physics, and mathematics is 
recommended. Requirements for admission are flexible in proportion to the 
promise and accomplishments of the applicant. Applicants are requested to 
present results of the Graduate Record Examinations. 

Requirements for minor sponsorship in the Field will be arranged with 
individual students, but research experience in the minor sponsor's laboratory 
is strongly encouraged. 

Students are generally required to take Cell Biology and Microscopic 
Anatomy and at least three of the more advanced courses in genetics, molecular 
biology, cell biology, or developmental biology. 

In addition to the courses listed below, appropriate courses for graduate 
students in the Field are Biochemistry, Physiology and Biophysics, and those 
courses given by the Field of Neurobiology and Behavior. 

Students are expected during their first year to spend time and perform 
experiments in the laboratories of three faculty members of the Field. 

A reading knowledge of a foreign language is desirable. 

The Field requires a qualifying examination at the end of the first year of 
residence. At the discretion of the examining committee, the examination may 
be written, or oral, or both. The Admission to DoctoralCandidacy Examina- 
tion required by the Graduate School of Medical Sciences must be taken 
before six units of residence credit have been accumulated and before substan- 
tial progress has been made in the candidate's thesis research. 



73 



Courses 



Cell Biology and Microscopic Anatomy Offered by the Staff of the Field of 
Cell Biology and Genetics, Medical College Division, in conjunction with the 
Department of Cell Biology and Anatomy, Medical College. This course 
follows a cellular and differentiative approach aimed at understanding the 
structure-function correlates that characterize the different tissues and organs. 
Selected topics are presented in the lectures and laboratory exercises to indicate 
a pattern of study and depth of analysis that the student can be expected to 
apply to the study of cells and tissues. A microscope slide collection, presenting 
tissues and organs in a variety of physiological and developmental states, as 
well as correlative electron micrographs are provided for individual study in 
the laboratory. Students must provide their own compound microscopes 
through their departments or sponsors. First and second trimesters. 

A required component of the course for all graduate students is a 2 hour, 
weekly seminar (time to be arranged) focussing on detailed analysis of original 
literature, pertinent methods and unresolved questions related to topics in cell 
and developmental biology. The staff. 

Gross Anatomy Regional anatomy is studied principally through dissection of 
the human body. Supplementing this technique are prosections by instructors, 
tutorial group discussions, and radiographic and endoscopic demonstrations. 
Enrollment is limited and students should consult the staff early in order to 
determine the availability of places. First and second trimesters. The staff. 

Topics in Molecular Genetics The class will focus on key topics of molecular 
biology concerning gene structure and organization in prokaryotes and 
eukaryotes, chromosome structure, DNA replication, protein synthesis, and 
translational and transcriptional control. The use of genetic, biochemical, and 
molecular biological methods to study the questions experimentally will be 
covered in depth. Some topics of current interest such as immune diversity, 
oncogenes, and development will also be covered. The course will include an 
equal number of lectures and group discussions of representative research 
papers. Prerequisite: background in biological sciences. Limited to 20 
students. Second trimester. Drs. Chao and Traktman. 

Advanced Cell Biology Advanced course in cell biology with emphasis on the 
analysis of original literature. The course is aimed at a research level and would 
be of interest for students planning a career in academic medicine. Prerequi- 
sites: passing grade in Cell Biology and Microscopic Anatomy. Limited to 10 
students. Third trimester. Dr. Fischman. 

Developmental Biology Principles of descriptive, experimental, and molecular 
developmental biology will be presented, using several animal systems as ex- 
amples. Early development of the whole organism, and of cells, tissues, and 
organs will be considered. Prerequisites: microscopic anatomy, biochemistry. 



74 



Limited to 15 students. Third trimester. Drs. Bachvarova and Badcr. 

Genetics Designed to give the student a sound background in genetic theory 
and an in-depth consideration of the gene as a unit of heredity. Second tri- 
mester 1985-86. Drs. Bennett and Graf. 

Karyotyping Practical experience in chromosome analysis in the laboratory. 
Limited to 2 students. Third trimester. Dr. German. 

Ptacticum in Electron Microscopy A workshop in practical aspects of electron 
microscopy. Following a weekly one hour lecture, students will conduct specific 
protocols involved in electron microscopy. Topics to be covered include: tissue 
fixation, embedding and thin sectioning; transmission and scanning electron 
microscopy; shadow-casting of proteins and nucleic acids; immunocytochemistry; 
photography. All participants will be required to complete an independent 
project. Prerequisite: consent of instructors. Requirements for passing grade: 
completion of an independent project paper. Limited to 6 students. Offered 
every year. Not offered in 1984-85. Mr. Dennis and staff. 

Field of Microbiology 
Field Director 

K.I. Berns, Department of Microbiology, Room B-202, Medical College, 
(212) 472-6540 

Faculty Representative 

R.W. Dickerman, Department of Microbiology, Room B-204, Medical College, 
(212) 472-6189 

The Field of Microbiology offers graduate training leading to the Ph.D. degree. 
Under special circumstances, candidacy towards the M.S. degree will be con- 
sidered. Candidates may select an area of research from such microbiological 
topics as general and medical bacteriology, microbial chemistry and physiology, 
immunology and virology, and parasitology. 

Prospective students should complete at the undergraduate level a mini- 
mum of one year (or its equivalent) in general chemistry, organic chemistry, 
general physics, mathematics (including college algebra), botany or zoology 
(preferably both), and one semester or its equivalent of analytical or quantita- 
tive chemistry. General microbiology or bacteriology and calculus are strongly 
recommended. Students who have not completed the above requirements may 
be admitted to graduate study on the condition that deficiencies be corrected 
soon after admission. Applicants are ordinarily required to present Graduate 
Record Examinations scores for the Aptitude Tests and for the Advanced Test 
in chemistry or biology. 



7S 



Individual programs are determined by the student's Special Committee, 
composed of faculty members representing the major and minor fields. Stu- 
dents majoring in microbiology select their primary courses from those listed 
below. The nature and number of other courses that may be taken at this in- 
stitution or at nearby universities will depend on the students' minor fields, 
their research activities, their individual interests, and the advice of the Special 
Committees. All students majoring in microbiology are required to assist in 
the teaching of courses offered by the Field. 

Students majoring in other fields who elect to minor in microbiology are 
ordinarily required to take the course Microbiology and an Introduction to 
Infectious Disease. In addition, students are required to enroll in an advanced 
course in microbiology or participate in a research project in the laboratory of 
their minor sponsors. In general this research is expected to take one to three 
months to complete, depending upon whether the project is pursued on a 
full-time or part-time basis. 

Although a qualifying examination is generally not given, a student's 
Special Committee has the prerogative of requiring it. The Admission to 
Doctoral Candidacy Examination must be taken by all Ph.D. candidates. The 
written portion of this examination tests for basic facts and concepts in the 
candidate's area of study and for the candidate's problem-solving ability 
within and across disciplinary boundaries. The oral examination provides an 
opportunity for the student to correct deficiencies in the written examination, 
to be examined further on general knowledge, and to discuss and be ques- 
tioned on his or her planned or current research. 

Courses 

Microbiology and an Introduction to Infectious Disease Consists of laboratory 
exercises, lectures, and group discussions. The laboratory work includes an 
introduction to the procedures used in studying microorganisms, exercises on 
various physical and biological manifestations of antigen-antibody reactions, 
the actions of chemotherapeutic agents, a survey of the microbial flora of the 
upper respiratory and lower intestinal tracts of healthy humans, and an intensive 
study of the causal agents of specific infections, including fungi, spirochetes, 
rickettsiae, and viruses, as well as bacteria. The lectures are directed toward the 
development of basic concepts, particularly the principles involved in microbial 
growth, the principles underlying active immunization, and the factors that 
enter into host-parasite relationships. Emphasis is placed on aspects related to 
the etiology, pathogenesis, epidemiology, and prevention of infectious disease. 
Special attention is also given to the principles underlying the induction and 
biological manifestations of the immune response. Offered every year in the 
first and second trimesters. Microbiology staff and invited lecturers. 

Advanced Diagnostic Microbiology The lecture and laboratory sessions ac- 



76 



quaint the student with the procedures used in and techniques of management 
of a clinical microbiology laboratory. Emphasis is upon developing the student's 
capability in the isolation and rapid identificaiton of organisms from various 
types of clinical specimens. Liberal use is made of clinical materials available 
through the diagnostic laboratories of the New York Hospital. Offered every 
year in the third trimester. Hours by arrangement. Dr. Senterfit. 

Microbiology Seminar Reports on surveys of the literature in the field and on 
current research. Presented by graduate students, faculty, and visiting scientists. 
Attendance is required of all students majoring or minoring in microbiology 
throughout their programs of study. Offered yearly and throughout the year. 
Dr. Sussdorf. 

Other Academic Offerings 

Clinical Microbiology Program — Ithaca and New York Campuses During the 
senior year of a special undergraduate study program on the Ithaca campus or 
during the year after receiving a bachelor's degree, the student may concen- 
trate on developing skills in clinical microbiology at the Cornell University 
Medical College-New York Hospital in New York City. Students participate in 
courses concerned with microbiology, an introduction to infectious diseases, 
diagnostic microbiology, parasitology, immunology, and virology, in addition 
to working in the hospital diagnostic laboratory. This clinical microbiology 
specialization is designed to prepare students for employment in clinical micro- 
biology laboratories. However, it could also be selected by students interested 
in further education or other careers. Dr. Senterfit. 



Field of Neurobiology and Behavior 
Field Director 

T.H. Joh, Department of Neurology, Kips Bay Building, Medical College, 
(212) 472-5594 

Faculty Representative 

G.E. Gibson, Department of Neurology, Burke Rehabilitation Center, 
White Plains, NY, (914) 948-0050, Ext. 2291 

The Field of Neurobiology and Behavior provides training in the study of the 
nervous system. It includes the disciplines of neuroanatomy, neuroembryology, 
neurophysiology, neuropharmacology, neurochemistry, neuroendocrinology, 
molecular biology, and neuropsychology and perception. The program of the 
Field emphasizes a multi-disciplinary approach to the study of the nervous 
system, based on the belief that future advances in our understanding of the 



77 



nervous system will be derived from the thinking and research techniques 
employed by more than one discipline. Toward this end, the program of the 
students entering the Field is planned in consultation with several staff 
members, and the students are expected to spend some period of time work- 
ing closely with members of the faculty whose interests are related to theirs. In 
addition, there are regularly scheduled seminars in the Field during which 
various aspects of work in progress are presented and discussed. By these means, 
the students are afforded the broadest possible view of the Field during their 
total training experience. 

The student majoring in Neurobiology and Behavior will be required to 
satisfy the requirements of the courses in neuroscience, statistics, and bio- 
mathematics, and two in the following areas: microscopic anatomy, physiology, 
biochemistry, and pharmacology. The student must also have two minors, at 
least one of which is outside the Field. In addition, participation in the 
seminar program and advanced course offerings is expected. While there are 
no language requirements, it is suggested that the student achieve mastery of 
a modern foreign language or a computer programming language. The student 
choosing Neurobiology and Behavior as a minor is required to participate in 
the neuroscience course and the seminar program as well as obtain any addi- 
tional experience that the minor sponsor may suggest. 

Applicants to the Field are expected to have had adequate undergraduate 
training in biology, organic chemistry, physics, and mathematics. Graduate 
Record Examination scores are to be submitted with the application. An inter- 
view with the applicant is considered highly desirable. 

Courses 

Neuroscience This is the basic undergraduate medical school course and is re- 
quired of all major and minor candidates in the Field. It is a broadly based 
course and introduces the student to neuroanatomy, neurophysiology, and 
pertinent neurology. Third trimester. Drs. Brooks and Grafstein. 

Neuroscience Seminar Current topics of neurosciences not included or mini- 
mally covered in the Neuroscience course, are examined in detail. The course 
is required of all major candidates in the Field and is an elective course for 
medical students. Third trimester. Drs. Brooks and Grafstein. 

Advanced Neurobiology: Molecular Neurobiology and Neurochemistry This 
advanced neurobiology course is taught by selected faculty members of the 
Cornell University Medical College and Rockefeller University and introduces 
basic molecular neurobiology and neurochemistry as well as current research 
activities in the Field. Prerequisites: neuroscience and biochemistry. The 
course is required of all major candidates in the Field, and is an elective course 
for medical students. First trimester. Drs. Joh and Gibson. 

Neuropharmacology (see Field of Pharmacology). 



78 



Field of Pathology 



Field Director 

J.T. Ellis, Department of Pathology, Room C-3 14, Medical College, 
(212) 472-5940 

Faculty Representative 

C.G. Becker, Department of Pathology, Room C-444, Medical College, 
(212) 472-5983 

Pathology is the study of the causes and mechanisms of disease processes. The 
purpose of a graduate program in pathology is to provide individuals with a 
baccalaureate or medical degree with basic knowledge of disease processes 
through study of the disciplines of anatomic and clinical pathology and by 
learning modern techniques of biological investigation. It is hoped that a stu- 
dent completing this program will have both the information and technical 
skills to make significant inquiries into the nature of disease processes and to 
bridge the gap between classical, descriptive pathology and such disciplines as 
biochemistry and molecular biology. 

The graduate program in pathology includes the observation of diseases 
in their various forms at autopsy and in clinical laboratories, and study and 
research in the areas of immunology and immunopathology, oncology, virology, 
cellular biology, and electron microscopy. It may also include study in advanced 
mathematics, physiology, biophysics, pharmacology, anatomy, cytochemistry 
and histochemistry, advanced biochemistry, genetics and microbiology. 

New students are required to have completed mathematics through inte- 
gral calculus, chemistry through organic chemistry (although physical chem- 
istry is recommended), basic physics and at least general biology. A reading 
knowledge of at least one foreign language is suggested but not required. For 
those students entering the program with baccalaureate degrees only, the 
Graduate Records Examinations, including the Aptitude Tests and the Advanced 
Test in biology or chemistry, are required. 

Graduate students in pathology are required to take the course in general 
and systemic pathology offered to second-year medical students. They must 
minor in at least one and not more than two other biomedical fields. Courses 
in biomathematics, biochemistry, genetics, and microbiology are also required. 

Courses 

General and Systemic Pathology Gross and histological lesions are studied 
and their pathogenesis and correlation with disturbed function considered. 
Lectures and classroom demonstrations are supplemented by studies at the 



79 



autopsy tabic. The course begins with cell injury, inflammation, and repairs. 
It then proceeds with the various specific infections and tumors. The latter 
part of the course is devoted to special systemic pathology, including an intro- 
duction to neuropathology. First and second trimesters. The staff. 



Field of Pharmacology 
Field Director 

W.W.Y. Chan, Department of Pharmacology, Room E-400, Medical College, 
(212) 472-6029 

Faculty Representative 

M. Okamoto, Department of Pharmacology, Room E-411, Medical College, 
(212) 472-5975 

The graduate program emphasizes sound basic training in general pharmacology. 
Then, by means of individual instruction, the candidate receives exposure to 
several specialty areas of pharmacology. The 'latter part of the graduate curricu- 
lum is devoted to research in an area of the candidate's choice. 

An adequate preliminary training in organic chemistry, physical chemistry, 
biochemistry, and physiology is prerequisite to graduate work in pharmacology. 
Training in statistics is strongly recommended. 

Applicants are required to submit Graduate Record Examination scores 
for the Aptitude Tests and the Advanced Test in biology or chemistry. 

Courses 

General Pharmacology The basic pharmacology course is offered to second- 
year medical students and to qualified graduate students. It consists of lec- 
tures, laboratory work, demonstrations, and seminars given during the first 
and second trimesters. The purpose of these exercises is to teach the principles 
of pharmacology. Detailed consideration is given to the parameters of drug 
action to provide the student with the fundamental concepts essential for the 
evaluation of any drug. Consequently, the scientific basis of pharmacology is 
emphasized. Prototype drugs, essentially considered systemically, serve to illus- 
trate several mechanisms and parameters of drug action. Therapeutic applica- 
tions are considered only insofar as they illustrate principles of pharmacology 
or drug hazards. Prerequisites: biochemistry and physiology. The staff. 

Advanced Courses in Pharmacology 

Molecular Pharmacology Fundamental principles governing the effects 
of chemicals on living systems are examined from the viewpoint of drug- 
receptor interactions. Several concepts are introduced including drug 



80 



selectivity, specificity dose-response, and receptor theory. Examples of 
receptor isolation and receptor-drug interactions are discussed in detail. 
Prerequisites: An adequate background in biology, organic and physical 
chemistry, and biochemistry is required. The staff and invited lecturers. 
Offered every third year. Minimum of 10 students. Not offered in 
1984-85. 

Immunopharmacology The course focuses on the fundamentals of im- 
munologic cell reactions and explores the mechanism of therapeutic im- 
munologic regulation. Topics include: inflammatory and allergic processes; 
mechanism of cell activation; mediator release and action; cyclic nucleotides 
and prostaglandins; lymphokines, interferons and thymic hormones; im- 
munotoxicology; immunologic assays and use of biologies and drugs for 
immunotherapy. A background in immunology would be helpful but is 
not required. The course is offered jointly by the faculties of the Medical 
College and the Sloan-Kettering Divisions, and is offered every third 
year. Miminum of 10 students. Not offered in 1984-85. 

Neuropharmacology The course offers neuropharmacology of highlighted 
drugs and chemical substances which affect central nervous system. Em- 
phasis is placed on molecular mechanisms of drug actions on biochemistry 
and physiology of nervous tissue, focussing neurotransmitter mechanisms 
and cell membrane modulation as mechanisms, including neuropharma- 
cology- agents which modify the neurotransmitter actions. Several concepts 
are introduced including drug selectivity, specificity dose-response and 
receptor theory. Prerequisites: Neuroscience required. General Pharma- 
cology is recommended. Third trimester. Dr. Okamoto, Pharmacology 
and Neurobiology staff, and invited lecturers. 

Other Academic Offerings 

Research in Pharmacology Research opportunities may be arranged through- 
out the year for graduate students who are not majoring in pharmacology but 
who want some investigative experience in the discipline. Special opportunities 
are offered for work on the nervous and cardiovascular systems and in bio- 
chemical and clinical aspects of pharmacology. 

Seminars The Field of Pharmacology offers seminars in areas of interest to 
the faculty and graduate students of the field. Seminars in clinical pharma- 
cology and teaching rounds are held regularly throughout the year. The con- 
tent, format and schedule of these seminars are determined each year on the 
basis of the number and backgrounds of the interested students. 



81 



Field of Physiology and Biophysics 
Field Director 

E.E. Windhager, Department of Physiology and Biophysics, Room C-508, 
Medical College, (212) 472-5229 

Faculty Representative 

T. Maack, Department of Physiology and Biophysics, Room D-407, 
Medical College, (212) 472-5281 

Opportunities are offered toward the Ph.D. degree in several areas of physiology 
and biophysics. Ample space is available, and laboratories are well equipped 
to provide predoctoral training in a medical environment. Interested individuals 
are urged to contact the Field Director before preparing a formal application. 
Letters of inquiry should include a discussion of the educational background 
and indicate possible areas of emphasis in graduate study. There has been a 
tendency to encourage applications from individuals who have a probable in- 
terest in more than one of the areas of physiology represented within the Field. 

Applicants must have completed introductory courses in biology, inorganic 
and organic chemistry, physics, and mathematics through the level of differ- 
ential and integral calculus. Additional course work in these disciplines at the 
undergraduate level is encouraged. Applicants with otherwise exemplary records 
who lack certain course requirements will be considered for acceptance provided 
that they remedy their deficiencies while in training. 

The course of study emphasizes the importance of teaching and research 
in the preparation and development of individuals for careers in physiology. 
This goal is achieved by a combination of didactic courses, seminars, and closely 
supervised research leading toward the preparation of a satisfactory thesis. 

A special program of study will be developed for each student in consulta- 
tion with his or her Special Committee. In addition to the general requirements 
set by the Graduate School for all fields, all candidates for the doctoral degree 
in physiology will be expected to meet the following requirements: 

1. Evidence of a satisfactory background in neurosciences. Ordinarily, the 
course in neuroscience described under the Field of Neurobiology and 
Behavior, or an equivalent course, will be taken concurrently with the 
course in physiology and biophysics. 

2. Satisfactory completion of the course in physiology and biophysics, or 
an equivalent course. 

3. For majors and minors in the Field, a minimum of two elective courses 
in the Field ordinarily will be required, in addition to the course in 
physiology and biophysics. 



82 



Courses 



Physiology and Biophysics Lectures and conferences in body fluids, bioelectric 
phenomena, circulation, respiration, and gastrointestinal function. Second 
trimester. Dr. Windhager and staff. 

l ectures and conferences on kidney function, acid-base regulation, endo- 
crinology, and metabolism; and a weekly laboratory on selected aspects of 
physiology. Third trimester. Dr. Windhager and staff. 

Topics in Membrane Physiology This weekly conference is designed for Ph.D. 
and M.D.-Ph.D. students with a major or minor in Physiology and Biophysics. 
It is at a somewhat advanced level, especially in its quantitative approach to 
physiology. The aims of the conference are to train students in physiological 
concepts, to facilitate the understanding of lecture material in the physiology 
and biophysics course, and to establish close student -faculty contact. Second 
trimester. Dr. Andersen. 

Selected Topics in Kidney and Electrolyte Physiology and Pathophysiology 
Lectures, seminars and demonstrations. Topics include: (1) GFR, clearance 
concept, reabsorption and secretion of electrolytes; (2) concentrating mecha- 
nism; (3) electrophysiology of the nephron; (4) pathophysiology of potassium; 
(5) renal blood flow and its intrarenal distribution; (6) renal physiology in the 
newborn; (7) control of body fluid volume and tonicity; (8) pathology and 
pathophysiology of renal failure; urinary sediment; (9) radiology of the 
kidneys; (10) dialysis; (11) transplantation. Third trimester. Maximum of 12 
students. Dr. Windhager and staff. 



83 



Instruction at the Sloan-Kettering Division 



Graduate Seminar This weekly graduate seminar is offered each year. During 
the first trimester, second-year students will present brief reports on their 
research experiences in the laboratory rotations. First-year students may report 
on laboratory rotations, review a selected area of research, or critically review a 
research paper. The discussion is carried out principally by graduate students 
under the guidance of their major (temporary or permanent) sponsors. From 
time to time outstanding authorities are invited as guest speakers. In addition, 
students in their third and later years of graduate study address the seminars 
on the progress being made in their thesis work. 

Laboratory Rotations Throughout the year students should spend time in 
research laboratories. Arrangements for laboratory rotation should be made 
with the major sponsor. 

Minor Projects Two minor subjects are required of all students and they may 
include some laboratory training, i.e., a minor project. The major sponsor 
assumes the responsibility for monitoring the time spent on the project. Minor 
subjects should be completed before the Admission to Doctoral Candidacy 
Examination. 

Laboratory Safety and Biohazards Course All students are required to take by 
their second year the course of six basic lectures sponsored by the Sloan-Kettering 
Institute Institutional Biosafety Committee. The series covers general laboratory 
safety, the use of radioisotopes, carcinogens, primary and secondary barrier 
systems, contamination control, and hazards associated with research animals, 
and is supplemented by lectures on special topics given throughout the year. 



Unit of Cell Biology and Genetics 
Program Chairman 

J.L. Biedler, Sloan-Kettering Institute, Walker Laboratory, Room 2127, 
(914) 698-1100, Ext. 243 

Unit Chairman 

D.B. Donner, Sloan-Kettering Division, Howard Laboratory, Room 909, 
(212) 794-7871 



84 



Students will spend their first year in: 1) satisfying course and seminar require- 
ments; 2) participating in laboratory rotations; and 3) initiating one or two 
minor projects. The Unit Chairman will serve as temporary major advisor dur- 
ing this time. At the end of the first year the student's performance will be re- 
viewed and a Special Committee of three members will be selected. The Special 
Committee membership must provide multidisciplinary academic backgrounds. 

During the second academic year students should complete two minor 
projects, satisfy the requirements of the Admission to Doctoral Candidacy 
Examination and initiate a thesis project. 

Prerequisites for a major in Cell Biology and Genetics include courses in 
chemistry (through organic), biochemistry, physics, mathematics (through 
calculus) and general biological sciences (botany, zoology, microbiology, cell 
biology); physical chemistry is recommended. 

Submission of Graduate Record Examination results, in both aptitude 
and the advanced test in biology or chemistry is required. 

Programs will be determined individually on the basis of interest and 
prior experience. Students are expected to have knowledge of materials offered 
in the courses of the Unit and in microscopic anatomy. Exemption from the 
courses can be granted following the successful completion of a written exami- 
nation. Students majoring in cell biology may be advised to register for courses 
in molecular biology, genetics, biochemistry, and biostatistics. 

Courses 

Topics in Cell Biology Staff and invited lecturers will discuss the latest research 
in cell structure and function. Topics will include cellular organization, cell- 
cell recognition, cell growth and division (particularly contrasting normal and 
neoplastic development), differentiation, cell movement, and genetics and 
gametogenesis. The format will include a weekly 2-3 hour meeting with re- 
quired reading of current scientific papers and student analysis of these papers. 
Second and third trimesters. Drs. Donner and Rosen. 

Other Academic Offerings 

Tutorial in Cell Biology and Biochemistry Designed to familiarize graduate 
students with fundamental concepts of cell biology and biochemistry. Topics 
will include cell structure, organization and function, intermediary metabolism, 
and molecular biochemistry. Hours will be arranged between small groups of 
students and faculty tutors. Dr. Eisinger and staff. 

Endocrine Research in Progress Seminars Reports of on-going research by 
faculty of the Graduate School of Medical Sciences, Cornell University Medical 
College, and Rockefeller University are given weekly. 

Flow Cytometry This brief tutorial will include lectures and demonstrations 



85 



on the principles of cell measurements and sorting as they are applied to basic 
cell biology, with special emphasis on nucleic acid content, cell cycle analysis, 
differentiation and transformation. Dr. Darzynkiewicz and staff. 

Cell Culture Tutorial Instruction in tissue culture techniques will be offered 
to a limited number of students in laboratories of Unit members. Sessions can 
count as lab rotations or be expanded into minor projects. Dr. Biedler and staff. 

Cellular Differentiation Journal Club A weekly informal discussion of recent 
publications or research of common interest in cell biology and differentiation. 
Participants are responsible for choosing a presentation for the week. 
Dr. Friedman and staff. 



Unit of Developmental Therapy and Clinical Investigation 

Acting Program Co-Chairman 

J.J. Fox, Sloan-Kettering Institute, Walker Laboratory, Room 3037, 
(914) 698-1100, Ext. 225 

Unit Chairman 

F.M. Sirotnak, Sloan-Kettering Division, Kettering Laboratory, Room 316, 
(212) 794-7952 

In this multidisciplinary program, opportunities for advanced study are focused 
on laboratory, clinical and /or statistical research as they relate to cancer pre- 
vention, diagnosis and treatment. Undergraduate prerequisites vary with the 
subspecialty area of training in which the student wishes to concentrate; the 
areas of study offered and their recommended undergraduate backgrounds are 
reviewed briefly below. Graduate Record Examination results in both the apti- 
tude test and the advanced test in an appropriate area of concentration are re- 
quired to be submitted by all applicants to the Unit. 

1. Instruction toward the Ph.D. degree with emphasis in Biochemical and 
Molecular Pharmacology, Medicinal Chemistry and Biochemistry, Clinical 
Chemistry and Biochemistry, Cancer Therapeutics and Toxicology. 

Undergraduate majors in biology, chemistry or health sciences are most 
appropriate backgrounds for admission. In addition, students should have 
adequate training in organic chemistry, physical chemistry, biochemistry and 
physiology. Training in statistics is recommended. 

Course requirements include advanced instruction in cell and molecular 
biology, and courses appropriate to the subspecialty pursued by the student.- 



86 



Other courses might include one or more of the following: Advanced bio- 
chemistry, microscopic anatomy, physiology, neurosciences, biostatistics and 
both general and advanced pharmacology. The program of study designed for 
each student will, in general, reflect the level of the student 's undergraduate 
preparation. 

2. Instruction toward the Ph.D. degree with emphasis in Radiation Biology, 
Radiation Physics, and Radiopharmaceutics. 

Applicants should have a major in biophysics or a major in biology, 
chemistry, or mathematics, with training in general physics, electricity and 
magnetism, mechanics, mathematics (through calculus) and thermodynamics. 

Students will be required to take advanced instruction in cell and molecular 
biology, and in physics, biochemistry and mathematics, depending upon the 
level of prior training. 

Instruction toward the M.S. degree in Radiation Physics is also offered for 
candidates holding a B.A. or B.S. in physics. These candidates are expected to 
take advanced instruction in physics, biophysics, biology, radiobiology, bio- 
chemistry, and biomathematics with a minor in one of these subjects other 
than physics, and prepare a thesis in the field of radiation physics. The candi- 
dates for the M.S. degree must demonstrate a thorough knowledge of this area 
in a final written and oral examination. 

3. Intruction towards the Ph.D. degree in Biostatistics. 

The program is designed to provide training in statistical theory, method- 
ology, and computing, combined with broad experience in data analysis and 
collaborative research with medical investigators. Admission to the program re- 
quires a B.S. degree in mathematical statistics, or the equivalent. 

Courses to be completed by each student will depend upon the level of 
prior training and individual interests. In addition to basic probability theory 
and statistical inference, there is special emphasis on the design and analysis of 
clinical trials and the development of skills in exploratory data analysis. Each 
student participates in an internship program in statistical consulting and col- 
laborative research. A doctoral dissertation in biostatistics involves the develop- 
ment of new theory or methodology under the direction of a faculty advisor. 

Courses 

General Pharmacology (see Field of Pharmacology). 

Advanced Pharmacology (see Field of Pharmacology). 

Radiation Physics, Lectures and Problems A series of lectures and assigned 
problems in applied mathematics, fundamentals of radiation physics, x-ray 
and radium treatment planning, diagnostic x-ray principles, radiation protec- 
tion, and uses of radioactive isotopes. First, second, and third trimesters. 
Dr. Laughlin. 



Biostatistics I: Introduction to Statistical Reasoning It is the aim of this course 
to help participants gain some insight into the theory underlying a probabilistic 
approach to the treatment of observational or experimental data, and to 
acquaint them with the most basic techniques of statistical analysis. First 
trimester. Dr. Groshen. 

Biostatistics II: Experimental Design and Curve Fitting Application of con- 
cepts introduced in Biostatistics I to the analysis of scientific data. Topics include 
statistical design of experiments, analysis of variance, correlation, and linear 
regression. Second trimester. Drs. Groshen and Thaler. 

Survival Analysis and Clinical Trials Parametric and nonparametric models of 
survival times, exponential and Weibull distributions; life-table and Kaplan- 
Meier estimates: design of randomized clinical trials, concomitant variables, 
stratification, sample size determination; 2- and k-sample techniques for cen- 
sored data; generalized Wilcoxon and log-rank tests, Cox regression. Third 
trimester. Dr. Groshen. 

Other Academic Offerings 

Advanced Biophysics Laboratory rotations in various areas of radiation physics. 
Hours by arrangement. Dr. Laughlin. 

Radiobiology Tutorial in fundamental radiobiology dealing with the effects 
of radiation on cells, viruses, and macromolecules, as well as on whole animals. 
Also covered are areas in radiation physics and radiation chemistry pertinent to 
radiobiology. Dr. Zeitz and staff. 

Radiopharmaceutical Chemistry A tutorial in radiopharmaceutical chemistry 
is offered to those students majoring or minoring in this subject. Hours by 
arrangement. Dr. Gelbard and staff. 

Biophysics Colloquia Reports on research in progress by faculty and outside 
lecturers. Required for majors in biophysics. Hours by arrangement. Staff. 



Unit of Immunobiology 

Program Chairman 

O. Stutman. Sloan-Kettering Institute, Kettering Laboratory, Room 1118, 

(212) 794-7475 

Unit Chairman 

B. Dupont, Sloan-Kettering Institute, Schwartz Building, Room 711, 

(212) 794-6005 



88 



Programs arc determined individually on the basis of interest, training, prior 
experience, and consultation with the student's Special Committee. The Unit 
has no fixed course work requirements other than those set by the student's 
permanent Special Committee. However, all students majoring in the program 
are expected to take full advantage of the Unit's core program of formal courses 
as well as to participate in additional course offerings of the Sloan-Kettering 
Division, Medical College Division, and other institutions which best comple- 
ment their previous background and fulfill their scholastic objectives. Students 
will spend their first year in: 1) satisfying course and seminar requirements; 
2) participating in laboratory rotations; and 3) initiating one or two minor 
projects. The Unit Chairman will serve as temporary major advisor during this 
time. At the end of the first year, the student's performance will be reviewed 
and a Special Committee of three members will be selected. The Special 
Committee membership will provide multidisciplinary academic backgrounds. 
During the second academic year, students should complete any minor projects 
required by the Special Committee, take the Admission to Doctoral Candidacy 
Examination, and initiate a thesis project. It is the clear intention of the Unit 
that extensive formal course work should not interfere with participation in 
the various other activities, such as rotations, tutorials and minicourses as well 
as seminars and lectures offered at Sloan-Kettering Institute and neighboring 
institutions. 

Undergraduate prerequisites include a general college-level background in 
biology and other sciences, including a strong background in genetics, bio- 
chemistry and microbiology. 

Submission of Graduate Record Examination results, in both aptitude 
and the advanced test in biology or chemistry, is required. 

Courses 

Immunology I This course is appropriate for, but not restricted to, students 
who have had no formal training in immunology, or who wish to review 
fundamentals in preparation for the advanced course. Immunology II. An over- 
view of specific and non-specific immunity, cellular participants in immune 
response, structure of immunoglobulins and cell surface receptors, molecular 
basis of antibody diversity and cell-surface antigens, specificity of immune 
responses, methods for measuring humoral immune response, immunogenetics 
and transplantation immunology, and methods for measuring cell-mediated 
immune responses are among the topics which will be discussed. First trimester. 
Dr. Dupont 

Immunology II Lectures, discussions and assigned readings for in-depth 
studies to cover properties of antigens and antibodies; mechanism of antibody 
formation; structural and functional aspects of the immune system, molecular 
basis of antibody and lymphocyte diversity; major histocompatibility complexes 



in man and animals; immunogenetics of differentiation ; effector mechanisms 
of antibody and cell-mediated immunity; immuno-deficiency disease; regula- 
tion and control of the immune response; immunological tolerance; immu- 
nology of transplantation, tumor immunology. Prerequisites for the course are 
at least one semester or equivalent of biochemistry and introductory immu- 
nology (Immunology I.) Second trimester. Dr. Lloyd. 

Immunology III Lectures, discussion and assigned readings on subjects related 
to clinical immunology such as histocompatibility antigens; properties of T, 
B lymphocytes, and macrophages; lymphoid cell lines; immunopathology; 
immunodeficiencies; immunogenetics; organ and bone marrow transplanta- 
tion; tumor immunology, etc. Prerequisites are introductory immunology 
(Immunology I) or equivalent course. Third trimester. Dr. Dupont and staff. 

Other Academic Offerings 

Colloquia In Immunology Informal sessions between students and senior 
faculty members to acquaint students with the major research programs headed 
by each of the faculty members of the Immunology Unit. Students from other 
units are also welcome to these sessions, which are announced monthly. The 
colloquia are open to all graduate students at all levels of training. 

Laboratory Rotations, Tutorials and Minicourses In order to become familiar 
with the various research programs which are available to students doing major 
or minor work in immunology, the Unit advises entering students to participate 
in as many laboratory rotations, tutorials and minicourses as can be accom- 
modated into the first-year schedule. The lists and decriptions for laboratory 
rotations, tutorial programs and minicourses are available from the office of 
the Unit Chairperson. 



Unit of Molecular Biology and Virology 
Program Chairman 

R.M. Krug, Sloan-Kettering Institute, Kettering Laboratory, Room 406A, 
(212) 794-7475 

Unit Chairman 

K.J. Marians, Sloan Kettering Institute, Kettering Laboratory, Room 820A, 
(212) 794-5890 

A good background in genetics, chemistry and biochemistry is required of 
students. Graduate Record Examination scores in both the aptitude test and 
the advanced test in biology or chemistry are also required. In the first two 



90 



years students are expected to complete a core curriculum that covers Graduate 
Biochemistry, Cell Biology, Immunology, Genetics, Molecular Virology, 
Molecular Biology and Gene Expression. All students are also required to take 
three seminars or advanced courses. 

Courses 

Molecular Biology The course presents the fundamentals of eukaryote gene 
structure, expression and regulation. Topics discussed include: DNA sequence 
organization, chromatin structure, viral and cellular RNA transcription, trans- 
lation and its regulation, control of gene expression in model systems and 
molecular aspects of carcinogenesis. First, second and third trimesters. Dr. Sen. 

Molecular Virology A formal course in which major emphasis is placed on 
the basic mechanisms in the biology of all animal viruses, including RNA and 
DNA tumor viruses. The topics considered include virus structure and compo- 
sition, assay of viruses and viral-specific products, transcription and replication 
of viral nucleic acids, translation of virus-specific proteins, assembly of viral 
panicles, structural and functional alterations in viral-infected cells including 
transformation, pathogenesis of viral diseases, and viral genetics. Alternate 
years. Dr. Krug. Not offered in 1984-85. 

Molecular Biology of Neoplastic Transformation This course will focus on 
current efforts to understand the neoplastic cell phenotype from a molecular 
point of view. The effects of RNA and DNA tumor viruses on host cells will 
be discussed, in particular the transformation and /or differentiation blocks of 
defined cell lineages by certain agents. The nature and enzymatic specificities 
of viral gene products responsible for transformation will be compared with 
related products of normal cellular genes. The potential interaction of such 
products with regulatory systems controlling cell shape, adhesiveness, motility, 
and mitosis will be described, as well as the possible involvement of the same 
systems in nonviral neoplasias. At least pan of the course will consist of stu- 
dent presentations on relevant subjects. Alternate years. Third trimester. 
Drs. Fleissner, Besmer, Hayward, and staff. 

Advanced Nucleic Acids Enzymology. A formal course presenting the en- 
zymological mechanisms and control of prokaryotic and eukaryotic transcription 
and DNA replication. Enzymes which alter DNA structure and shape are re- 
viewed and topics in DNA repair and recombination are also covered. Graduate 
Biochemistry is a prerequisite. Third trimester. Drs. Marians and Hurwitz. 



91 



Register 



93 



University Administration 

Frank H.T. Rhodes, President of the University 

Robert Barker, University Provost 

Thomas H. Mciklc.Jr., Provost for Medical 

Affairs and Dean of the Medical College 

William G. Herbster, Senior Vice President 

Joseph M Ballantyne, Vice President for 
Research and Advanced Studies 

David L. Call, Vice President for State, 
Federal and Public Relations 

William D Gurowitz, Vice President for 
Campus Affairs 

Robert M. Matyas, Vice President for Facilities 
and Business Operations 

Richard M Ramin, Vice President for Public 
Affairs 

James A. Sanderson, Chief Investment Officer 

Joan R. Egner, Associate Provost 

Kenneth M King, Vice Provost 

James W Spencer, Vice Provost 

Walter J. Relihan, Jr., University Counsel and 
Secretary of the Corporation 

Graduate School of 
Medical Sciences 

Administration 

Frank H .T. Rhodes, President of the University 

Alison P. Casarett, Dean of the Graduate 
School 

Bernard L. Horecker. Dean of the Graduate 
School of Medical Sciences, Associate 
Dean of the Graduate School 

Dieter H. Sussdorf, Associate Dean of the 
Graduate School of Medical Sciences, 
Assistant Dean of the Graduate School 

Richard A. Rifkind, Director, Sloan-Kettering 
Division 

Dorris J. Hutchison, Associate Director, Sloan- 
Kettering Division; Associate Dean of 
the Graduate School of Medical Sciences. 
Assistant Dean of the Graduate School 



Faculty 

Alcock, Nancy W., Assistant Professor of 
Developmental Therapy and Clinical 
Investigation. B.S. 1949, University of 
Tasmania (Australia); Ph.D. I960, 
University of London (England) 

Allen, Fred H. Jr., Clinical Associate Professor 
of Pediatrics, A.B. 1934, Amherst 
College; M.D. 1938, Harvard University 

Allfrey, Vincent G., Adjunct Professor of 
Genetics, B.S. 1943, City College of 
New York; M.S. 1948, Ph.D. 1949. 
Columbia University 

Alonso, Daniel R., Associate Professor of 
Pathology. M.D. 1962, University of 
Cuyo (Argentina) 

Andersen. Olaf S., Professor of Physiology and 
Biophysics. Candidatus Medicinae 1971, 
University of Copenhagen (Denmark) 

Anderson, Lowell L.. Assistant Professor of 
Developmental Therapy and Clinical 
Investigation. B.S. 1953, Whitworth 
College; Ph.D. 1958, University of 
Rochester 

Artzt, Karen, Associate Professor of Cell 

Biology & Genetics. A.B. 1964, Ph.D. 
1972, Cornell University 

Bachvarova, Rosemary F., Associate Professor 
of Cell Biology and Anatomy. B.A. 
1961, Radcliffe College; Ph.D., 1966, 
Rockefeller University 

Bader. David M., Assistant Professor of Cell 
Bioiogy and Anatomy. B.A. 1974, 
Augustana College; Ph.D. 1978, 
University of North Dakota 

Baker, Harriet D., Assistant Professor of 

Neurology. B.A. 1963, Wells College; 
M.S. 1967, University of Illinois; Ph.D. 
1976, University of Iowa 

Balis, M. Earl, Professor of Cell Biology and 
Genetics. B.A. 1943, Temple University; 
Ph.D. 1949, University of Pennsylvania 

Bancroft, F. Carter, Associate Professor of 
Molecular Biology and Virology. B.S. 
1959, Antioch College; M.A. 1961, 
Johns Hopkins University; Ph.D. 1966, 
University of California at Berkeley 



95 



Bank, Arthur, Adjunct Professor of Cell 
Biology and Anatomy. B.A. 1956, 
Columbia University; M.D. 1960, 
Harvard University Medical School 

Barany, Francis, Assistant Professor of Micro- 
biology. B.A. 1976, University of Illinois 
at Chicago Circle; Ph.D. 1981, 
Rockefeller University 

Becker, Carl G., Professor of Pathology. B.S. 
1957, Yale University; M.D. 1971, 
Cornell University 

Bedford, J. Michael, Professor of Cell Biology 
and Anatomy. B.A. 1955, M.A. Vet. 
M.B. 1958, Cambridge University 
(England); Ph.D. 1965, University of 
London (England) 

Bennett, Dorothea, Professor of Cell Biology 
and Genetics. A.B. 1951, Barnard Col- 
lege; Ph.D. 1956, Columbia University 

Berns, Kenneth I. , R. A. Rees Pritchett Professor 
of Microbiology. A.B. I960, Ph.D. 1964, 
M.D. 1966, Johns Hopkins University 

Besmer, Peter, Assistant Professor of Molecular 
Biology and Virology. M.S. 1964; 
Ph.D. 1969, Eidgenbssische Technische 
Hochschule (Switzerland) 

Bianco, Celso, Adjunct Professor of Cell 

Biology and Anatomy. M.D. 1966, Escola 
Paulista de Medicina (Sao Paulo, Brazil) 

Biedler, June L., Professor of Cell Biology and 
Genetics. A.B. 1947, Vassar College; 
Ph.D. 1959, Cornell University 

Black, Ira B., Professor of Neurology. A.B. 
1961, Columbia College; M.D. 1965, 
Harvard University 

Blass, John P. , Professor of Neurology and 
Medicine, A.B. 1958, Harvard 
University, Ph.D. I960, University of 
London (England), M.D. 1965, 
Columbia University 

Bockman, Richard S., Assistant Professor of 
Cell Biology and Genetics. B.A. 1962, 
Johns Hopkins University; M.D. 1967, 
Yale University; Ph.D. 1971, Rockefeller 
University 

Borenfreund, Ellen, Associate Professor of Cell 
Biology and Genetics. B.S. 1946, 
Hunter College; Ph.D. 1957, New York 
University 



Boskey, Adele L., Associate Professor of Bio- 
chemistry. B.A. 1964, Barnard College; 
Ph.D. 1970, Brown University 

Boyse, Edward A., Professor of Immunobiology. 
M.B. B.S. 1952, M.D. 1957, University 
of London (England) 

Breslow, Esther M., Professor of Biochemistry. 
B.S. 1953, Cornell University; M.S. 
1955, Ph.D. 1959, New York University 

Briscoe, William A., Professor of Medicine. 

B.A. 1939, M.A. 1941, B. M.B. Ch. 1942, 
D M. 1951, Oxford University (England) 

Brooks, Dana C, Professor of Cell Biology 

and Anatomy. B.E.E. 1949, M.D. 1957, 
Cornell University 

Bullough, Peter, Associate Professor of Pathol- 
ogy. M.D. 1956, Liverpool University 
(England) 

Cavalieri, Liebe F., Professor of Molecular 

Biology and Virology. B.S. 1943, Ph.D. 
1945, University of Pennsylvania 

Cayre, Yvon, Assistant Professor of Immuno- 
biology. M.D. 1972, Montpellier Faculty 
of Medicine (France); Dr. Sci. 1978, 
Paris Faculty of Science (France) 

Chaganti, Raju S., Associate Professor of Cell 
Biology and Genetics. B.S. 1954, M.S. 
1955, Andhra University (India); Ph.D. 

1964, Harvard University 

Chan, Walter W.Y, Professor of Pharmacology. 
B.A. 1956, University of Wisconsin; 
Ph.D. 1961, Columbia University 

Chao, Moses V., Assistant Professor of Cell 
Biology and Anatomy. B.A. 1973, 
Pomona College; Ph.D. 1980, University 
of California at Los Angeles 

Chen-Kiang, Selina Y., Assistant Professor of 
Molecular Biology and Virology. B.S. 

1965, National Taiwan University; 
Ph.D. 1977, Columbia University 

Choi, Yong Sung, Professor of immunobiology. 
M.D. 1961, Seoul National University 
(Korea); M.S., Ph.D. 1965, University 
of Minnesota 

Chou, Ting-Chao, Associate Professor of 

Developmental Therapy and Clinical 
Investigation. B.S. 1961, Kaohsiung 
Medical College (Taiwan); M.S. 1965, 
National Taiwan University; Ph.D. 
1970, Yale University 



96 



Cooper, Arthur J.L., Associate Professor of 

Biochemistry in Neurology. B.Sc. 1967, 
M.Sc. 1969, University of London 
(England); Ph D 1974, Cornell 
Universiu 

Cunningham-Rundlcs, Charlotte, Assistant 

Professor of lmmunobiology. B.S. 1965, 
Duke University, M.D. 1969, Columbia 
College of Physicians and Surgeons; 
Ph D. 1974, New York University 

Danes. B Shannon, Associate Professor of 
Medicine. B.A. 1948, Mount Holyokc 
College; MA. 1949, University of Texas; 
Ph D. 1952, State University of Iowa; 
M.D. 1962, Columbia University 

Darzynkicwicz. Zbignicw, Associate Professor 
of Cell Biology and Genetics. M .D. I960, 
Academy of Medicine, Warsaw (Poland); 
Ph.D. 1965, Academy of Medicine and 
Polish Academy of Sciences (Poland) 

Deschner, Eleanor E., Assistant Professor of 
Cell Biology and Genetics B.A. 1949, 
Notre Dame of Statcn Island; M.S. 
1951, Ph.D. 1954, Fordham University 

Dickerman. Robert W., Associate Professor of 
Microbiology. B.S. 1951, Cornell 
University; M.A. 1953, University of 
Arizona; Ph.D. 1961, University of 
Minnesota 

Donner. David B , Associate Professor of Cell 
Biology and Genetics. B.A. 1966, 
Queens College; Ph.D. 1972, 
Rensselaer Polytechnic Institute 

Dreyfus, Cheryl F., Assistant Professor of 
Neurology. B.S. 1967, University of 
Vermont; M.S. 1969. Ph.D. 1976. 
Cornell University 

Dupont. Bo, Professor of lmmunobiology. 
M.D. 1966, University of Arhus 
(Denmark) 

Eisinger. Magdalcna G., Assistant Professor of 
Cell Biology and Genetics. D.V.M. 
1962. Agricultural University Kosice 
(Czechoslovakia) 

Ellis, John T , Professor of Pathology. B.A. 
1942, University of Texas; M.D. 1945, 
Northwestern University 

Evans, Robert L., Assistant Professor of 

lmmunobiology. M.D. 1972, University 
of Washington 



Fairclough, Gordon F., Associate Professor of 
Biochemistry. B.A. 1960, Ph.D. 1966, 
Yale University 

Famulari, Nancy G., Assistant Professor of 
Molecular Biology and Virology. B.A. 
1969, Colby College; Ph.D. 1974. 
Cornell University 

Fell, Colin, Associate Professor of Physiology 
and Biophysics. B.A. 1951. Antioch 
College; M.S. 1953. Ph.D. 1957, 
Wayne State University 

Felscn. Diane F., Assistant Professor of Pharma- 
cology in Surgery. B.A. 1974, Queens 
College; Ph.D. 1979, Mt. Sinai School 
of Medicine 

Fischman, Donald A., Professor of Cell Biology 
and Anatomy Harvey Klein Professor 
of Biomedical Sciences. A.B. 1957, 
Kenyon College; M.D. 1961, Cornell 
University 

Flcisher. Martin, Assistant Professor of Devel- 
opmental Therapy and Clinical Investi- 
gation. B.A. 1958, Harpur College; 
Ph.D. 1966, New York University 

Fleissner, Erwin, Professor of Molecular 

Biology and Virology. B.A. 1957, Yale 
University; Ph.D. 1963, Columbia 
University 

Fogh.Jorgen E., Associate Professor of Cell 
Biology and Genetics. M.D. 1949, 
University of Copenhagen (Denmark) 

Fox, Jack J., Professor of Developmental 

Therapy and Clinical Investigation. A.B. 
1939, Ph.D. 1950, University of Colorado 

Fried, Jerrold. Associate Professor of Develop- 
mental Therapy and Clinical Investiga- 
tion. B.S. 1958, California Institute of 
Technology; Ph.D. 1964, Stanford 
University 

Friedman, Eileen A., Assistant Professor of 
Cell Biology and Genetics. A.B. 1967, 
New York University; Ph.D. 1972, 
Johns Hopkins University 

Frindt. Gustavo. Research Associate Professor 
of Physiology and Biophysics. M.D. 
1963. Catholic University of Chile 

Furth, Mark E.. Assistant Professor of Molec ular 
Biology and Virology. B.A. 1972, 
Harvard University; Ph.D. 1978, 
University of Wisconsin-Madison 



o- 



Gardner, Daniel, Associate Professor of 

Physiology and Biophysics. A.B. 1966, 
Columbia College; Ph.D. 1971, New 
York University 

Gass.Jerald D., Associate Professor of Bio- 
chemistry. B.S. 1957, University of 
Oklahoma; A.M. 1962, Harvard Univer- 
sity; Ph.D. 1969, Cornell University 

Gazzaniga, Michael S., Professor of Neuro- 
psychology in Neurology. A.B. 1961, 
Dartmouth College; Ph.D. 1964, 
California Institute of Technology 

Gelbard, Allan S., Associate Professor of 
Developmental Therapy and Clinical 
Investigation. B.S. 1955, Brooklyn 
College; M.S. 1956, University of 
Massachusetts; Ph.D. 1959, University 
of Wisconsin 

Geller, Nancy L., Assistant Professor of 

Developmental Therapy and Clinical 
Investigation. B.S. 1965, City 
University of New York; M.A. 1967, 
Case Institute of Technology; Ph.D. 
1972, Case Western Reserve University 

German, James L. Ill, Clinical Professor of 
Pediatrics; Clinical Professor of 
Medicine. B.S. 1945, Louisiana 
Polytechnic Institute; M.D. 1949, 
Southwestern Medical College 

Gershengorn, Marvin C, Professor of 

Physiology and Biophysics. B.S. 1967, 
City College of the City University of 
New York; M.D. 1971, New York 
University School of Medicine. 

Gibbs, James G. Jr., Associate Professor of 
Psychiatry. B.S. I960, Trinity College; 
M.D. 1964, Medical College of South 
Carolina 

Gibson, Gary E., Associate Professor of 

Neurology. B.S. 1968, University of 
Wyoming; Ph.D. 1973, Cornell 
University 

Gilder, Helena, Associate Professor of Bio- 
chemistry in Surgery; Assistant Professor 
of Biochemistry. A.B. 1935, Vassar 
College; M.D. 1940, Cornell University 

Girgis, Fakhry, Associate Professor of Cell 

Biology and Anatomy. M.B.B.Ch. 1949, 
Cairo University (Egypt); Ph.D. 1957, 
Queen's University (Northern Ireland) 



Goldstein, Jack, Associate Professor of Bio- 
chemistry. B.A. 1952, Brooklyn College; 
M.N.S. 1957, Ph.D. 1959, Cornell 
University 

Graf, Lloyd H.Jr., Assistant Professor of 

Genetics in Obstetrics and Gynecology. 
B.S. 1967, Ph.D. 1972, Duke University 

Grafstein, Bernice, Professor of Physiology and 
Biophysics. B.A. 1951, University of 
Toronto (Canada); Ph.D. 1954, McGill 
University Canada) 

Greif , Roger L. , Emeritus Professor of 

Physiology and Biophysics. B.S. 1937, 
Haverford College; M.D. 1941, Johns 
Hopkins University 

Griffith, Owen W., Associate Professor of 

Biochemistry. B.A. 1968, University of 
California at Berkeley; Ph.D. 1976, 
Rockefeller University 

Groshen, Susan, Assistant Professor of 

Developmental Thetapy and Clinical 
Investigation. A.B. 1973, Cornell 
University; M.S. 1976, Ph.D. 1978, 
Rutgers University 

Gupta, Sohan Lai, Assistant Professor of 

Molecular Biology and Virology. M.S. 
1960, Aligarh Muslim University 
(India); Ph.D. 1967, All India Institute 
of Medical Sciences, New Delhi (India) 

Hadden, John W., Adjunct Professor of 
Immunobiology. B.A. 1961, Yale 
University; M.D. 1965, Columbia 
University 

Hagamen, Wilbur D., Professor of Cell Biology 
and Anatomy. B.S. 1945, Baldwin- 
Wallace College; M.D. 1951, Cornell 
University 

Hajjar, David, Associate Professor of Pathology. 
B.A. 1974, American International 
College; M.S. 1977, Ph.D. 1978, 
University of New Hampshire 

Halmi, Katherine A., Associate Professor of 
Psychiatry. B.A. 1961, M.D. 1965, 
University of Iowa 

Hammerling, Ulrich, Professor of Immuno- 
biology. Diplom 1961 Universitat 
Freiburg (Germany); Ph.D. 1965, Max 
Planck Institut fur Immunobiologie 
(Germany) 



9S 



Hardy. William D.Jr., Assistant Professor of 
Molecular Biology and Virology. A. A. 
1969, B.S. 1962. George Washington 
University; V.M.D. 1966, University of 
Pennsylvania 

Haschcmeyer, Rudy H . Professor of Bio- 
chemistry. B.A. 1952, Carthage College; 
Ph.D. 1957. University of Illinois 

Hayward, William S., Professor of Molecular 
Biology and Virology. B.A. 1964, Uni- 
versity of California, Riverside; Ph.D. 
1969, University of California, San Diego 

Higgins, Paul J., Assistant Professor of Cell 
Biology and Genetics. B.S. 1969, Iona 
College; M.S. 1973, Long Island Univer- 
sity; Ph.D. 1976, New York University 

Hinkle, Lawrence E.Jr.. Professor of Medicine; 
Professor of Medicine in Psychiatry. 
B.A. 1938, University of North Carolina; 
M.D. 1942, Harvard University 

Hinman, Donald J., Assistant Professor of 
Pharmacology. B.S. 1970, M.S. 1972, 
Iowa State University; Ph.D. 1976, 
Stritch School of Medicine at Loyola 
University 

Hoffman, Hans-Peter. Adjunct Assistant 
Professor of Genetics. B.A. 1968, 
Ph.D. 1973, Rutgers University 

Hoffman. Michael K., Associate Professor of 
Immunobiology. M.D. 1966, Universitat 
Tubingen (Germany) 

Horecker, Bernard L., Professor of Bio- 
chemistry. B.S. 1936. Ph.D. 1939, 
University of Chicago 

Hoscin, Barbara H . Adjunct Assistant 

Professor of Cell Biology and Anatomy. 
B.A. 1969, University of Kansas; M.S. 
1971, Ph.D. 1973. University of 
Michigan 

Houdc. Raymond W., Professor of Pharma- 
cology; Professor of Developmental 
Therapy and Clinical Investigation. 
A.B. 1940, M.D. 1953. New York 
University 

Hurwitz, Jerard, Professor of Molecular Biology 
and Virology. B.A. 1949. Indiana 
University; Ph.D. 1953. Western 
Reserve University 



Huuhison, Dorris J.. Professor of Cell Biology 
and Genetics. B.S. 1940, Western 
Kentucky State College; M.S. 1943, 
University of Kentucky ; Ph.D. 1949, 
Rutgers University 

Incefy, Genevieve S.. Assistant Professor of 
Immunobiology. B.Sc. 1959, M.Sc. 
1960, Ph.D. 1964, Ohio State University 

[fltutrisi, Charles E., Professor of Pharma- 
cology. B.S. 1962, University of 
Connecticut; M.S. 1965; Ph.D. 1967, 
Tulanc University 

Javitt , Norman B.. Professor of Medicine. 

A. B. 1947, Syracuse University; Ph.D. 
1951, University of North Carolina; 
M.D. 1954, Duke University 

Joh, Tong Hyub, Professor of Neurobiology in 
Neurology. B.S. 1953, Seoul National 
University (Korea); Ph.D. 1971, New 
York University 

Johnson, Edward M . Adjunct Assistant Pro- 
fessor of Genetics. B.A. 1967, Pomona 
College, Ph.D. 1971, Yale University 

Jones, Thomas Clifford, Professor of Medicine 

B. A. 1958. Allegheny College; M.D 

1962, Case Western Reserve University 

Kaiko, Robert F., Assistant Professor of 

Pharmacology. B.S. 1970, University of 
Connecticut; Ph.D. 1974, Cornell 
University 

Kaplan, Barry B., Adjunct Associate Professor 
of Cell Biology and Anatomy. B.A. 
1968, M.A. 1969, Hofstra University; 
Ph.D. 1974, Cornell University 

Kcithly.Jan S., Assistant Professor of Micro- 
biology; Assistant Professor of Micro- 
biology in Medicine. B.S. 1963, Central 
Missouri State University; Ph.D. 1968, 
Iowa State University 

Kellner, Aaron, Clinical Professor of Pathology. 
B.A. 1934, Yeshiva College; M.S. 1936, 
Columbia University; M.D. 1939. 
University of Chicago 

Kim.Jae Ho, Associate Professor of Develop- 
mental Therapy and Clinical Investiga- 
tion. M.D. 1959. Kyungpook National 
School of Medicine (Korea); Ph D 

1963. State University of Iowa 



99 



Koo, Gloria C, Assistant Professor of Immuno- 
biology. B.A. 1965, Goshen College; 
Ph.D. 1970, Temple University 

Kourides, lone A., Associate Professor of Cell 
Biology and Genetics. B.A. 1963, 
Wellesley College; M.D. 1967, Harvard 
University 

Krug, Robert M., Professor of Molecular 
Biology and Virology. B.A. 1961, 
Harvard University; Ph.D. 1966, 
Rockefeller University 

Lacy, Elizabeth, Assistant Professor of 

Molecular Biology and Virology. B.A. 
1974, University of Pennsylvania; 
Ph.D. 1980, California Institute of 
Technology 

Lai, Chun-Yen, Adjunct Professor of Bio- 
chemistry. B.S. 1953, M.S. 1957, 
National Taiwan University; Ph.D. 
1961, University of Illinois 

Laughlin, John S., Professor of Developmental 
Therapy and Clinical Investigation. 
A.B. 1940, Willamette University; 
Ph.D. 1947, University of Illinois 

Lee, Chin Ok, Associate Professor of Physiology 
and Biophysics. M.S. 1967, Seoul 
National University (Korea); Ph.D. 

1973, Indiana University School of 
Medicine 

Lee, Janet, Assistant Professor of Immuno- 
biology. B.A. 1972, University of 
Minnesota; M.S. 1974, University of 
Wisconsin; Ph.D. 1979, University of 
California at San Francisco 

Levi, Roberto, Professor of Pharmacology. 

M.D. 1960, University of Florence (Italy) 

Levy, David E., Associate Professor of 

Neurology. A.B. 1963, M.D. 1968, 
Harvard University 

Lin, Chiann-Tso, Assistant Professor of 

Physiology and Biophysics. Diploma of 
Engineering 1963, Taipei Institute of 
Technology ; Diploma of Chemistry 
(Master) 1970, Technical University of 
Braunschweig (West Germany); Ph.D. 

1974, University of Frankfurt (West 
Germany) 

Lipkin, Martin, Professor of Medicine. A.B. 

1946, M.D. 1950, New York University 



Litman, Gary W., Associate Professor of 
Immunobiology. B.A. 1967, Ph.D. 
1972, University of Minnesota 

Lloyd, Kenneth O., Associate Professor of 

Immunobiology. Ph.D. 1960, University 
College of North Wales (England) 

Lockard, Raymond E., Assistant Professor of 
Biochemistry. B.S. 1966, Syracuse 
University; Ph.D. 1972, University of 
Cincinnati 

Lopez, Carlos, Associate Professor of Immuno- 
biology. B.A. 1965, M.S. 1966, Ph.D. 
1970, University of Minnesota 

Maack, Thomas, Professor of Physiology and 
Biophysics. M.D. 1962, University of 
Sao Paulo (Brazil) 

MacLeod, John, Emeritus Professor of Cell 
Biology and Anatomy. A.B. 1934, 
M.Sc. 1937, New York University; 
Ph.D. 1941, Cornell University 

Marians, Kenneth J., Associate Professor of 
Molecular Biology and Virology. B.S. 
1972, Polytechnic Institute of Brooklyn; 
Ph.D. 1976, Cornell University 

Marks, Paul A., Professor of Cell Biology and 
Genetics. A.B. 1945, Columbia Univer- 
sity; M.D. 1949, College of Physicians 
and Surgeons, Columbia University 

Mehta, Bipin M., Assistant Professor of 

Developmental Therapy and Clinical 
Investigation. B.Sc. 1955, M.Sc. 1957, 
Ph.D. 1963, Bombay University (India) 

Meister, Alton, Israel Rogosin Professor of 

Biochemistry. B.S. 1942, Harvard Uni- 
versity; M.D. 1945, Cornell University 

Melamed, Myron R., Professor of Cell Biology 
and Genetics. B.S. 1947, Western 
Reserve University; M.D. 1950, 
University of Cincinnati 

Melera, Peter W., Assistant Professor of 

Molecular Biology and Virology. A.A.S. 
1963, State University of New York at 
Cobleskill; B.S. A. 1965, Ph.D. 1969, 
University of Georgia 

Meshnick, Steven R., Assistant Professor of 

Medicine. B.A. 1972, Columbia Univer- 
sity; Ph.D. 1978, Rockefeller University; 
M.D. 1979, Cornell University 



100 



Minick, C. Richard. Professor of Pathology. 
B.S. 1957, University of Wyoming; 
M.D. 1960, Cornell University 

Modak. MukundJ.. Associate Professor of 
Molecular Biology and Virology. B.Sc. 
1963. University of Poona (India); M.Sc. 
1965, University of Bombay (India); 
Ph.D. 1969, Haffkine Institute. 
University of Bombay (India) 

Moon, Hong Mo. Adjunct Professor of Neuro- 
biology. B.S. 1961, Sung Kyun Kwan 
University (Korea); Ph.D. 1967, 
University of North Carolina 

Moore, Malcolm A S., Professor of Cell Biology 
and Genetics. M B. 1963, B.A. 1964, 
D.Phil. 1967. M A. 1970, Oxford 
University (England) 

Muller-Ebcrhard, Ursula. Professor of Pediatrics; 
Professor of Pharmacology. M.D. 1953, 
University of Gottingen (Germany) 

Nachman. Ralph L., Professor of Medicine. 

A. B. 1953. M.D. 1956, Vanderbilt 
University 

Nachshcn, Daniel A.. Assistant Professor of 
Physiology and Biophysics. B.Sc. 1970, 
Hebrew University. Ph.D. 1979, Sackler 
School of Medicine at Tel Aviv 
University (Israel) 

Nissclbaum, Jerome S., Associate Professor of 
Developmental Therapy and Clinical 
Investigation. B.A. 1949, University of 
Connecticut; Ph D 1953. Tufts 
University 

Novogrodsky, Abraham, Associate Professor of 
Biochemistry. M.D. 1960, Hebrew 
University Medical School, Jerusalem; 
Ph.D. 1974, Weizmann Institute of 
Science. Rehovot (Israel) 

O'Donnell. Paul V.. Assistant Professor of 
Molecular Biology and Virology. B.S. 
1968, Rensselaer Polytechnic Institute; 
Ph.D. 1973, Cornell University 

Oettgen. Herbert F . Professor of Immuno- 
biology. M.D. 1951, University of 
Cologne (Germany) 

Okamoto. Michiko. Professor of Pharmacology. 

B. S. 1954. Tokyo College of Pharmacy 
(Japan); M.S. 1957, Purdue University; 
Ph.D. 1964. Cornell University 



Old, Lloyd J., Professor of Immunobiology. 
B.A. 1955. M.D 1958, University of 
California 

O'Leary. William M., Professor of Micro- 
biology. B.S. 1952, M.S. 1953, Ph.D. 
1957, University of Pittsburgh 

Oliff, Allen I., Assistant Professor of Molecular 
Biology and Virology. B.S. 1971, 
Brandcis University; M.D. 1974, Albert 
Einstein College of Medicine 

O'Reilly, Richard J., Associate Professor of 

Immunobiology. A.B. 1964, College of 
the Holy Cross; M.D. 1968, University 
of Rochester 

Otter, Brian J . Associate Professor of Develop- 
mental Therapy and Clinical Investiga- 
tion. B.Sc. 1962, Ph.D. 1965, 
University of Bristol (England) 

Pahwa. Rajendra N., Assistant Professor of 

Immunobiology. M B. B.S. 1966, M.D. 
1969, Indore Medical College (India) 

Palmer, Lawrence G., Associate Professor of 
Physiology and Biophysics. B.A. 1970, 
Swarthmore College; Ph.D. 1976, 
University of Pennsylvania 

Pardee, Joel D., Assistant Professor of Cell 
Biology and Anatomy. B.S. 1973, 
Colorado State University; Ph.D. 1978, 
Stanford University 

Pasternak, Gavril W., Associate Professor of 
Pharmacology. B.A. 1969, M.D. 1973, 
Ph.D. 1974, Johns Hopkins University 

Pelus, Louis M., Assistant Professor of Cell 
Biology and Genetics. B.A. 1973, 
Queens College of the City University 
of New York; M.S. 1977, Ph.D. 1977, 
Rutgers University 

Petito, Carol K., Associate Professor of 

Pathology. B.S. 1963, Jackson College; 
M.D. 1967, Columbia University 

Phillips, David M., Adjunct Professor of Cell 
Biology and Anatomy. B.S. 1961, 
Northeastern University; Ph.D. 1966, 
University of Chicago 

Pickel, Virginia M., Professor of Neurology. 
B.S. 1965. M.S. 1967, University of 
Tennessee; Ph.D. 1970, Vanderbilt 
University 



101 



Pickering, Thomas G., Associate Professor of 
Medicine. B.A. 1962, M A. 1968, 
Cambridge University (England); Ph.D. 
1970, Oxford University (England) 

Pinter, Abraham, Assistant Professor of 

Molecular Biology and Virology. B.Sc. 
1969, Brooklyn College; PhD! 1973, 
Columbia University 

Platsoukas, Chris D., Assistant Professor of 
Immunobiology. B.S. 1973, University 
of Patras (Greece); Ph.D. 1978, 
Massachusetts Institute of Technology 

Plum, Fred, Anne Parrish Titzell Professor of 
Neurology. B.A. 1944, Dartmouth 
College; M.D. 1947, Cornell University 

Pollack, Marilyn S., Adjunct Assistant Pro- 
fessor of Immunobiology. A.B. 1961, 
M.A. 1963, University of California at 
Berkeley; Ph.D. 1968, Rutgers University 

Polley, Margaret J., Associate Research Pro- 
fessor of Medicine. B.S. 1953, University 
of Wales; Ph.D. 1964, University of 
London (England) 

Posner, Aaron S., Professor of Biochemistry. 
B.S. 1941, Rutgers University; M.S. 
1949, Polytechnic Institute of Brooklyn; 
Ph.D. 1954, University of Liege 
(Belgium) 

Prince, Alfred M., Clinical Associate Professor 
of Pathology. A.B. 1949, Yale Univer- 
sity; M.A. 1951, Columbia University; 
M.D. 1955, Western Reserve University 

Rabellino, Enrique M., Assistant Professor of 
Medicine. B.S. 1959, Institute J. M. Paz 
(Argentina); M.D. 1965, University of 
Cordoba (Argentina) 

Rachele, Julian R., Emeritus Professor of 

Biochemistry. B.A. 1934, M.S. 1935, 
Ph.D. 1939, New York University 

Ralph, Peter M., Adjunct Associate Professor 
of Cell Biology and Genetics. B.A. 1958, 
Yale University, M.A. I960, University 
of California at Berkeley; Ph.D. 1968, 
Massachusetts Institute of Technology 

Ravetch, Jeffrey A., Assistant Professor of 
Molecular Biology and Virology. B.S. 
1973, Yale University; Ph.D. 1978, 
Rockefeller University; M.D. 1979, 
Cornell University 



Rayson, Barbara, Assistant Professor of 

Physiology and Biophysics; Assistant 
Professor of Medicine in Physiology. 
B.Sc. 1972, Ph.D. 1976, University of 
Melbourne (Australia) 

Reidenberg, Marcus M., Professor of Pharma- 
cology. B.S. 1954, Cornell University; 
M.D. 1958, Temple University 

Reis, Donald J., George C. Cotzias Distin- 
guished Professor of Neurology. A.B. 
1953, M.D. 1956, Cornell University 

Rifkind, Arleen B., Professor of Pharmacology; 
Associate Professor of Medicine. B.A. 

1960, Bryn Mawr College; M.D. 1964, 
New York University 

Rifkind, Richard A., Professor of Cell Biology 
and Genetics. B.S. 1962, Yale Univer- 
sity; M.D. 1955, Columbia University 

Riggio, Robert, Professor of Biochemistry. 

B.A. 1954, Dartmouth College; M.D. 

1958, New York University 

Riker, Walter F. Jr. , Professor of Pharmacology. 
B.S. 1939, Columbia University; M.D. 
1943, Cornell University 

Rjsley, Michael, Assistant Professor of Cell 
Biology and Anatomy. B.S. 1970, 
Manhattan College; Ph.D. 1976, City 
University of New York 

Roberts, Joseph, Associate Professor of 

Developmental Therapy and Clinical 
Investigation. B.Sc. 1959, University of 
Toronto (Canada); M.S. 1962, University 
of Wisconsin; Ph.D. 1964, McGill 
University (Canada) 

Roberts, Richard B., Professor of Medicine. 
B.A. 1955, Dartmouth College; M.D. 

1959, Temple University 

Rodman, Toby C, Professor of Cell Biology 
and Anatomy. B.S. 1937, Philadelphia 
College of Pharmacy and Science; M.S. 

1961, Ph.D. 1963, New York University 

Rodriguez-Boulan, Enrique, Associate Professor 
of Cell Biology and Anatomy. B.A. 
1963, National College of Buenos Aires; 
M.D. 1970, University of Buenos Aires 

Rosen, Ora M., Professor of Molecular Biology 
and Virology. B.A. 1956, Barnard 
College; M .D. 1960, Columbia University 



102 



Rosenberg, Barbara. Associate Professor of 
Molecular Biology and Virology. B.S. 
1950. Ph.D. 1962, Cornell University 

Rottenberg, David A., Associate Professor of 
Neurology B.A. 1963, University of 
Michigan; M.Sc. 1967, University of 
Cambridge (England); M.D. 1969, 
Harvard University 

Rubin. Albert L., Professor of Biochemistry in 
Surgery. M.D. 1950, Cornell University 

Rubenstein, Pablo. Adjunct Associate Professor 
of Genetics. Ph.D. 1964, Universidad 
de Chile 

Ruggiero, David A., Assistant Professor of 

Neurobiology in Neurology. B.A. 1972, 
Queens College of the City University 
of New York, M A. 1976. M.Phil. 1977, 
Ph.D. 1977, Columbia University 

Sackin, Henry J., Assistant Professor of 

Physiology and Biophysics. B.S., B.A. 
1970, M.S. 1971, Brown University; 
Ph.D. 1978, Yale University 

Safai. Bijan, Assistant Professor of Immuno- 
biology. M.D. 1965, University of 
Teheran Medical School (Iran) 

Santos-Buch, Charles A., Professor of Pathology. 
A.B. 1953, Harvard University; M.D. 
1957, Cornell University 

Sarkar, Nurul H., Associate Professor of 

Molecular Biology and Virology. B.S. 
1957, M.S. 1960, Ph.D. 1966, 
University of Calcutta (India) 

Saxena, Bnj B., Professor of Endocrinology in 
Obstetrics and Gynecology. Ph D 
1954, University of Lucknow (India); 
D.Sc. 1957, University of Munster 
(Germany); Ph.D. 1961, University of 
Wisconsin 

Scheid, Margrit P., Associate Professor 
of Immunobiology. M.D. 1970, 
Physiologisches Institut der Frcicn 
Universitat Berlin (Germany) 

Schneider, Allan S., Associate Professor of Cell 
Biology and Genetics. B.Ch.E. 1961, 
Rensselaer Polytechnic Institute; M.S. 
1963. Pennsylvania State University; 
Ph D 1968. University of California at 
Berkeley 



Schubert, Edward T., Assistant Professor of Bio- 
chemistry in Pediatrics. B.S. 1949, M.S. 
1952. Ph.D. 1959. Fordham University 

Schwartz, Morton K.. Professor of Develop- 
mental Therapy and Clinical Investiga- 
tion. B.A. 1948, Lehigh University; 
Ph.D. 1952, Boston University 

Sechzer.Jeri A., Associate Professor of 

Psychology in Psychiatry. B.S. 1956, 
New York University; M A. 1961, 
Ph.D. 1962, University of Pennsylvania 

Sen, Ganes C, Assistant Professor of Molecular 
Biology and Virology. B.S. 1965, M.S. 
1967, Calcutta University (India); Ph.D. 
1974, McMastcr University (Canada) 

Senterfit. Laurence B.. Professor of Micro- 
biology. B.S. 1949. M.S. 1950, Univer- 
sity of Florida; Sc.D. 1955, Johns 
Hopkins University 

Shapiro. Joan Rankin, Assistant Professor of 
Cell Biology in Neurology. B.S. 1960. 
Westminster College; M.S. 1968. New 
York University; M A. 1970, Hofstra 
University; Ph.D. 1979, Cornell 
University 

Shen, Fung- Win, Associate Professor of 
Immunobiology. B.S. 1968, Fu-Jen 
Catholic University (Taiwan); M.S. 1971, 
Ph.D. 1973, University of New Mexico 

Sherman, Merry R.. Associate Professor of Cell 
Biology and Genetics. B.A. 1961, 
Wcllesley College; M A. 1963, Ph.D. 
1966, University of California at Berkeley 

Silagi, Selma, Professor of Genetics in 

Obstetrics and Gynecology. A.B. 1936, 
Hunter College; Ph.D. 1961. Columbia 
University 

Silverstone, Allen E., Assistant Professor of Cell 
Biology and Genetics. B.A. 1964, Reed 
College; Ph.D. 1970, Massachusetts 
Institute of Technology 

Siniscalco, Marcello, Professor of Cell Biology 
and Genetics M.D. 1948, University of 
Naples (Italy) 

Sirlin. Julio L.. Professor of Cell Biology and 
Anatomy. D.Sc. 1953, University of 
Buenos Aires (Argentina) 



103 



Sirotnak, Francis M., Professor of Develop- 
mental Therapy and Clinical Investiga- 
tion. B.S. 1950, University of Scranton; 
Ph.D. 1954, University of Maryland 

Siskind, Gregory W., Professor of Medicine. 
B.A. 1955, Cornell University; M.D. 
1959, New York University 

Smith, Gerard P., Professor of Psychiatry 
(Behavioral Science). B.S. 1956, St. 
Joseph's College; M.D. 1960, University 
of Pennsylvania 

Soffer, Richard L., Professor of Biochemistry 
and Medicine. B.A. 1954, Amherst 
College; M.D. 1958, Harvard University 

Sonenberg, Martin, Professor of Cell Biology 
and Genetics. B.S. 1941, University of 
Pennsylvania; M.D. 1944, Ph.D. 1952, 
New York University 

Stavnezer, Edward, Assistant Professor of 

Molecular Biology and Virology. B.A. 

1965, M.S. 1967, University of 
Connecticut; Ph.D. 1971, Johns 
Hopkins University 

Stavnezer, Janet, Assistant Professor of 

Molecular Biology and Virology. B.A. 

1966, Swarthmore College; Ph.D. 1971, 
Johns Hopkins University 

Stenzel, Kurt H., Professor of Medicine; 

Professor of Biochemistry in Surgery. 
B.S. 1954, New York University; M.D. 
1958, Cornell University 

Stephenson, John L., Professor of Bio- 
mathematics in Physiology. B.A. 1943, 
Harvard University; M.D. 1949, 
University of Illinois 

Sternberg, Stephen S., Professor of Develop- 
mental Therapy and Clinical Investiga- 
tion. B.A. 1941, Colby College; M.D. 
1944, New York University 

Sterner, Richard, Adjunct Assistant Professor 
of Genetics. B.A. 1968, University of 
California at Berkeley; M.S. 1969, 
Ph.D. 1970, University of Chicago 

Stokes, Peter E., Associate Professor of Medicine 
and Psychiatry. B.S. 1958, Trinity 
College; M.D. 1952, Cornell University 

Stutman, Osias, Professor of Immunobiology. 
B.A. 1950, Colegio Nacional Sarmiento 
(Argentina); M.D. 1957, Buenos Aires 
University Medical School (Argentina) 



Sugg, John V., Emeritus Professor of Micro- 
biology. A.B. 1926, M.S. 1928, Ph.D. 
1931, Vanderbilt University 

Sussdorf, Dieter H ., Associate Professor of 

Microbiology. B.A. 1952, University of 
Missouri; Ph.D. 1956, University of 
Chicago 

Swan, Roy C , Joseph C. Hinsey Professor of 
Cell Biology and Anatomy. A.B. 1941, 
M.D. 1947, Cornell University 

Szeto, Hazel H., Associate Professor of Pharma- 
cology. B.S. l l )72, Indiana University; 
Ph.D., M.D. 1977, Cornell University 

Tate, Suresh S., Associate Professor of Bio- 
chemistry. B.Sc. 1958, M.SC. 1960, 
University of Baroda (India); Ph.D. 
1963, University of London (England) 

Teitelman, Gladys N., Assistant Professor of 
Neurobiology in Neurology. Licendiada 
in Biology 1962, University of Buenos 
Aires (Argentina); Ph.D. 1971, 
University of Pennsylvania 

Thaler, Howard T., Assistant Professor of 
Developmental Therapy and Clinical 
Investigation. B.A. 1967, University of 
California at Los Angeles; Ph.D. 1974, 
State University of New York at Buffalo 

Traktman, Paula, Assistant Professor of Cell 
Biology and Anatomy. A.B. 1974, 
Radcliffe College, Harvard University; 
Ph.D. 1981, Massachusetts Institute of 
Technology 

Tung, Jwu-Sheng, Assistant Professor of 

Immunobiology. B.A. 1959. National 
Taiwan University (Taiwan); M.S. 1966. 
Ph .D. 1971, University of California at 
Berkeley 

Udenfriend, Sidney, Adjunct Professor of Bio- 
chemistry. B.S. 1939, City College of 
New York; M.S. 1942, Ph.D. 1948, 
New York University 

Urban, Bernd W., Assistant Professor of 

Physiology and Biophysics. Diplom der 
Physik (Master) 1974, University of 
Karlsruhe (West Germany); Ph.D. 1978, 
University of Cambridge (England) 

Wall, Doris A., Assistant Professor of Cell 
Biology and Anatomy. B.A. 1970, 
University of New Hampshire; Ph.D. 
1975, Cornell University 



104 



Watanabc, Kyoichi A.. Professor of Develop- 
mental Therapy and Clinical Investiga- 
tion. Ph.D. 1963, Hokkaido University 
(japan) 

Wcinstcin , Alan M., Assistant Professor of 
Physiology and Biophysics. A.B. 1971, 
Princeton University; M.D. 1975, 
Harvard University 

Wckslcr, Babette B., Professor of Medicine. 
B.A. 1958, Swarthmorc College; M.D 
1963, Columbia University 

Wckslcr, Marc E., Irving Sherwood Wright 
Professor of Geriatrics; Professor of 
Medicine. B.A. 1958, Swarthmore 
College; M.D. 1962, Columbia University 

Wellner, Daniel, Associate Professor of Bio- 
chemistry. A.B. 1956, Harvard Univer- 
sity, Ph.D. 1961, Tufts University 

Wiebc, Michael E , Adjunct Associate Professor 
of Microbiology. B.A. 1965, Sterling 
College; Ph.D. 1971, University of 
Kansas 

Windhagcr, Erich E.. Maxwell M. Upson 

Professor of Physiology and Biophysics. 
M.D. 1954, University of Vienna 
(Austria) 

Wong, George Y., Assistant Professor of 
Developmental Therapy and Clinical 
Investigation. B.A. 1973, Rice 
University; M.A. 1975, Ph.D. 1978. 
Harvard University 

Woods, Kenneth R., Associate Professor of 

Biochemistry. B.A. 1948, Arizona State 
University; Ph.D. 1955, University of 
Minnesota 

Young. Robert C, Assistant Professor of 

Psychiatry in Neurobiology. B.A. 1969. 
Williams College; M.D. 1974, Cornell 
University 

Zakim, David. Vincent Astor Distinguished 
Professor of Medicine. B.A. 1956, 
Cornell University; M.D. 1961, State 
University of New York Downstate 
Medical Center 

Zcitz, Louis, Associate Professor of Develop- 
mental Therapy and Clinical Investiga- 
tion. A.B. 1948, University of 
California; Ph.D. 1962, Stanford 
University 



Degree Recipients 1983-84 

Doctors of Philosophy 

Anderson, Mary E., B.A. 1977, Hollins ( College. 
Major: Biochemistry. San Antonio, Texas 

Arnold, Angelo N., B.S. 1972, State University 
of New York at Stony Brook; M.S. 
1978, C.W. Post. Major: Biochemistry. 
Brooklyn, New York 

Beaton, Ann R., B.S. 1976, Cornell University. 
Major: Molecular Biology and Virology. 
Port Chester, New York 

Burns, Jacqueline P., B.S. 1978, Marymount 
Manhattan College. Major: Cell Biology 
and Genetics. New York, New York 

Chen, Chun-Chang, B.S. 1977, Taiwan 

University. Major: Biochemistry. Taipei, 
Taiwan 

Cheung, Margaret K., B.S. 1978, University 
of Michigan. Major: Immunobiology. 
Hong Kong 

Chorney, Michael J., B.S. 1975, M.S. 1977, 
Lehigh University. Major: Cell Biology 
and Genetics. Allcntown, Pennsylvania 

Devaney, Margaret, B.S., B.A. 1977, 

University of Pennsylvania. Major: 
Microbiology. Lancaster, Pennsylvania 

Fitzpatrick, Susan M., B.S. 1978, St. John's 
University. Major: Biochemistry. 
Brooklyn, New York 

Garrisi, Garland J., B.A. 1977, Colgate 

University; M.S. 1979, Boston College. 
Major: Cell Biology and Genetics. 
Detroit, Michigan 

Haspel, Howard C, B.S. 1978, Polytechnic 

Institute of New York. Major: Cell Biology 
and Genetics. Brooklyn, New York 

Ishizaka, Sally T., B.A. 1976, Wellesley 
College. Major: Immunobiology. 
Philadelphia, Pennsylvania 

Lcdcrman. Lynne, B.S. 1971, State University 
of New York at Stony Brook; M.S. 1974, 
Cornell University. Major: Molecular 
Biology and Virology. New York, 
New York 



105 



Lipkowitz, Stanley, B.A. 1977, Cornell 
University. Major: Biochemistry. 
Ferndale, New York 

Lockhart, Stephen Harold, A.B. 1977, 

Washington University; M. Phil. 1979, 
Oxford University (England). Major: 
Developmental Therapy and Clinical 
Investigation. St. Louis, Missouri 

Nakamura, Dean H., B.S. 1974, M.S. 1977, 

University of Hawaii. Major: Cell Biology 
and Genetics. Honolulu, Hawaii 

Nash, Barbara T., B.S. 1972, City University of 
New York; M.S. 1974, Yale University. 
Major: Biochemistry. Larchmont, 
New York 

Powell, Andrea M., B.A. 1978, Manhattanville 
College. Major: Pharmacology. 
New Rochelle, New York 

Rokovich, Joseph A., B.S. 1976, M.S. 1978, 
California State College. Major: 
Pathology. New Eagle, Pennsylvania 

Scotto, Kathleen V., B.S. 1977, St. John's 
University. Major: Molecular Biology 
and Virology. Queens, New York 

Storella, Robert J., B.A. 1978, Wesleyan 
University. Major: Pharmacology. 
Brighton, Massachusetts 

Stuckey, Jeffrey A., B.S. 1977, Butler 

University. Major: Neurobiology and 
Behavior. Lima, Ohio 

Todd, G. Peter, B.S. 1977, Utah State 
University. Major: Biochemistry. 
Washington, D.C. 



Masters of Science 

Mohamed, Anwar Noori, M.B., Ch.B. 1977, 
Mosul Medical College. Major: Cell 
Biology and Genetics. Mosul, Iraq 

Owen, Deborah G., B.S. 1974, University of 
Louisville. Major: Microbiology. 
Louisville, Kentucky 



Students 1984-85 

Candidates for the Degree of 
Doctor of Philosophy 

Abate, Corinne, B.A. 1983, Fordham Univer- 
sity. Major: Neurobiology and Behavior. 
Brooklyn, New York 

Acosta, Alberto M., B.A. 1978, Columbia 
University. Major: Pathology. Havana, 
Cuba 

Albert, Vivian Risa, B.A. 1979, M.S. 1980, 

Stanford University. Major: Neurobiology 
and Behavior. Los Angeles, California 

Arnold, James B., B.A. 1982, Columbia 
College. Major: Neurobiology and 
Behavior. New York, New York 

Askari, Frederick K., B.A. 1981, Cornell 
University. Major: Pharmacology. 
Toledo, Ohio 

Batter, David K., B.S. 1979, University of 
Connecticut. Major: Cell Biology and 
Genetics. New Haven, Connecticut 

Bauchwitz, Robert P., B.A. 1982, Harvard 
University. Major: Molecular Biology 
and Virology. Wilmington, Delaware 

Belkowski, Linda S., B.A. 1979, Rutgers 

University. Major: Molecular Biology 
and Virology. Perth Amboy, New Jersey 

Berger, Scott B., B.A. 1983, Emory University. 
Major: Neurobiology and Behavior. 
Pittsburgh, Pennsylvania 

Bergold, Peter J., B.S. 1977, Trinity College. 
Major: Molecular Biology and Virology. 
Teaneck, New Jersey 

Blank, Seymour G., B E E. 1965, City 

University of New York; M.E.E. 1968, 
New York University. Major: Physiology 
and Biophysics. Brooklyn, New York 

Braam-Markson, Janet, B.S. 1980, Southern 
Illinois. Major: Molecular Biology and 
Virology. Chicago, Illinois 

Brennan, Lynn A., B.A. 1974, Rutgers 

University. Major: Molecular Biology 
and Virology. New York, New York 



106 



Bridges, Richard J.. AS. 1975, Santa Rosa 

Junior College; B.S. 1977, University of 
California at Davis. Major Buxhemistry 
Santa Rosa, California 

Brock. Alice M.. A.B. 1978, Smith College; 
M.S.H.S. 1980, Northeastern University. 
Major: Cell Biology and Genetics, 
Scardsale, New York 

Brodeur, David. B.S. 1979. College of William 
and Mary . Major: Molecular Biology 
and Virology. Brooklyn, New York 

Buck, Charles R.. B.S. 1983, College of Idaho 
Major: Cell Biology and Genetics. 
Caldwell, Idaho 

Chan, Marion Man-Ying. B.S. 1975, M.S. 
1978, University of Maryland. Major: 
Immunohiology. Hong Kong 

Chaum. Edward, B A. 1979, Johns Hopkins 
University. Major: Cell Biology and 
Genetics. Los Angeles, California 

Chen. Yao-Tscng, B. Med. 1981, College of 
Medicine. National Taiwan University 
Major: Immunohiology. Tainan, Taiwan 

•Choy, Janet Wing, A.B. 1977. Smith College 
Major: Cell Biology and Genetics. 
Wayne. New Jersey 

Clurman. Bruce E., B.A. 1981. University of 
Virginia. Major: Molecular Biology and 
Virology. Cherry Hill, New Jersey 

Colacino, Joseph M., B.A. 1975, University of 
Connecticut; M.S. 1979, Southern 
Connecticut State College Major: 
Immunohiology New Haven, 
Connecticut 

Colmcnarcs, Clcmcncia, B.S. 1976, Yale 
University. Major: Immunohiology. 
Bogota, Colombia 

Conti, Peter S., B.A. 1978, Johns Hopkins 
University. Major: Developmental 
Therapy and Clinical Investigation. 
Yonkcrs, New York 

Cordon -Cardo. Carlos B , M.D. 1980, 

Autonomous University (Spain). Major: 
Cell Biology and Genetics. Calella, 
Spain 

'Cruz-Bracho, Maria R , Licenciada en 

Quimica 1978, Simon Bolivar University; 
M.Sc. 1981, Instituto Venezolano de 
Invcstigaciones Cientificas (Venezuela) 
Major: Cell Biology and Genetics. 
Caracas, Venezuela 



Davatelis, George N., B.A. 1977, Montclair 
State College; M.S. 1979, University of 
Hawaii. Major: Cell Biology and 
Genetics. Patcrson, New Jersey 

DiPaola, Eugene A , B.S 1974. Manhattan 
College. Major: Cell Biology and 
Genetics. Boston, Massachusetts 

DiSanto, James P., B.A. 1983. Johns Hopkins 
University Sloan-Kettering Division. 
Cherry Hill, New Jersey 

Dogramajian, Mary Ellen, B.S. 1977, M.S. 
1983, St. John's University. Major: 
Pharmacology. Huntington, New York 

Doucctte, Lynn Anne, B.Sc. 1981, McMastcr 
University (Canada). Major: Cell Biology 
and Genetics. Toronto, Canada 

Drozdoff, Vladimir V., B.A. 1979, Bowdoin 
College. Major: Developmental Therapy 
and Clinical Investigation. Cooper, 
Maine 

Eibl, Beatrice S., M.S. 1982, University of 
Vienna. Major: Cell Biology and 
Genetics. Vienna, Austria 

Einhebcr, Steven, B.S. 1981, George 

Washington University Major: Cell 
Biology and Genetics. Washington, D C. 

Fairfield, Alexandra. B.S. 1978, Cornell 
University. Major: Microbiology. 
Pittsburgh, Pennsylvania 

Fcbbraio, Maria, B.S. 1982, Fordham University. 
Major: Microbiology. Staten Island, 
New York 

Foxman, Brett, B.A. 1982, Boston University; 
M.D. 1982, Boston University School of 
Medicine. Major: Neurobiology and 
Behavior. Penn Valley. Pennsylvania 

Green, William Nathan, B.Sc. 1978, University 
of Toronto. Major: Physiology and 
Biophysics. Buffalo, New York 

Groden, Joanna L., B.A. 1978, Middlebury 
College. Major: Cell Biology and 
Genetics. Cambridge, Massachusetts 

Gulati, Poonam, B.A. 1982, Cornell University. 
Major: Microbiology. Collins, New York 

Gummere. Gregory R.. B.A. 1979, M.S. 1981, 
University of Cincinnati Major: Cell 
Biology and Genetics. Cincinnati, Ohio 

" Leave of absence 



107 



Hachfcld, Ughetta del Balzo, B.A. 1981, 

Barnard College. Major: Pharmacology. 
Rome, Italy 

Hariri, Robert, B.A. 1980, Columbia College. 
Major: Pathology. Forest Hills, New York 

Harris, Andrea, B.A. 1979, Boston University. 
Major: Microbiology. Hampton Bays, 
New York 

Harris, Paul E., A.B. 1978, University of 
California. Major: Cell Biology and 
Genetics. Philadelphia, Pennsylvania 

Heinrich, N.Julia, B.A. 1977, Brown 

University. Major: Molecular Biology 
and Virology. New York, New York 

Hinman, Lois M., B.S. 1969, Simmons College. 
Major: Biochemistry. New Haven, 
Connecticut 

"Hodes, Marquis Z., A.B. 1973, Indiana 

University at Bloomington; M.S. 1976, 
Indiana University at Indianapolis. 
Major: Immunobiology. Indianapolis, 
Indiana 

Hughes, MirandaJ., B.S. 1978, State Univer- 
sity of New York. Major: Pharmacology. 
Sydney, Australia 

Hume, Clifford R., B.A. 1983, Carleton 
College. Major: Immunobiology. 
Incline Village, Nevada 

Hwang, Onyou, A.B. 1982, Smith College. 
Major: Neurobiology and Behavior. 
Seoul, Korea 

Ippolito, Catherine L., B.S. 1982, State 

University of New York at Stony Brook. 
Major: Biochemistry. East Meadow, 
New York 

Jaudon, Carol E., B.S. 1981, Mississippi 
University for Women. Major: 
Molecular Biology and Virology. 
Arlington, Texas 

Jenkins, Deborah L., B.A. 1983, Williams 

College. Major: Biochemistry. Amherst, 
Massachusetts 

Jeong, Gajin, B.S. 1976, M.S. 1978, Seoul 

National University. Major: Cell Biology 
and Genetics. Daejeon, Korea 

Kanter, Madge R., B.A. 1982, University of 
California at Santa Cruz. Major: 
Molecular Biology and Virology. 
Palo Alto, California 



Kaseman, Deborah S., B.S. 1978, North Dakota 
State University. Major: Biochemistry. 
Ashley, North Dakota 

Kelly, Catherine D., B.A. 1981, State 

University of New York at Purchase. 
Major: Microbiology. Rockville Center, 
New York 

Kenny, Mark K., B.A. 1983, Wesleyan 

University. Major: Molecular Biology 
and Virology. Chappaqua, New York 

'Klein, Deborah, B.A. 1973, New York 
University; M.S. 1978, Fordham 
University. Major: Cell Biology and 
Genetics. Teaneck, New Jersey 

Klein, Renate F., B.A. 1977, New York 

University. Major: Pathology. Munich, 
West Germany 

Kornack, David R., B.S. 1983, Northern 

Illinois University. Major: Neurobiology 
and Behavior. Lombard, Illinois 

Lader, Eric Scott, B.S. 1981, Brooklyn College. 
Major: Cell Biology and Genetics. 
Brooklyn, New York 

Lee, William T.L., B.A. 1978, Johns Hopkins 
University. Major: Cell Biology and 
Genetics. Charlotte, North Carolina 

Le Strange, Renee C, B.A. 1978, University of 
North Carolina. Major: Immunobiology. 
Long Branch, New Jersey 

'Levene, Richard B., B.S. 1972, Tulane 

University; M.A. 1980, State University 
of New York. Major: Physiology and 
Biophysics. New York, New York 

Levine, Sulamita, M.D. 1975, M.S. 1980, 
University of Zulia Medical School 
(Venezuela). Major: Neurobiology and 
Behavior. Maracaibo, Venezuela 

Li, Luyuan, Graduate Certificate 1982, Sichuan 
University. Major: Biochemistry. Zunyi 
City, People's Republic of China 

'Louie, Elaine, B.S. 1974, Brooklyn College. 
Major: Cell Biology and Genetics. New 
York, New York 

Lufkin, Thomas C, A.B. 1981, University of 
California, Berkeley. Major: Molecular 
Biology and Virology. Birmingham, 
Michigan 



108 



Martinez, Humbcno Jose, M.D. 1975, 
University of Zulia Medical School 
(Venezuela). Major: Neurobiology and 
Behavior. Maracaibo, Venezuela 

Maurer, David H., A B. 1977, Cornell 

University. Major: Immunobiology. 
Newburgh, New York 

Michitsch, Richard W., B.A. 1975. M.S. 1978, 
New York University. Major: Molecular 
Biology and Virology. Brooklyn, 
New York 

Mok, Minsen, B.A. 1982. Johns Hopkins 
University. Major: Cell Biology and 
Genetics. Convent Station, New Jersey 

Montgomery, Kate T., B.A. 1978, Vassar 

College. Major: Molecular Biology and 
Virology. Chappaqua, New York 

"Musket, David Brian, B.A. 1980. Boston 
College. Major: Neurobiology and 
Behavior. Providence. Rhode Island 

Mynarcik, Dennis C, B.S. 1978, University 
of Texas at San Antonio. Major: Bio- 
chemistry. San Antonio, Texas 

•Nichols, Margaret E.. A.I.M.L.S. 1962, Sir 
John Cass College (England); F.I.M.L.S. 
1964, Mid Essex College (England). 
Major: Cell Biology and Genetics. 
England 

Nocka, Karl H., B.A. 1983, Bowdoin College 
Major: Molecular Biology and Virology. 
Ridgewood, New Jersey 

Pearse, Roger N., B.A. 1977, Dartmouth 
College. Major: Pathology. Newport, 
Rhode Island 

Peterson, Christine, B.S. 1976, Herbert H 

Lehman College; M A. 1978, University 
of California, Santa Barbara. Major: 
Neurobiology and Behavior. Bronx. 
New York 

•Potter. Virginia P., S.B. 1977, M.S. 1978. 
Massachusetts Institute of Technology . 
Major: Pharmacology. New York, 
New York 

Qiu. Feihua. M.D. 1979, Beijing Medical 
College Major: Cell Biology and 
Genetics Shanghai. People's Republic 
of China 



Reinach, Fernando dc C, B.S. 1978. M.S. 
1980, University of Sao Paulo, Brazil. 
Major: Cell Biology and Genetics. 
Brooklyn, New York 

Rico-Hesse, Rebecca, B.S. 1978, University of 
Nebraska; M.P.H. 1980, University of 
Minnesota Major: Microbiology. 
Los Angeles, California 

•Riley, RichardJ., B.S. 1972, Manhattan 

College; M.S. 1976, New York University. 
Major: Developmental Therapy and 
Clinical Investigation. Yonkcrs, New York 

Robertson, Donna A., B.S. 1979, Syracuse 
University. Major: Pharmacology. 
White Plains, New York 

Rosenberg. Charles D., A.B. 1978. Washington 
University; M.S. 1979, State University 
of New York at Buffalo. Major: Cell 
Biology and Genetics. Merrick, New York 

•Rosenberg, Elizabeth A., B.A. 1981 , Wesleyan 
University. Major: Biochemistry. New 
York, New York 

Roux, Linda M., S.B. 1978, Massachusetts 
Institute of Technology. Major: 
Immunobiology. Los Angeles, California 

Rubino. Heidi M.. B.S. 1980, Muhlenberg 
College. Major: Biochemistry. New 
York, New York 

Rubino, Stephen D., B.S. 1980, Muhlenberg 
College. Major: Microbiology, Harrison, 
New York 

Russell, David S., B.A. 1982, Oberlin College. 
Major: Molecular Biology and Virology. 
Chagrin Falls, Ohio 

'Sadlik.John R., B.S. 1973, St. John's 

University. Major: Immunobiology. 
New York, New York 

Sehgal, Amita, B.Sc. 1981, Delhi University 
(India); M.Sc. 1983, Jawaharial Nehru 
University School of Life Sciences 
(India); Major: Cell Biology and 
Genetics. New Delhi, India 

Shaffer. Rose Mary. B.S. 1980. Loyola College. 
Major: Microbiology. Baltimore, 
Maryland 

Shapiro, Geoffrey I., B.A. 1981, Columbia 
University. Major: Molecular Biology 
and Virology. Schenectady, New York 



109 



Signorelli, Kathy L., B.A. 1982, Wellcsley 

College. Major: Molecular Biology and 
Virology. Strongsville, Ohio 

'Sordillo, Emilia M., A.B. 1976, Harvard 

University; M.D. 1980, Cornell Univer- 
sity. Major: Immunobiology. New York, 
New York 

Spiegel, Mary K., B.S. 1978, Duke University. 
Major: Pharmacology. Knoxville, 
Tennessee 

Stinavage, Paul Stanley, A.A.S. 1977, State 
University of New York at Morrisville; 
B.S. 1981, Mary wood College. Major: 
Microbiology. Susquehanna, 
Pennsylvania 

Taylor, Colleen, B.S. 1980, Siena College. 

Major: Microbiology. Newark, New Jersey 

Teumer, Jeffrey K., B.A. 1979, Colgate 

University. Major: Molecular Biology 
and Virology. Sheboygan, Wisconsin 

Thormodsson, Finnbogi R., B.Sc. 1980, Uni- 
versity of Iceland. Major: Neurobiology 
and Behavior. Reykjavik, Iceland 

Till, Martha L., B.S. 1975, Colorado State 
University. Major: Microbiology. 
Chicago, Illinois 

Underwood, Mark, B.A. 1981, University of 
Vermont. Major: Neurobiology and 
Behavior. St. Albans, Vermont 

Verzosa, Purificacion O., B.S.M.T. 1969, 

Centro Escolar University; M.S. 1977, 
Fairleigh Dickinson University. Major: 
Microbiology. Monsey, New York 

Vigar, Diane C, B.S. 1976, M.S. 1981, 

Wagner College. Major: Microbiology. 
Staten Island, New York 

von Kreuter, Betsy F., B.S. 1982, University 
of Vermont. Major: Pathology. Darien, 
Connecticut 

Wallace, David, B.S 1966, City University of 
New York. Major: Microbiology. New 
York, New York 

Weisman, Steven M., B.S., B.A. 1981, 

Fairleigh Dickinson University. Major: 
Pharmacology. Kansas City, Missouri 

Wu, Kai-Yuan, B.A. 1983, New York 

University. Major: Molecular Biology 
and Virology. Shanghai, People's 
Republic of China 



Yan, Ning, Diploma 1980, Nanjing University. 
Major: Biochemistry. Nanjing, People's 
Republic of China 

Yang, Jung-Mou, M.B. 1979, National Defense 
Medical Center. Major: Physiology and 
Biophysics. Taipei, Taiwan, Republic of 
China 

Candidates for the Degree of 
Master of Science 

Dorato, Andrea L., B.Sc, 1982, McGill 

University. Major: Molecular Biology and 
Virology. Montreal, Quebec, Canada 

Gudewili, Ellen V., B.S. 1979, State Univer- 
sity of New York at Stony Brook. Major: 
Pathology. Babylon, New York 

Matyas, John R., A.B. 1978, Cornell Univer- 
sity. Major: Cell Biology and Genetics. 
Pittsburgh, Pennsylvania 

Mirenda, Carol A., B.A. 1979. Rutgers 

University. Major: Molecular Biology 
and Virology. Englewood, New Jersey 

Rubock, MelissaJ., B.A. 1982, University of 
Pennsylvania. Major: Molecular Biology 
and Virology. Levittown, New York 

Ruether, James E., B.A. 1981, University of 
Colorado. Major: Molecular Biology and 
Virology. Albany, New York 

"Weissman, Lauren C, B.S. 1982, State 

University of New York at Binghamton. 
Major: Biochemistry. Binghamton, 
New York 



Entering Students 

Ark, Belinda C, A.B. 1984, Cornell University. 
Major: Cell Biology and Genetics. 
San Francisco, California 

Brooks, David G., B.A. 1982, University of 
Colorado; M.S. 1984, Michigan State 
University. Major: Cell Biology and 
Genetics. Rochester, Michigan 

Condon, Thomas P., B.A. 1984, University of 
Virginia. Major: Immunobiology. 
Fort Lauderdale, Florida 



110 



Dicker, Adam P.. B A. 1984, Columbia 
University. Major: Cell Biology and 
Genetics. Great Neck, New York 

Evans. Elizabeth V , B.A. 1980, Bennington 
College. Major: Cell Biology and 
Genetics La Jolla, California 

Firpo, Meri T„ B.A. 1984, Carroll College 
Major: Cell Biology and Genetics. 
Helena, Montana 

Glascow, Michele A., B.S. 1984. Lebanon 

Valley College. Major: Immunobiology. 
Mill Hall, Pennsylvania 

Goldfarb, Valentina. Diploma in Biochemistry 
1969, Moscow State University 
(U S S R ). Major: Biochemistry. New 
York, New York 

Gundersen. Doris I.. B.A. 1977, Clark 

University. Major: Cell Biology and 
Genetics. West Babylon, New York 

Hanna, Paul. B.S. 1984, St. John's University. 
Major: Biochemistry Queens Village, 
New York 

Kiinzi. Myriam S , B.A. 1984, Wcllesley 
College. Major: Cell Biology and 
Genetics. Upper Malboro, Maryland 

Lee. Myung Soo. M.D. 1979, M.M.S. 1980 

Seoul National University (Korea). Major: 
Immunobiology. Dongdaemum-ku, 
Seoul, Korea 

Maher, Kevin J.. B.S. 1984, Manhattan 

College. Major: Pathology. Yonkers, 
New York 

Mandcll, James W., A.B. 1984, Cornell 

University. Major: Neurobiology and 
Behavior. Charlottesville, Virginia 

Moncneff, Patrice M., B.S. 1984, Boston 
College. Major: Cell Biology and 
Genetics Park Ridge, New Jersey 

Parada, Camilo A., B.S. 1978, Licence Biology 
(Master of Science) 1981, Catholic 
University of Valparaiso (Chile). Major: 
Molecular Biology and Virology. White 
Plains, New York 

Tantravahi, JogiRaju V., B.A. 1984, Columbia 
University. Major: Cell Biology and 
Genetics. Waltham, Massachusetts 



Walcwski, Jose L., B.S. 1980, Pennsylvania 
State University; M A. 1984, Boston 
University. Major: Pharmacology. 
Newton, Massachusetts 

Weisinger, Pearl E., B.A. 1982, Queens 

College of the City University of New 
York. Major: Cell Biology and Genetics. 
Forest Hills, New York 

Wong, Gwendolyn T., B.S. 1984, McMaster 
University (Canada). Major: Cell 
Biology and Genetics. Hamilton, 
Ontario, Canada 



111 



Index 



113 



Index 



Administration, Register, 95 
Admission, 57 
Applications, 57 
Application Fee, 57 
Awards and Prizes, 66 

Biochemistry, Field of, 9, 71 
Biophysics, see Physiology and 
Biophysics 

Cell Biology and Genetics, Field and 

Unit of, 14, 38, 73, 84 
Courses, see under individual 

Fields and Units 

Degree Recipients, Register, 105 
Degree Requirements, 59 
Developmental Therapy and Clinical 
Investigation, Unit of, 42, 86 

Examinations, 62 
Executive Committee, 3 

Faculty, Register, 95 

Research Activities, see under 
individual Fields and Units 
Faculty Advisory Committee, 3 
Faculty and Research Activities, 7 

Medical College Division, 9 

Sloan-Kettering Division, 38 
Fellowships and Scholarships, 66 
Fields and Units 

Biochemistry, 9, 71 

Cell Biology and Genetics, 14, 
38, 73, 84 

Developmental Therapy and 
Clinical Investigation, 42, 86 

Immunobiology, 46, 88 

Microbiology, 21, 75 

Molecular Biology and 
Virology, 50, 90 

Neurobiology and Behavior, 24, 77 

Pathology, 28, 79 



Pharmacology, 29, 80 

Physiology and Biophysics, 33, 82 
Financial Assistance, 65 
Foreign Language Requirements, 63 

also see under individual Fields 
and Units 

Genetics, 

see Cell Biology and Genetics 
see Molecular Biology and Virology 

Grades, 60 

Health Services, 67 
Housing, see Residence Halls 

Immunobiology, Unit of, 46, 88 
Immunology, see Immunobiology 

see Microbiology 
In Absentia, 62 

Leave of Absence, 62 

M.D.-Ph.D. Programs, 4, 68 
Medical Scientist Training Programs, 

see M.D.-Ph.D. Programs 
Microbiology, Field of, 21, 75 
Molecular Biology and Virology, 

Unit of, 50, 90 

Neurobiology and Behavior, 
Field of, 24, 77 

Pathology, Field of, 28, 79 
Part-time Graduate Study, 61 
Ph.D.-M.D. Program, 4, 69 
Pharmacology, Field of, 29, 80 
Physiology and Biophysics, 

Field of, 33, 82 
Prizes, see Awards and Prizes 
Provisional Candidacy, 58 

Register, 93 
Registration, 60 



115 



Research Activities, of Faculty, 

see Faculty and Research Activities 

Residence and Residence Units, 60 
Transfer of, 61 

Residence Halls, 68 

Requirements and Course Offerings, 55 
General, 57 

Medical College Division, 71 
Sloan-Kettering Division, 84 

Scholarships, 

see Fellowships and Scholarships 
Special Committee, 59 
Special Students, 58 
Students, Register, 106 
Summer Research, 62 



Thesis, 63 

Tuition and Fees, 64 

Virology, 

see Molecular Biology and Virology 
see Microbiology 



116